1990
DOI: 10.1001/archotol.1990.01870090071011
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Submandibular Gland Tumors: Adverse Histologic Factors and Therapeutic Implications

Abstract: We reviewed our 41-year experience with tumors of the submandibular gland to determine what factors influence outcome and their implications for treatment. The most common benign neoplasm was pleomorphic adenoma (21), while among malignant tumors the adenoid cystic variety (37) predominated. For the 86 patients who had malignant tumors, the 2- and 5-year survivals by the life table method were 82% and 69%, respectively. For patients with malignant tumors, histology, size, perineural invasion, and prior treatme… Show more

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Cited by 117 publications
(70 citation statements)
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“…It was found in the oral cavity in 41%, the submandibular gland in 39%, and elsewhere in the head and neck region in 57%; in the parotid gland, however, it was found in 15%, which is in accordance with findings based on other series. 12,28,29 The risk of initial positive neck nodes was only 6% in our analysis and around 10% in the published data. 27,30,38 In light of the low risk, elective neck dissection is seldom required.…”
Section: Discussioncontrasting
confidence: 70%
“…It was found in the oral cavity in 41%, the submandibular gland in 39%, and elsewhere in the head and neck region in 57%; in the parotid gland, however, it was found in 15%, which is in accordance with findings based on other series. 12,28,29 The risk of initial positive neck nodes was only 6% in our analysis and around 10% in the published data. 27,30,38 In light of the low risk, elective neck dissection is seldom required.…”
Section: Discussioncontrasting
confidence: 70%
“…The majority of salivary gland tumors arise in the parotid gland, whereas only 5-15% occur in the submandibular gland [1][2][3][4]; however, submandibular gland neoplasms have a higher proportion of malignancy than parotid tumors [5]. Moreover, although uncommon, submandibular gland carcinomas demonstrate various histopathological subtypes and biological behaviors.…”
Section: Introductionmentioning
confidence: 99%
“…Retrospective data indicate a potential benefit for adjuvant radiation therapy (RT) in patients with malignant major salivary gland tumors (MMSGT) who have high-risk features (such as high grade, advanced stage, positive surgical margins, perineural/lymphovascular invasion, or recurrent tumors). While a number of retrospective studies suggest improved local control with adjuvant RT, [5][6][7][8][9][10][11][12][13][14][15][16] few have identified a significant survival benefit. [17][18][19][20] Given the variable inclusion criteria of these retrospective series, it has been difficult to make definitive therapeutic recommendations regarding adjuvant RT.…”
mentioning
confidence: 99%