Subjectively impaired bed mobility in Parkinson disease affects sleep efficiency

Louter, Maartje; Sloun, Ruud J. G. van; Pevernagie, Dirk; Arends, Johan; Cluitmans, P.J.M.; Bloem, Bastiaan R.; Overeem, Sebastiaan

doi:10.1016/j.sleep.2013.03.010

Cited by 43 publications

(33 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the data cannot as yet be generalized, the results of axial nocturnal movements in our pilot study have identified several characteristics of the problems of rolling over among patients with PD, including less frequent turns, smaller turns, and slower turns when compared with matched spouses. These findings reinforce previous observations of nocturnal hypokinesia-mostly conducted in the form of questionnaires and interviewsshowing that impaired bed mobility exists and is likely to contribute to a wide range of nocturnal motor symptoms and NMSs in patients with PD, such as stiffness, rigidity, pain, breathing disorders, nocturia, or even insomnia [5,9,[18][19][35][36][37]. Moreover, a number of recent studies support the negative effects of nocturnal hypokinesia on the overall sleep quality, daytime symptoms, and quality of life of both patients as well as caregivers [5,7,[35][36][37].…”

Section: Discussionsupporting

confidence: 90%

Capturing nighttime symptoms in Parkinson disease: Technical development and experimental verification of inertial sensors for nocturnal hypokinesia

et al. 2016

View full text Add to dashboard Cite

Abstract-Although nocturnal hypokinesia represents one of the most common nocturnal disabilities in Parkinson disease (PD), it is often a neglected problem in daily clinical practice. We have developed a portable ambulatory motion recorder (the NIGHT-Recorder), which consists of 16-bit triaxial integrated microelectromechanical system inertial sensors that are specifically designed to measure movements, register the position of the body with respect to gravity, and provide information on rotations on the longitudinal axis while lying in bed. The signal processing uses the forward derivative method to identify rolling over and getting out of bed as primary indicators. The prototype was tested on six PD pairs to measure their movements for one night. Using predetermined definitions, 134 movements were captured consisting of rolling over 115 times and getting out of bed 19 times. Patients with PD rolled over significantly fewer times than their spouses (p = 0.03), and the position change was significantly smaller in patients with PD (p = 0.03). Patients with PD rolled over at a significantly slower speed (p = 0.03) and acceleration (p = 0.03) than their spouses. In contrast, patients with PD got out of bed significantly more often than their spouses (p = 0.02). It is technically feasible to develop an easy-to-use, portable, and accurate device that can assist physicians in the assessment of nocturnal movements of patients with PD.

show abstract

Section: Discussionsupporting

confidence: 90%

Capturing nighttime symptoms in Parkinson disease: Technical development and experimental verification of inertial sensors for nocturnal hypokinesia

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Motor symptoms such as bradykinesia, rigidity, and tremor occur frequently in PD patients with wearing off of dopaminergic medications at night. These symptoms impair bed mobility, interrupt sleep, and decrease sleep efficiency (24). Although dopaminergic medications can improve motor symptoms and therefore potentially improve sleep, they can also be associated with poor sleep quality, decreased REM sleep, and excessive daytime sleepiness, including unexpected sudden onset of sleep (sleep attacks) (25–27).…”

Section: Resultsmentioning

confidence: 99%

Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review

et al. 2018

View full text Add to dashboard Cite

Sleep-wake disturbances are common non-motor manifestations in Parkinson Disease (PD). Complex pathophysiological changes secondary to neurodegeneration in combination with motor symptoms and dopaminergic medications contribute to development of sleep-wake disturbances. The management of sleep complaints in PD is important as this symptom can affect daily activities and impair quality of life. Deep brain stimulation (DBS) is an effective adjunctive therapy for management of motor symptoms in PD. However, its effect on non-motor symptoms including sleep-wake disturbances is not widely understood. In this article, we reviewed studies assessing the effect of DBS at various therapeutic targets on sleep-wake disturbances. Of the studies examining the role of DBS in sleep-wake disturbances, the effect of subthalamic nucleus stimulation is most widely studied and has shown improvement in sleep quality, sleep efficiency, and sleep duration. Although, studies investigating changes in sleep with stimulation of thalamus, globus pallidus interna, and pedunculopontine nucleus are limited, they support the potential for modulation of sleep-wake centers with DBS at these sites. The mechanism by which DBS at different anatomical targets affects sleep-wake disturbances in PD is unclear and may involves multiple factors, including improved motor symptoms, medication adjustment, and direct modulation of sleep-wake centers.

show abstract

“…All of the latter may contribute to sleep-onset insomnia, and wearing off of dopaminergic medications overnight[111] may lead to or exacerbate sleep maintenance insomnia as well. Rigidity, bradykinesia, and other less well-defined causes also manifest with impaired bed mobility, which commonly presents subjectively with sleep-maintenance insomnia[188,189], and is associated with reduced sleep efficiency as assessed by polysomnography[188]. Given the significant contribution motor symptoms have on insomnia in PD, bedtime and overnight dopaminergic medication therapy may be required by many patients, which, while helpful for sleep in some patients, can have detrimental effects on sleep others (table 4).…”

Section: Insomniamentioning

confidence: 99%

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Chahine

Amara

Videnović

2017

Sleep Medicine Reviews

274

249

View full text Add to dashboard Cite

Sleep disorders are among the most common non-motor manifestations in Parkinson’s disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005-2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated features, evaluation measures, and management of these disorders. The influence on sleep of medications used in the treatment of motor and non-motor symptoms of PD is detailed. Additionally, we suggest areas in need of further research.

show abstract

Subjectively impaired bed mobility in Parkinson disease affects sleep efficiency

Cited by 43 publications

References 26 publications

Capturing nighttime symptoms in Parkinson disease: Technical development and experimental verification of inertial sensors for nocturnal hypokinesia

Capturing nighttime symptoms in Parkinson disease: Technical development and experimental verification of inertial sensors for nocturnal hypokinesia

Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Contact Info

Product

Resources

About