Sublingual triazolam versus peroral diazepam as a premedication for general anaesthesia

Abstract

Sublingual triazolam 0.2 mg (T) was. compared with perorai diazepam 10 mg (D) as a premedicant in a randomisedAccepted for publication 9th June, 1995. There are many possible reasons for administering premedication, but the main one is to relieve fear and anxiety. 1-3 Other possible reasons are sedation, amnesia, analgesia, parasympatholytic, effect and decrease of salivation. From the patient's point of view, what matters is safety and that they experience as pleasant a visit to the operation unit as possible. It is well known that the preoperative visit of an anaesthetist has a calming effect. I; Benzodiazepines are the most popular premedicants for pharmacological sedation and anxiolysis because of their minimal side effects.~ Of the newer CAN J ANAESTH 1995 / 42:10 / pp 862-8

Characterization of captopril sublingual permeation: Determination of preferred routes and mechanisms

“…This route enjoys the advantages that it allows facile access, there is a potential for a quick onset of activity, there is usually improved bioavailability, and it offers the possibility of circumvention of the hepatic first‐pass elimination that decreases blood concentrations of perorally administered drugs. Examples of pharmacologically active compounds that may benefit from sublingual administration include nitrates (nitroglycerin) for angina pectoris,1 angiotensin‐converting enzyme inhibitors (captopril) for hypertensive crises,2 antihistamines (cetirizine) for allergic reactions,3 opioids (morphine) for analgesia,4 and benzodiazepines (triazolam) as hypnotics 5. In general, the sublingual route of drug delivery enjoys great potential for the administration of emergency medications.…”