Sublingual therapy for cobalamin deficiency as an alternative to oral and parenteral cobalamin supplementation

Delpre, G; Stark, Pinhas; Niv, Yaron

doi:10.1016/s0140-6736(99)02479-4

Cited by 42 publications

(32 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the increase in cobalamin concentrations was achieved by the end of the first week of treatment (Figure 1). Previous studies used sublingual or oral doses of 1000-5000 mg [5][6][7][8][9]. Our study shows that as little as 500 mg is enough to correct cobalamin deficiency.…”

Section: Discussionmentioning

confidence: 56%

Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route

Sharabi

Cohen

Sulkes

et al. 2003

Brit J Clinical Pharma

View full text Add to dashboard Cite

Aims To compare the efficacy of sublingual and oral administration of 500 m g of cobalamin in subjects with cobalamin deficiency. Materials and results Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to receive one tablet daily of 500 m g cobalamin sublingually or orally, or two tablets daily of a vitamin B complex. Serum cobalamin concentrations before treatment were 94 ± 30 pmol l -1 , 108 ± 17 pmol l -1 and 98 ± 14 pmol l -1 in the sublingual B12, oral B12 and oral B-complex groups, respectively. After 4 weeks, concentrations rose to 288 ± 74 pmol l -1 , 286 ± 87 pmol l -1 and 293 ± 78 pmol l -1 , respectively. The increase in each group across time was statistically significant ( P = 0.0001, differences [95% confidence intervals] 194. 2 (114.5, 273.9), 178.3 (104.2, 252.4), and 195.1 (135.0, 255.2) pmol l -1 , respectively). There was no significant difference in concentrations between the treatment groups. Conclusion A dose of 500 m g of cobalamin given either sublingually or orally is effective in correcting cobalamin deficiency.

show abstract

Section: Discussionmentioning

confidence: 56%

Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route

Sharabi

Cohen

Sulkes

et al. 2003

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…Another two articles were identified from hand search of bibliographic references of the shortlisted articles. A total of 12 articles [2 randomized controlled trials (RCTs) (10, 11), 3 prospective studies (12–14), 1 systematic review (15), and 6 clinical reviews (2, 16–20)] were obtained for the review.…”

Section: Resultsmentioning

confidence: 99%

“…The age range of the study population was 23–92 years old. The RCT by Kuzminski et al (10) and prospective study by Delpre et al (12) were done in America. The RCT by Bolaman et al (11) was done in Turkey.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Oral Vitamin B12 Replacement for the Treatment of Pernicious Anemia

2016

View full text Add to dashboard Cite

Many patients with pernicious anemia are treated with lifelong intramuscular (IM) vitamin B12 replacement. As early as the 1950s, there were studies suggesting that oral vitamin B12 replacement may provide adequate absorption. Nevertheless, oral vitamin B12 replacement in patients with pernicious anemia remains uncommon in clinical practice. The objective of this review is to provide an update on the effectiveness of oral vitamin B12 for the treatment of pernicious anemia, the recommended dosage, and the required frequency of laboratory test and clinical monitoring. Relevant articles were identified by PubMed search from January 1, 1980 to March 31, 2016 and through hand search of relevant reference articles. Two randomized controlled trials, three prospective papers, one systematic review, and three clinical reviews fulfilled our inclusion criteria. We found that oral vitamin B12 replacement at 1000 μg daily was adequate to replace vitamin B12 levels in patients with pernicious anemia. We conclude that oral vitamin B12 is an effective alternative to vitamin B12 IM injections. Patients should be offered this alternative after an informed discussion on the advantages and disadvantages of both treatment options.

show abstract

“…Oral therapy also may not be appropriate for those with swallowing difficulties; for such patients, sublingual B 12 therapy, which has been shown to be equally effective, may more appropriate [23]. …”

Section: Discussionmentioning

confidence: 99%

Oral vitamin B12therapy in the primary care setting: a qualitative and quantitative study of patient perspectives

et al. 2005

View full text Add to dashboard Cite

show abstract

Sublingual therapy for cobalamin deficiency as an alternative to oral and parenteral cobalamin supplementation

Cited by 42 publications

References 4 publications

Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route

Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route

Oral Vitamin B12 Replacement for the Treatment of Pernicious Anemia

Oral vitamin B12therapy in the primary care setting: a qualitative and quantitative study of patient perspectives

Contact Info

Product

Resources

About