Sublingual tablets: an overview

Sah, Somya; Badola, Ashutosh; Kothiyal, Preeti

doi:10.30750/ijpbr.4.2.3

Cited by 10 publications

(9 citation statements)

References 7 publications

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“…Disintegration time is a major consideration for sublingual tablet. According to USP the disintegration time for subligual tablet is less than 2 minute is acceptable [20]. Reduction in the disintegration time is a added advantage of formulation for maximum absorption and compliance by the patient.…”

Section: Formulation and Evaluation Of Sublingual Tablet Of Lansoprazmentioning

confidence: 99%

Formulation and evaluation of lansoprazole sublingual tablet

Shelke¹,

Mutha²

2020

jrp

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The objectives of present investigation is to improve the solubility and rate of dissolution of poorly aqueous soluble drug lansoprazole by preparing solid dispersion with amphiphilic carrier Soluplus in 1:2 concentration by using solvent evaporation method, solvent melting method and microwave oven method and selecting the best solid dispersion. The drug and excipient compatibility study of selected solid dispersion was performed by FTIR and DSC. These study showed no interaction in drug and carrier. The sublingual tablet represents an innovative drug delivery system, sublingual tablet of lansoprazole was formulated by incorporating selected solid dispersion with combination of novel superdisintegrants and taste maskers like Indion-414 and Kyron T-314 by using direct compression method. The sublingual tablet showed the rapid disintegration within average 32 seconds. All the evaluations were performed and complies with the pharmacopoeial standards. The drug and excipient compatibility study of lansoprazole sublingual tablet was also performed by FTIR and DSC. These study showed no interaction in drug and excipients. The formulation F9 (12 % superdisintegrants) showed 98.42% of cumulative drug release within 8 min with zero order release pattern. These novel formulation lansoprazole sublingual tablet showed quick on set of action and may be found to be beneficial, convenient for pediatrics, geriatrics, and psychiatric patients and patients with swallowing difficulties and in situations where water is not available.

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Section: Formulation and Evaluation Of Sublingual Tablet Of Lansoprazmentioning

confidence: 99%

Formulation and evaluation of lansoprazole sublingual tablet

Shelke¹,

Mutha²

2020

jrp

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“…Acidic stimulation of the salivary glands, as well as the vasodilation, facilitates drug absorption in the systemic circulation. The buccal mucosal tissues and sublingual mucosal tissues are similar in their structure (Boer et al, 1984;Sah et al, 2016).…”

Section: Cellular Mechanism Of Drug Absorptionmentioning

confidence: 99%

Sublingual spray: a new technology oriented formulation with multiple benefits

Aravindhanthan

Anjali

Radhakrishnan

2019

ijrps

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Sublingual drug delivery system was a well-established platform for delivering the drug that need to exhibit quick action without any first-pass metabolic effect, but various pitfall in the regular sublingual drug delivery systems such as a tablet, capsule etc., that can be overcome by novel sublingual drug delivery technology such as particulate sublingual spray. Sublingual spray for drug administration has gained attention in the market since it proved its propensity to by-pass the first-pass metabolism and to initiate a rapid onset of action due to its atomized micro particulate nature, which is significantly higher than the other sublingual formulations. The approval of sublingual spray by the regulatory agencies may commence further research in this field by subsuming various essential drugs for indications such as cancer pain, cardiovascular issue etc. This article comprises a detailed study on the drawback of conventional sublingual drug delivery system and the approach by which these drawbacks can be overruled by spray technology in the sublingual area and the, in-depth mechanism of drug delivery through sublingual with the help of atomization followed by the entire formulation strategy along with evaluation and industrial perspective of the sublingual spray dosage form as a future tool of patient-friendly drug delivery.

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“…3 The drug is rapidly absorbed into the reticulated vein that is present underneath the oral mucosa, and transported it through the facial veins, internal jugular vein, braciocephalic vein and then unload in to systemic circulation. 4 Passive diffusion is the primary mechanism for the absorption of the drug in to oral Mucosa is via lipoidal membrane. The absorption of the drug via sublingual route is 3 to 10 times greater than oral route.…”

Section: International Journal Of Pharma Research and Health Sciencesmentioning

confidence: 99%

“…A secretion from the glands mix with food and help in chewing and making the food slippery so that it can be easily swallowed. 4 Low production of saliva can make the process of swallowing much more difficult and lodge the food content in the throat. 5 The absorption of the drug in the oral cavity is Sublingual > Buccal > Gingival >Palatal.…”

Section: International Journal Of Pharma Research and Health Sciencesmentioning

confidence: 99%

Sublingual Route: An Approach to Administered Drugs in Systemic Circulation

Moteriya¹,

Rana²,

Saroha³

et al. 2019

Int J Pharma Res Health Sci

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Due to ease of administration, versatility, painless and paramount patient compliance oral administration is considered as most satisfactory route for the administration of drug. For drug absorption in oral cavity, sublingual area is most permeable to drugs. The sublingual route bypasses the hepatic first-pass metabolism, which assist greater bioavailability with better patient compliance. Sublingual route is the most suitable now a days because people need effective relief within a short period. These tablets have the advantage of rapid disintegration and dissolution in saliva. For the instant drug delivery to paediatric and geriatric patients fast disintegrating sublingual tablets have shown significant improvements for specific patient group. This review enlightens the mechanism of sublingual absorption, physicochemical properties of a few sublingually administered drugs, factors affecting sublingual absorption, advantages, and evaluation parameters.

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Sublingual tablets: an overview

Cited by 10 publications

References 7 publications

Formulation and evaluation of lansoprazole sublingual tablet

Formulation and evaluation of lansoprazole sublingual tablet

Sublingual spray: a new technology oriented formulation with multiple benefits

Sublingual Route: An Approach to Administered Drugs in Systemic Circulation

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