2018
DOI: 10.1182/blood-2018-99-115393
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Sublingual Microcirculatory Imaging As a Novel Tool to Monitor for Cytokine Release Syndrome after Chimeric Antigen Receptor T-Cell Therapy

Abstract: Background: Chimeric antigen receptor T-cell (CAR-T) therapy is an FDA-approved therapy for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL). A common side effect of CAR-T therapy is cytokine release syndrome (CRS), and its severity ranges from mild to severe, and occasionally resulting in death. Patients at particularly high risk for severe CRS may benefit from earlier supportive care and rescue therapies, such as tocilizumab. Although the medi… Show more

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“…In a retrospective single-center study, fever occurred in 71% of patients within 72 h of axi-cel infusion, and it recurred in 69% of them after tocilizumab use (within 24 h in one-third of the cases) ( 28 ). As a result, more sensitive and specific tools for the early detection of CRS, including sublingual microcirculatory imaging, are currently under investigation ( 29 ).…”
Section: Axi-cel For Aggressive B-cell Lymphomamentioning
confidence: 99%
“…In a retrospective single-center study, fever occurred in 71% of patients within 72 h of axi-cel infusion, and it recurred in 69% of them after tocilizumab use (within 24 h in one-third of the cases) ( 28 ). As a result, more sensitive and specific tools for the early detection of CRS, including sublingual microcirculatory imaging, are currently under investigation ( 29 ).…”
Section: Axi-cel For Aggressive B-cell Lymphomamentioning
confidence: 99%