Sublethal cyfluthrin toxicity to carp (Cyprinus carpio L.) fingerlings: Biochemical, hematological, histopathological alterations

Sepici-Dinçel, Aylin; Benlı, A. Çağlan Karasu; Selvı, Mahmut; Sarıkaya, Rabia; Şahin, Duygu; Özkul, İbrahim Ayhan; Erkoç, Fıgen

doi:10.1016/j.ecoenv.2009.01.008

Cited by 107 publications

(45 citation statements)

References 42 publications

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“…The increase in blood glucose concentrations is known as a general secondary response to stress of fish to acute toxic effects and is considered as a reliable indicator of environmental stress (Sepici-Dinçel et al 2009). Increase in serum glucose levels in fish under stress was reported by Cicik and Engin (2005).…”

Section: Resultsmentioning

confidence: 99%

A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of Nile tilapia, Oreochromis niloticus

Fırat

Çoğun

Yüzereroğlu

et al. 2011

Fish Physiol Biochem

238

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The present study was designed to compare the responses in freshwater fish Oreochromis niloticus exposed to a synthetic pyrethroid, cypermethrin (CYP); an essential metal, copper (Cu); and a nonessential metal, lead (Pb). Fish were exposed to 0.05 μg/l CYP, 0.05 mg/l Cu, and 0.05 mg/l Pb for 4 and 21 days, and the alterations in serum enzyme activities, metabolite, and ion levels were determined. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities increased in response to CYP, Cu, and Pb exposures at both exposure periods. While elevations in alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) activities and in cholesterol level were observed in pesticide-exposed fish at 4 and 21 days, they increased in Cu- and Pb-exposed fish at 21 days. Although metal-exposed fish showed increases in cortisol and glucose levels at 4 days followed by a return to control levels at the end of the exposure period, their levels elevated in pesticide-exposed fish at both exposure periods. Total protein levels decreased in Pb- and pesticide-exposed fish at 21 days. Na+ and Cl− levels decreased in pesticide-exposed fish at both exposure periods and in Cu- and Pb-exposed fish at 21 days. The exposures of pesticide and metals caused an elevation in K+ level at the end of the exposure period. The present study showed that observed alterations in all serum biochemical parameters of fish-treated pesticide were higher than those in fish exposed to metals.

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Section: Resultsmentioning

confidence: 99%

A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of Nile tilapia, Oreochromis niloticus

Fırat

Çoğun

Yüzereroğlu

et al. 2011

Fish Physiol Biochem

238

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“…Channa punctatus exposed to alphamethrin also showed a decrease in the activity of CAT [32]. Other type II synthetic pyrethroids such as λ -cyhalothrin [33], cypermethrin [34, 35], cyfluthrin [36], deltamethrin [37, 38], fenvalerate [39], cypermethrin, and λ -cyhalothrin [40] also increased lipid peroxidation and/or reduced CAT activity in different species of freshwater fish. Dinu et al [41] observed that superoxide dismutase (SOD) and catalase (CAT) activities were reduced in the liver along with activation of glutathione peroxidase (GPX), glutathione transferase (GST), and glutathione reductase (GR), while an increase in CAT, GST, and GR was recorded in the intestine.…”

Section: Oxidative Stress Biomarkersmentioning

confidence: 99%

Biomarkers of Type II Synthetic Pyrethroid Pesticides in Freshwater Fish

Kaviraj

Gupta

2014

BioMed Research International

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Type II synthetic pyrethroids contain an alpha-cyano group which renders them more neurotoxic than their noncyano type I counterparts. A wide array of biomarkers have been employed to delineate the toxic responses of freshwater fish to various type II synthetic pyrethroids. These include hematological, enzymatic, cytological, genetic, omic and other types of biomarkers. This review puts together the applications of different biomarkers in freshwater fish species in response to the toxicity of the major type II pyrethroid pesticides and assesses their present status, while speculating on the possible future directions.

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“…Kamlaveni et al (2001) studied effects of different type II pyrethroids (deltamethrin, cypermethrin, fenvalerate, and fluvalinate) on the activities of succinate dehydrogenase (SDH) and glucose-6-phosphate dehydrogenase (G6PD) in Cyprinus cario var communis and found a significant inhibition in SDH activity with concomitant elevation in G6PD, indicating stress inducing capacity of pyrethroids. Sepici-Dinçel et al (2009) reported cyfluthrin to produce marked oxidative stress and significant decline in chloride levels along with simultaneous elevation in levels of sodium and phosphorus in Cyprinus carpio. Sub-lethal concentrations of deltamethrin (0.25À0.5 mg/l) for 10, 20, and 30 days were reported to produce histopathological changes in gills, liver, and gut of the mosquitofish Gambusia affinis (Cengiz and Unlu 2006).…”

Section: Introductionmentioning

confidence: 96%

λ-Cyhalothrin and cypermethrin induce stress in the freshwater muddy fish,Clarias batrachus

Kumar

Sharma

Pandey

2014

Toxicological & Environmental Chemistry

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Sublethal cyfluthrin toxicity to carp (Cyprinus carpio L.) fingerlings: Biochemical, hematological, histopathological alterations

Cited by 107 publications

References 42 publications

A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of Nile tilapia, Oreochromis niloticus

A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of Nile tilapia, Oreochromis niloticus

Biomarkers of Type II Synthetic Pyrethroid Pesticides in Freshwater Fish

λ-Cyhalothrin and cypermethrin induce stress in the freshwater muddy fish,Clarias batrachus

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