Sublethal exposure to pyriproxyfen does not impair the abilities of the backswimmer Buenoa amnigenus to prey upon Aedes aegypti larvae

Valbon, Wilson Rodrigues; Araújo, Sabrina H. C.; Nery, Ritanne S; Barbosa, Julianna Freires; Newland, Philip L.; Oliveira, Eugênio E.

doi:10.1007/s10646-022-02562-2

Cited by 1 publication

(1 citation statement)

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“…Even though the rutin ligand did not dock inside the AeagOBP1 interior binding site because of its larger surface area, this molecule presented the best affinity energy, as well as interaction with amino acids closer to the receptor’s cavity, such as Arg23 and Ile125. This suggests that the principal role of the mechanism of action of rutin is repellency activity, as described in other insects [ 64 , 65 , 66 ].…”

Section: Discussionmentioning

confidence: 79%

Methanolic Extracts of Chiococca alba in Aedes aegypti Biorational Management: Larvicidal and Repellent Potential, and Selectivity against Non-Target Organisms

Borges

Haddi

Valbon

et al. 2022

Plants

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The use of formulations containing botanical products for controlling insects that vector human and animal diseases has increased in recent years. Plant extracts seem to offer fewer risks to the environment and to human health without reducing the application strategy’s efficacy when compared to synthetic and conventional insecticides and repellents. Here, we evaluated the potential of extracts obtained from caninana, Chiococca alba (L.) Hitchc. (Rubiaceae), plants as a tool to be integrated into the management of Aedes aegypti, one of the principal vectors for the transmission of arborviruses in humans. We assessed the larvicidal and repellence performance against adult mosquitoes and evaluated the potential undesired effects of the extracts on non-target organisms. We assessed the susceptibility and predatory abilities of the nymphs of Belostoma anurum, a naturally occurring mosquito larva predator, and evaluated the C. alba extract’s cytotoxic effects in mammalian cell lines. Our chromatographic analysis revealed 18 compounds, including rutin, naringin, myricetin, morin, and quercetin. The methanolic extracts of C. alba showed larvicidal (LC50 = 82 (72–94) mg/mL) activity without killing or affecting the abilities of B. anurum to prey upon mosquito larvae. Our in silico predictions revealed the molecular interactions between rutin and the AeagOBP1 receptor to be one possible mechanism for the repellent potential recorded for formulations containing C. alba extracts. Low cytotoxicity against mammalian cell lines reinforces the selectivity of C. alba extracts. Collectively, our findings highlight the potential of C. alba and one of its constituents (rutin) as alternative tools to be integrated into the management of A. aegypti mosquitoes.

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Section: Discussionmentioning

confidence: 79%