Sublimate Intoxication of Rat: A Pilot Scheme of Mortality and Renal Damage According to the Amount of Sublimate

Abstract

A series of rats was given different doses of sublimate as a one-time subcutaneous injection. The greatest polyuric effect without retention of urea, morphological renal damage, or mortality was obtained with 4 mg sublimate per kg body weight. Given 10 mg sublimate per kg body weight or more, all rats were rendered oliguric or anuric with extensive necrosis of the cells of the proximal tubules of the kidneys. Most of these rats died during the experimental period of 5 days. Support is given to the theory that sublimate intoxication affects both the glomerular filtration rate and the tubular reabsorption rate. Polyuria may thus be attributable to a discrepency between these two functions. Oliguria and anuria seem to be caused by a severe impairment of the glomerular function. Scand J Urol Nephrol4Scand J Urol Nephrol Downloaded from informahealthcare.com by McMaster University on 12/26/14For personal use only. -1961. Studies on the excretion of mercury in the kidneys. Acta Path Microbiol Scand, Suppl. 144, 115-117. Bloom, W. & Fawcett, D. W. 1962. A textbook of histology, 8th ed., p. 25. Saunders, Philadelphia and London. Cafruny, E. J. 1963. Histochemical demonstration of mercury in renal cells. In Proceedings of the first international pharmacological meeting, vol. 5 , pp. 15-21. Pergamon press, Oxford, London, New York and Paris. Cohen, E. M., Groot, C. A. de & Weber, J. F. 1954. The influence of mersalyl on phosphate metabolism in kidney slices from intravenously injected rats. Acra Physiol Pharmacol Need 3, 512-521. -1955. Influence of mersalyl on phosphate metabolism in kidney slices of intramuscularly injected rats. Acta Physiol Pharmacol Need 4, 1-8. Conn, H. L., Jr, Anderson, W. & Arena, S. 1953. Gas diffusion technique for measurement of renal blood flow with special reference to the intact, anuric subject. J Appl Physiol 5, 683689. COM, H. L., Jr, Wilds, L. & Helwig, J. 1954. A study of the renal circulation, tubular function and morphology, and urinary volume and composition in dogs following mercury poisoning and transfusion of human blood. J Clin Invest 33, 132-141. Flanigan, W. J. & Oken, D. E. 1965. Renal micropuncture study of the development of anuria in the rat with mercury-induced acute renal failure. J Clin Znvest 44,, 449-451. Scand J Urol Nephrol4