Sublingual immunization induces broad-based systemic and mucosal immune responses in mice

Çuburu, Nicolas; Kweon, Mi‐Na; Song, Joo‐Hye; Hervouet, Catherine; Luci, Carmelo; Sun, Jiabin; Hofman, Paul; Holmgren, Jan; Anjuère, Fabienne; Czerkinsky, Cécil

doi:10.1016/j.vaccine.2007.09.073

Cited by 188 publications

(182 citation statements)

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“…We recently showed that the s.l. epithelium harbors a dense lattice of DCs and that CT adjuvant mobilizes DCs within the sublingual epithelium (8). These cells migrate to the proximal draining lymph node (e.g., submaxillary, superficial cervical, and internal jugular), which represent specialized microenvironments favoring the induction of mucosal tolerance (8).…”

Section: Discussionmentioning

confidence: 99%

“…epithelium harbors a dense lattice of DCs and that CT adjuvant mobilizes DCs within the sublingual epithelium (8). These cells migrate to the proximal draining lymph node (e.g., submaxillary, superficial cervical, and internal jugular), which represent specialized microenvironments favoring the induction of mucosal tolerance (8). Immune responses in mucosal tissues are determined by the route of delivery, by the nature of the Ag, by the type of Ag-presenting cells (APCs), and by the local microenvironment (2,5).…”

Section: Discussionmentioning

confidence: 99%

“…We have reported that s.l. administration of a prototype soluble protein together with a mucosal adjuvant induce a broad range of immune responses in mucosal and extramucosal tissues, including secretory and systemic antibody responses and mucosal and systemic cytotoxic T lymphocyte (CTL) responses (8).…”

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confidence: 99%

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Sublingual vaccination with influenza virus protects mice against lethal viral infection

Song

Nguyen

Çuburu

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sublingual vaccination with influenza virus protects mice against lethal viral infection

Song

Nguyen

Çuburu

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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188

147

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“…The SL route was recently adopted as a mode of vaccine delivery capable of eliciting both systemic and mucosal immune responses while avoiding many of the adverse effects and formulation difficulties associated with oral or IN vaccination. 29 In our previous study for the FlaB-adjuvanted NoV Pd vaccine, we had tried both IN and SL routes for immunization. 20 FlaB-mediated TLR5 signaling was responsible for the enhanced immune responses in both system and mucosal compartments.…”

Section: Discussionmentioning

confidence: 99%

More robust gut immune responses induced by combining intranasal and sublingual routes for prime-boost immunization

Hwang

Puth

Tan

et al. 2018

Human Vaccines & Immunotherapeutics

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Norovirus causes acute and debilitating gastroenteritis, characterized by vomiting and diarrhea. We recently reported a recombinant GII. 4 P domain particle (Pd) vaccine adjuvanted with a flagellin, Vibrio vulnificus FlaB, effectively promoting both humoral and cell-mediated immune responses. In the previous study, we found that sublingual (SL) immunization induced higher fecal secretory IgA (SIgA) responses while intranasal (IN) route provided higher amplitude of humoral and cellular immune responses in the systemic compartment. We hypothesized that the combination of IN and SL routes should induce more potent and sustained SIgA responses in the gut. In this study, we have tried combinatorial prime-boost immunization employing both IN and SL routes. The IN priming and SL boosting with the Pd+FlaB vaccine enhanced highest SIgA responses in feces, accompanying increased Pd-specific memory B cells and plasma cells in spleen and bone marrow, respectively. Notably, the strongest long-lasting SIgA response in feces was induced by combined IN prime and SL boost vaccination, which was sustained for more than 3 months. Significantly enhanced gut-homing B cell and follicular helper T cell responses in mesenteric lymph nodes (mLNs) were observed in the IN prime and SL boost combination. IN priming was a requisite for the robust induction of Pd-specific IFNγ, IL-2, IL-4 and IL-5 cytokine responses in the systemic immune compartment. Collectively, the IN prime and SL boost combination was the best option for inducing balanced long-lasting immune responses against the norovirus antigen in both enteric and systemic compartments. These results suggest that immune responses in specific mucosal compartments may be programmed by employing different prime-boost immunization routes.

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“…A maioria das vacinas utilizadas comercialmente é injetável, tendo como princípio básico conferir uma proteção, induzindo a produção de anticorpos séricos, ao invés de estimular uma resposta imune de mucosa (ÇUBURU et al, 2007).…”

Section: Imunização Em Filhotesunclassified

Resposta imune ao parvovírus canino tipo 2 (CPV 2) em hidrogel de quitosana administrado via sublingual

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Sublingual immunization induces broad-based systemic and mucosal immune responses in mice

Cited by 188 publications

References 50 publications

Sublingual vaccination with influenza virus protects mice against lethal viral infection

Sublingual vaccination with influenza virus protects mice against lethal viral infection

More robust gut immune responses induced by combining intranasal and sublingual routes for prime-boost immunization

Resposta imune ao parvovírus canino tipo 2 (CPV 2) em hidrogel de quitosana administrado via sublingual

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