Sublethal Bioconcentration of Fenitrothion in the Blood and Brain of the European Eel

Sancho, E.; Ferrando, M.D.; Ten, Amparo; Lleó, C; Andreu-Moliner, E.

doi:10.1007/s001289900699

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…Observed behavioral changes/effects were typical of neurotoxin toxicity and our results are in agreement with the behavioral changes reported by Sancho et al (1998b) and Sarikaya et al (2004).…”

Section: Discussionsupporting

confidence: 95%

How Sublethal Fenitrothion is Toxic in Carp (Cyprinus carpioL.) Fingerlings

Sepici-Dinçel

Sarıkaya

Selvı

et al. 2007

Toxicology Mechanisms and Methods

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The purpose of this study was to evaluate the effects of fenitrothion, an organophosphothionate insecticide, on selected serum hematological and biochemical parameters of carp (Cyprinus carpio L.) fingerlings and investigate histopathological changes after acute dose of exposure. Among those, cortisol and glucose are evaluated as responses of early life stages of carp to acute stress and hematological blood parameters are evaluated to investigate the mechanism of toxicity via histopathological changes to the standard test organism. No significant histological findings were observed in carp tissues (gills, liver, kidneys, spleen, gonads, brain, muscle, and skin) exposed to a sublethal concentration of 10 mg/L fenitrothion and controls. Hematocrit and erythrocyte counts were decreased significantly by exposure to fenitrothion when compared to the control group (25.26% +/- 0.82%, 1455 +/- 90.3 [10(3)/muL] vs. 28.83% +/- 1.60%, 1865 +/- 74.5 [10(3)/muL], P < 0.05), respectively. Leucocyte and thrombocyte counts did not change. Increases in plasma cortisol levels were found in the experimental group compared to controls (34.2 +/- 1.9 vs. 18.0 +/- 2.2, P < 0.05) respectively, while glucose, chloride, sodium, potassium, phosphorous, and brain MDA and FOX levels did not show significant differences from those of control (P > 0.05). As a result, we can conclude that early life stages of fish are very susceptible to the adverse effects of toxicants.

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Section: Discussionsupporting

confidence: 95%

How Sublethal Fenitrothion is Toxic in Carp (Cyprinus carpioL.) Fingerlings

Sepici-Dinçel

Sarıkaya

Selvı

et al. 2007

Toxicology Mechanisms and Methods

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“…The behavioral changes that we recorded upon A. fasciatus exposure to azinphos-methyl were qualitatively similar to both those found in goldfish under the same toxicant (Ferrari et al 2004) and those seen in Corydoras paleatus and Anguilla anguilla upon exposure to fenitrothion (Sancho et al, 1998;Sarikaya et al, 2004), an OP widely used against insect pests and mites. Taken together, these changes are typical signs of behavioral impairment caused by inhibition of brain cholinesterases in teleosts (Sandahl et al, 2005).…”

Section: Behavioral Changes Mortality (Lc 50 ) and Micronuclei Test supporting

confidence: 77%

“…Another novel important finding of this study was the velocity at which A. fasciatus brain AChE is recovered after toxicant is withdrawn, i.e., reaching 80% of normal enzymatic activity in 10 days. This is noteworthy, since recovery of brain cholinesterase activities upon exposure to OP pesticides has been found to be protracted in most fish species, usually taking several weeks (Sancho, 1998;Ferrari et al, 2004Ferrari et al, , 2007Cong et al, 2008). Cyprinus carpio, the quickest in this matter reported to date, takes about 15 days (Dembelé et al, 1999).…”

Section: Sensitivity Concentration-response Relationship and Recovermentioning

confidence: 99%

Inhibition, Recovery and Field Responses of Astyanax fasciatus (Cuvier, 1819) Brain Cholinesterases Upon Exposure to Azinphos-methyl

Pistone¹,

Eguren

Rodrı́guez-Ithurralde

2024

Ecotoxicol. Environ. Contam.

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Pesticides used in agriculture are among the most important environmental pollutants. Organophosphate and carbamate insecticides, intensely used in deciduous fruit-trees, may be transported to aquatic ecosystems by runoff. Northwest rural Montevideo possesses zones of fruit-tree farms, where azinphos-methyl is currently the most used pesticide. Despite the well-known neurotoxic properties of this agrochemical, studies of its effects on aquatic organisms are scarce in Uruguay. The main goal of this study was to evaluate effects on brain cholinesterases and erythrocyte micronuclei in Astyanax fasciatus exposed to azinphos-methyl in laboratory and field conditions. Dose-response curves showed concentration-dependent brain cholinesterase inhibitions and a LC 50 (48-hour) of 2.31 mg L-1 for azinphos-methyl. Fishes exposed for 48 hours to toxicant and then transferred to clear water recovered 80% of brain cholinesterase activity in 10 days. Field study indicated that A. fasciatus from a watershed with low contamination showed a brain cholinesterase specific activity of 62.2±5.1 Units mg-1 protein (22ºC) 97.7 % of which was acetylcholinesterase. Specimens from a basin with intense fruticulture exhibited a spatial gradient, those collected downstream to the farms showed brain acetylcholinesterase activities 32% lower than fishes captured upstream. In conclusion, our data suggest that A. fasciatus is a suitable species for ecotoxicological biomonitoring.

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“…Some of these chemicals are inhibitors of cholinergic nerve responses and can lead to restless behaviour, erratic swimming and convulsions in eels (Sancho, Ferrando & Andreu ; Sancho et al . ). In many locations, rice culture (with intensive use of organophosphate chemicals) and glass eel captures occur together; therefore, this seemed a possibility as there were no signs of viral pathology in the brain tissues.…”

Section: Discussionmentioning

confidence: 97%

Co‐Infection with Pseudomonas anguilliseptica and Delftia acidovorans in the European eel, Anguilla anguilla (L.): a case history of an illegally trafficked protected species

Andrée

Rodgers

Furones

et al. 2013

Journal of Fish Diseases

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Inspections by customs agents at Barcelona airport discovered 420 kg of contraband glass eels prepared for shipment to Hong Kong. After confiscation of these animals by police, they were transported to holding facilities to be maintained until after a judicial hearing. Upon arrival, they were separated into two groups and held under ambient flow-through conditions in fresh water. During their captivity period, several peaks in mortality occurred and multiple bacterial strains were isolated from moribund animals. Sequencing of 16S rDNA was used to determine specific identity of the isolates. An initial isolation of Pseudomonas anguilliseptica was treated with oxytetracycline. A subsequent isolation of Delftia acidovorans proved resistant to oxytetracycline and was treated with gentamicin in combination with sulphadiazine-trimethoprim. Once the health condition of the animals was stabilized, they were partitioned into groups and subsequently released as part of a restocking effort for the species following the guidelines of Regulation (EC) 1100/2007 (Anon 2007). This represents the first record for both bacterial species in the host Anguilla anguilla in the Spanish Mediterranean.

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Sublethal Bioconcentration of Fenitrothion in the Blood and Brain of the European Eel

Cited by 9 publications

References 9 publications

How Sublethal Fenitrothion is Toxic in Carp (Cyprinus carpioL.) Fingerlings

How Sublethal Fenitrothion is Toxic in Carp (Cyprinus carpioL.) Fingerlings

Inhibition, Recovery and Field Responses of Astyanax fasciatus (Cuvier, 1819) Brain Cholinesterases Upon Exposure to Azinphos-methyl

Co‐Infection with Pseudomonas anguilliseptica and Delftia acidovorans in the European eel, Anguilla anguilla (L.): a case history of an illegally trafficked protected species

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