Submandibular salivary disease: a proposed allergic aetiology

Harkness, P.

doi:10.1017/s0022215100129275

Cited by 14 publications

(15 citation statements)

References 5 publications

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“…[5,6] In this study, it was noted that 23 case reports specifically referenced the presence of food-related exacerbations; 4 case reports established that the symptoms were not food related; and 14 case reports made no mention of food-related symptoms. It is, therefore, deduced that food allergies should be sought out in a majority of patients.…”

Section: Discussionmentioning

confidence: 99%

“…[3,4] The etiology of this disease remains unknown although the most accepted hypothesis is that it is an allergic process. [4–6] Treatment varies according to the severity of the disease, nevertheless initial supportive treatment with massages and hydration is recommended in conjuncture with the use of antihistamines and/or corticosteroids. In refractory cases, corticosteroid infiltration and dilation of the parotid duct has been done.…”

Section: Introductionmentioning

confidence: 99%

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Sialodochitis fibrinosa (kussmaul disease) report of 3 cases and literature review

Robles¹,

Álvarez

Sanchinel

et al. 2016

Medicine

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Background:Sialodochitis fibrinosa is a rare disease which is characterized by recurring episodes of pain and swelling of the salivary glands due to the formation of mucofibrinous plugs. Analytic studies ascertain elevated levels of eosinophils and immunoglobulin E (IgE). Imaging studies such as magnetic resonance imaging (MRI) and sialography reveal dilation of the main salivary duct (duct ectasia). Treatment is initially supportive, consisting of compressive massages, and use of antihistamines and/or corticosteroids.Material and methods:In the following, 3 cases of sialodochitis fibrinosa are presented which were diagnosed in a third level hospital during the period of 2008 and 2016, as well as a literature review of all cases reported to our knowledge.Results:Of the 41 cases found, including the 3 of this article, 66% were women with an average age of 45 years old. However, 75% of reported cases were of Japanese heritage. Involvement of the parotid glands was more frequent than the submandibular glands. In more than half of all cases treatment with compressive massages, antihistamines and/or corticosteroids was effective.Conclusion:Clinicians should consider sialodochitis fibrinosa as a diagnostic possibility when presented with cases of recurring parotid and submandibular gland tumescence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sialodochitis fibrinosa (kussmaul disease) report of 3 cases and literature review

Robles¹,

Álvarez

Sanchinel

et al. 2016

Medicine

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“…Harkness presented two similar cases of recurrent submandibular gland swelling that could not be attributed to any known disease process. [4] Histological examination of one patient showed dense eosinophilic infiltration, while the second patient had peripheral eosinophilia of 8%. Both of these patients demonstrated a decrease in swelling and symptoms in response to antihistamines, lending further credence to an underlying allergic mechanism.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Kussmaul Disease (Sialodochitis Fibrinosa)

2015

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Sialodochitis fibrinosa (or commonly known as Kussmaul Disease) is a rare salivary gland disease characterized by recurrent salivary gland swelling and pain as a result of mucofibrinous plugs. Typically patients have a history of multiply recurrent glandular swelling, dehydration and/or decreased salivary flow, thick secretions from Stensen’s or Wharton’s duct, and/or history of allergic diseases. Retention of mucofibrinous plugs may lead to acute suppurative parotitis and chronic sialadenitis ultimately. The diagnosis is one of exclusion, and treatment is based on symptomatology and largely supportive.

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“…Moreover, allergy has been implicated as a cause of parotid and submandibular gland swelling 8 . In one case of submandibular gland swelling, which was believed to have an allergic etiology, the patient had eosinophilia and severe acute and chronic sialadenitis with dense eosinophil infiltrates 8 . Waldbott et al 9 .…”

Section: Discussionmentioning

confidence: 99%

“…8 In one case of submandibular gland swelling, which was believed to have an allergic etiology, the patient had eosinophilia and severe acute and chronic sialadenitis with dense eosinophil infiltrates. 8 Waldbott et al . 9 reported three patients who experienced recurrent parotid swelling after the ingestion of certain foods.…”

Section: Discussionmentioning

confidence: 99%

Multiple granulomatous inflammation in the minor salivary glands: A proposed new entity, allergic granulomatous sialadenitis

Irié

Maeda

Aida

et al. 2004

Pathology International

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We report a patient who presented with multiple small submucosal nodules with granulomatous inflammation in the minor salivary glands of the oral cavity. A 43-year-old woman presented with a 1-week history of multiple small submucosal nodules in her oral cavity after having taken medicine for abdominal pain. The patient did not have a history of fever, rectal bleeding, skin lesions or arthritis, but did have a history of drug allergy and bronchial asthma. Histopathological examination of the submucosal nodules showed sialadenitis with marked infiltration of lymphocytes, eosinophilic cells, macrophages and Langhans-type or foreign-body-type multinucleate giant cells. The macrophages tended to be aggregated and appeared to have caused immature granuloma formation without caseous necrosis. Degranulated eosinophilic cells were numerous. Sarcoidosis, Crohn's disease, tuberculosis and atypical mycobacterial infection were not identified by medical examination. Three weeks after discontinuing the medication the patient was seen again at a follow-up visit. Multiple submucosal small nodules and other symptoms were not evident at that time. This case report may represent a new entity of salivary gland disease that we tentatively refer to as 'allergic granulomatous sialadenitis'.

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Submandibular salivary disease: a proposed allergic aetiology

Cited by 14 publications

References 5 publications

Sialodochitis fibrinosa (kussmaul disease) report of 3 cases and literature review

Sialodochitis fibrinosa (kussmaul disease) report of 3 cases and literature review

A Rare Case of Kussmaul Disease (Sialodochitis Fibrinosa)

Multiple granulomatous inflammation in the minor salivary glands: A proposed new entity, allergic granulomatous sialadenitis

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