Sublethal concentration of emamectin benzoate inhibits the growth of gypsy moth by inducing digestive dysfunction and nutrient metabolism disorder

Xu, Zhe; Bai, Jianyang; Li, Lü; Liang, Liwei; Ma, Xiaoqian; Ma, Ling

doi:10.1002/ps.6432

Cited by 24 publications

(20 citation statements)

References 41 publications

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“…Due to its burst release and rapid degradation of EMB under natural sun light, EMB shows a short half-lives (0.37-0.64 days) in the crops [32,34]. However, the residues of EMB might lead to sublethal effects over space and time, including influencing the developmental time, weight, fecundity, longevity and physiological parameters without directly causing death [16,[22][23][24][25]35]. FAW is a highly destructive polyphagous invasive pest that causes substantial losses to agricultural production.…”

Section: Discussionmentioning

confidence: 99%

“…Sublethal concentration of EMB could significantly influence the growth and development of pest [16,22,24,37]. Sublethal concentration exposure (LC 30 ) of EMB could delay the immature stages (larva, protonymph, and deutonymph) of P. citri [35].…”

Section: Effect Of Emb On the Performance Of Faw Parental Generationmentioning

confidence: 99%

“…EMB sublethal concentrations (LC 5 and LC 15 ) increased the larval period and decreased the pre-pupal and pupal weight of S. littoralis [22]. Sublehal concentration (LC 30 ) of EMB exposure decreased the larval weight of L. dispar at 48 and 72 h [24]. Lethal dose (LD 10 ) of EMB also reduced the larval weight of S. littoralis at 24 h [25].…”

Section: Effect Of Emb On the Performance Of Faw Parental Generationmentioning

confidence: 99%

“…), and reduce their population parameters [22]. LC 30 of EMB decrease the pupal weight, longevity and fecundity of Tuta absoluta (Meyrick) [23], and inhibit the body weight of Lymantria dispar (L.) [24]. EMB is mainly stomach toxicity, which has a specific contact-killing effect.…”

Section: Introductionmentioning

confidence: 99%

“…EMB is mainly stomach toxicity, which has a specific contact-killing effect. These sublethal effects of EMB on pests might be by influencing gamma-amino butyric acid (GABA) content, midgut injury, digestive dysfunction and nutrient metabolism disorder [24,25]. However, there is no information on the sublethal effect of EMB on the performance of FAW.…”

Section: Introductionmentioning

confidence: 99%

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Sublethal Effects of Emamectin Benzoate on Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)

Liu

Tan

et al. 2022

Agriculture

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Fall armyworm (FAW), Spodoptera frugiperda (Lepidoptera: Noctuidae), is a highly invasive polyphagous pest that causes great economic losses to agricultural production. Emamectin benzoate (EMB) is one of the most popular biopesticides with high antipest, anti-parasitic and anti-nematode activities and low toxicity. The present study was conducted to determine the lethality of EMB to FAW for 24 h. Sublethal effects of EMB on FAW parental and offspring generations were also assessed. LC10, LC20 and LC50 EMB for 24 h on FAW third instar larvae were 0.0127 mg/L, 0.0589 mg/L, and 0.1062 mg/L, respectively. A low dose of sublethal concentrations of EMB could significantly influence the life cycle of FAW parental and offspring generations. Sublethal concentration (LC20) of EMB significantly prolonged the pupal period of male and increased the pupal weight of male but not of female, and significantly delayed the oviposition period and longevity of adult FAW. In the FAW offspring generation, sublethal concentrations significantly increased the mortality of offspring pupae and pre-adults, and reduced the development time of offspring larvae and pre-adult male and female. Sublethal concentrations (LC10 and LC20) of EMB significantly decreased the FAW oviposition period. However, only LC10 significantly reduced FAW F1 female fecundity. No significant difference was found in the intrinsic rates of natural increase (rm), finite rate of population increase (λ), and net reproductive rate (R0) of FAW offspring exposed to sublethal concentrations. This is the first study to determine the sublethal concentrations of EMB on the life table parameters of two FAW generations. These findings can provide important implications for the rational utilization of FAW insecticides.

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Section: Discussionmentioning

confidence: 99%

Section: Effect Of Emb On the Performance Of Faw Parental Generationmentioning

confidence: 99%

Section: Effect Of Emb On the Performance Of Faw Parental Generationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sublethal Effects of Emamectin Benzoate on Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)

Liu

Tan

et al. 2022

Agriculture

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Transcriptome analysis of emamectin benzoate caused midgut damage by inducing oxidative stress, energy metabolism disorder and apoptosis in gypsy moth (Lymantria dispar)

Bai

et al. 2022

Pest Management Science

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BACKGROUND Emamectin benzoate (EMB) is a semisynthetic bioinsecticide, which has been widely used in the control of forestry and agricultural pests. However, the mechanism of its toxic effects on the non‐neural tissues has been rarely reported. Here, we explored the mechanism of the midgut damage induced by EMB in gypsy moth (Lymantria dispar) in order to better understand the toxicological mechanism of EMB. RESULTS Our results confirmed that EMB caused damage to the midgut of gypsy moth by inducing apoptosis. Transcriptome showed that 1469, 650 and 950 genes were significantly differentially expressed in the midgut of gypsy moth after 24, 48 and 72 h of EMB exposure, and oxidative stress, energy metabolism disorder and apoptosis may be related to the toxic effects of EMB. The indicators related to oxidative stress, energy metabolism and apoptosis were further examined. The results showed that EMB could cause oxidative stress by increasing ROS level and inhibiting antioxidant enzymes (P < 0.05), such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), which in turn causes mitochondria injury. Subsequently, energy metabolism was inhibited by downregulating the activities and mRNA level of energy metabolism enzymes. Furthermore, the mitochondrial apoptosis pathway was activated, triggering apoptosis, and eventually causing midgut injury in gypsy moth. CONCLUSION Our results indicated that EMB caused damage to midgut by inducing oxidative stress, energy metabolism disorder and apoptosis in gypsy moth. Our findings shed new light on the toxicological mechanism of EMB on non‐neural tissues from oxidative stress, energy metabolism and apoptosis perspectives. © 2022 Society of Chemical Industry.

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Comparative phosphoproteomics analysis provides insights into the responses of Chilo suppressalis to sublethal chlorantraniliprole exposure

Meng

Guan

Zhang

et al. 2023

Pest Management Science

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BACKGROUND Sublethal exposure to insecticides causes changes in insect behaviors and physiologies including feeding, mobility, communication, hormone homeostasis, development and fecundity, however, the underlying molecular mechanisms were largely unclear. Our previous studies revealed that sublethal chlorantraniliprole exposure disturbed the hormone homeostasis, reduced the weight and longevity and prolonged the developmental duration of Chilo suppressalis. In the present study, the potential phosphorylation modification regulation mechanisms in C. suppressalis in response to sublethal chlorantraniliprole exposure were explored using comparative and quantitative phosphoproteomics. RESULTS A total of 2640 phosphopeptides belonging to 1144 phosphoproteins were identified, among which 446 phosphopeptides derived from 303 unique phosphoproteins were differentially phosphorylated between the chlorantraniliprole‐treated and control larvae. The phosphorylation levels of differentially phosphorylated phosphopeptides were further validated using parallel reaction monitoring (PRM). Functional classification and protein–protein interaction of the differentially phosphorylated proteins (DPPs) were analyzed. Generalized analysis of the DPPs and the differentially expressed genes (DEGs) identified in our previous study showed that sublethal chlorantraniliprole exposure significantly changed the transcription and phosphorylation levels of genes/proteins associated with carbohydrate and lipid metabolism, cytoskeleton, signal transduction, transcription, translation and post‐translational modification, leading to the dysfunctions of energy metabolism, transcription regulation, protein synthesis and modification, and signal transduction in C. suppressalis. Further analysis of the phosphorylation motifs in DPPs revealed that the MAPKs, CDKs, CaMK II, PKA, PKC and CK II protein kinases might be directly responsible for the phosphoproteomics response of C. suppressalis to chlorantraniliprole treatment. CONCLUSION Our results provide abundant phosphorylation information for characterizing the protein modification in insects, and also provide valuable insights into the molecular mechanisms of insect post‐translational modifications in response to sublethal insecticide exposure. © 2023 Society of Chemical Industry.

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Sublethal concentration of emamectin benzoate inhibits the growth of gypsy moth by inducing digestive dysfunction and nutrient metabolism disorder

Cited by 24 publications

References 41 publications

Sublethal Effects of Emamectin Benzoate on Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)

Sublethal Effects of Emamectin Benzoate on Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)

Transcriptome analysis of emamectin benzoate caused midgut damage by inducing oxidative stress, energy metabolism disorder and apoptosis in gypsy moth (Lymantria dispar)

Comparative phosphoproteomics analysis provides insights into the responses of Chilo suppressalis to sublethal chlorantraniliprole exposure

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