Sublingual gland tumors: Clinical, pathologic, and therapeutic analysis of 13 patients treated in a single institution

Abstract

Tumors of the sublingual gland are rare and are usually malignant. Radical surgery and adjuvant radiotherapy seems to offer adequate local and regional control. Unlike distant failure, local recurrence and regional metastases are not common.

Malignant sublingual gland tumors: demographics, prognostic factors, and treatment outcomes

“…The accepted treatment protocol is a wide surgical resection, with adjuvant radiation therapy for clinically advanced disease, high-grade tumors, or inadequate surgical margins. 5,12,13 Although adjuvant radiotherapy has been shown to improve locoregional control, controversy still remains as to its benefit with regards to overall or disease-free survival. 13,14 Much of the current existing literature for sublingual gland tumors consists of case reports and single institution studies, with large population data being limited to studies analyzing salivary gland tumors in general, rather than sublingual gland tumors specifically.…”

“…5,12,13 Although adjuvant radiotherapy has been shown to improve locoregional control, controversy still remains as to its benefit with regards to overall or disease-free survival. 13,14 Much of the current existing literature for sublingual gland tumors consists of case reports and single institution studies, with large population data being limited to studies analyzing salivary gland tumors in general, rather than sublingual gland tumors specifically. [1][2][3][4][5][6]10, The limited literature available presents challenges to understanding treatment, outcomes, and prognostic factors for sublingual gland tumors.…”

Pleomorphic Adenoma of the Sublingual Salivary Gland: An Unusual Diagnostic Challenge

“…The great majority of these tumors are malignant and few benign cases of pleomorphic adenomas, myoepitheliomas and oncocytomas have been described [7,8,9]. Sublingual benign tumors present as asymptomatic swelling of the floor of the mouth under the tongue, causing discomfort and difficulty in dental prosthesis retention [10], and may be incidentally discovered by a dentist, as happened in our case.…”

“…Sublingual salivary gland tumors are rare compared with other major glands with a reported ratio of 1 case of sublingual tumor to 100 parotid tumors [1] or less [7]. The great majority of these tumors are malignant and few benign cases of pleomorphic adenomas, myoepitheliomas and oncocytomas have been described [7,8,9].…”

Survival and mortality from oral cancer by anatomical location. A narrative review.

“…Pohad et al 34 found a median overall survival of 59 months for malignant tumors of the submandibular gland, the survival rate at 5 years was 50% and 28% at 10 years. In sublingual gland tumors, Zdanowski et al 35 reported an overall survival rate of 78.7% at 5 years and a rate of disease-free survival of 87.5%. Luksic et al 36 revealed a survival rate of 62%, 53%…”