2015
DOI: 10.1002/etc.3145
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Sublethal health effects in laboratory rodents from environmentally relevant exposures to oil sands contaminants

Abstract: Increasing activity of oil sands extraction and processing in northern Alberta is marked by ongoing controversy about the nature and extent of associated environmental impacts. Bitumen contains a mixture of toxic chemicals, including metals and residual polycyclic aromatic hydrocarbons (PAHs), whose release into the environment poses a distinct risk to the surrounding environment, plus wildlife and human health. In the present study, the authors evaluated several subclinical biomarkers of exposure and effect t… Show more

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Cited by 12 publications
(14 citation statements)
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“…The dominant species in both cases were NAP, C1/C2-NAP, C1/C2-FL, and C1-PHE. Furthermore, the larger deposition impact of alk-PAHs compared to PAHs and DBTs identified in this study is also consistent with the higher alk-PAH concentrations in wetlands and in wildlife including wood frogs, muskrats, minks, river otters, moose, and wolves. Alk-PAHs exposure has led to changes in the organ size indicative of developmental issues and reduction in antioxidant defenses potentially leading to increased oxidative stress in laboratory mice . Tree swallow nestlings exposed to PAHs and other air contaminants has resulted in increased EROD (ethoxyresorufin O-dealkylase) levels, which signifies increased detoxification activity .…”
Section: Resultsmentioning
confidence: 99%
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“…The dominant species in both cases were NAP, C1/C2-NAP, C1/C2-FL, and C1-PHE. Furthermore, the larger deposition impact of alk-PAHs compared to PAHs and DBTs identified in this study is also consistent with the higher alk-PAH concentrations in wetlands and in wildlife including wood frogs, muskrats, minks, river otters, moose, and wolves. Alk-PAHs exposure has led to changes in the organ size indicative of developmental issues and reduction in antioxidant defenses potentially leading to increased oxidative stress in laboratory mice . Tree swallow nestlings exposed to PAHs and other air contaminants has resulted in increased EROD (ethoxyresorufin O-dealkylase) levels, which signifies increased detoxification activity .…”
Section: Resultsmentioning
confidence: 99%
“…30−32 Alk-PAHs exposure has led to changes in the organ size indicative of developmental issues and reduction in antioxidant defenses potentially leading to increased oxidative stress in laboratory mice. 33 Tree swallow nestlings exposed to PAHs and other air contaminants has resulted in increased EROD (ethoxyresorufin O-dealkylase) levels, which signifies increased detoxification activity. 34 Most of the research into wildlife effects focused on the exposure to oil sands processed water (OSPW), which includes tailings ponds, other detention ponds, wetlands, and reclaimed ponds.…”
Section: Environmental Science and Technologymentioning
confidence: 99%
“…Our findings are different from others in which contaminant exposure has exhausted antioxidant resources in wildlife species. 39,42 Although the laboratory technique to determine rGSH:GSSG is challenging and the accuracy of results has been questioned, 53 we argue that precision in analyzing samples within one study, produces meaningful comparative results.…”
Section: Discussionmentioning
confidence: 98%
“…Total glutathione (tGSH) and oxidized glutathione (oxGSH) were measured in 2014 using the methods and reagents described for liver samples in Rodri ́guez-Estival et al; 39 thiobarbituric acid-reactive substances (TBARS) were measured using the same methods in both 2014 and 2015. Minor adjustments were made in 2015 to improve efficiency of the analysis of tGSH and oxGSH (see SI, p S4).…”
Section: Lipid Peroxidation and Gsh Redox Status In Livermentioning
confidence: 99%
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