Submental lymph node metastasis from invasive ductal breast carcinoma

Al-Benna, Sammy; Tzakas, Elias

doi:10.1007/s00404-011-2018-3

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…The incidence of NM of 3% in the present study is comparable to that previously reported at 4% (13). BC can metastasize to different head and neck regions, although the most common site is the supraclavicular fossa (14)(15)(16). A recent study (17) explored patterns of metastasis to the head and neck region and demonstrated extreme variability in the clinical and pathological features of BC metastasis.…”

Section: Discussionsupporting

confidence: 87%

Early detection of neck lymph node metastases in breast cancer patients: the role of ultrasound and fine needle biopsy

Rebol

Balon

Kokol

et al. 2021

AMB

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Purpose: To analyze the distribution and pattern of neck metastasis in breast cancer (BC) patients. Methods: The clinicopathological characteristics of 41 patients with BC and confirmed neck metastasis (NM) treated at our institution between 2010 and 2016 were retrospectively analyzed by reviewing medical records. The diagnosis of NM was confirmed by fine needle aspiration cytology, and node localization was classified into six levels according to Robbins' classification. Statistical analysis was performed using descriptive statistics, Pearson’s correlation and multidimensional correspondence analysis. All statistical analyses were performed using SPSS. Results: At the time of neck ultrasonography, 34 (85%) patients had developed distant metastases, 38% of the patients were asymptomatic, and 17% had no palpable nodes. The average time from BC diagnosis to the development of NM was 5.8 years (range, 0–26 years). Lymph node metastasis occurred at level V in 53.7% of patients and level IV in 19.5% of patients. Two-level involvement occurred in 9.8% and one-level involvement in 75% of patients. There were significant correlations (p < 0.01) between patient age andtime from diagnosis to development of NM, age and stage of the disease, and stage and appearance of conglomerates. Conclusion: The most common site of NM from BC was next to the supraclavicular fossa, although they occurred at other levels. Ultrasonography combined with fine needle aspiration cytology is effective for the detection of early occult metastatic lymph nodes.

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Section: Discussionsupporting

confidence: 87%

Early detection of neck lymph node metastases in breast cancer patients: the role of ultrasound and fine needle biopsy

Rebol

Balon

Kokol

et al. 2021

AMB

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“…Our research strategy revealed a total of 88 relevant papers 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90…”

Section: Resultsmentioning

confidence: 99%

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Aga,

Shreevats,

Gupta

et al. 2024

Avicenna J Med

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Background Breast cancer is one of the most lethal neoplasms causing death. Oral cavity is the rare site of distant metastasis from breast cancer. Very little research has been conducted to date to analyze breast cancer as the sole primary source of metastasis to the oral soft tissues. The goal of this study was to examine the published cases of oral soft tissue metastasis from breast cancer as the only primary source to date. Methods An electronic search of the published literature was performed without publication year limitation in PubMed/Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like (“Breast cancer”, OR “Breast carcinoma”) AND (“Metastasis” OR “Metastases”), And (“Oral soft tissues” OR “Tongue” OR “Palate” OR “Tonsil” OR “Buccal mucosa” OR “Floor of mouth” OR “Vestibule” OR “Salivary glands”). We also searched all related journals manually. The reference list of all articles was also checked. Results Our research revealed 88 relevant papers (September 1967–September 2023) with 96 patients in total. The most predominant oral soft tissues involved were salivary glands followed by the gingiva, tonsils, tongue, and buccal mucosa. A total of 23% of patients died with an average survival time of 1 to 15 months. Conclusions Oral soft tissue metastasis from breast cancer is a rare event and has a bad prognosis. More cases need to be published to raise awareness of these lesions.

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“…The new therapies developed, during last decades, to be less harmful for the patients, as surgery and chemotherapy, were found to have, in too many cases, a relatively low successful rate and a high risk of reoccurrence [ 2 ]. The main problem with therapeutic molecules, including those from natural sources, concerns their insufficient selectivity and consequently their deleterious effects towards healthy cells [ 3 , 4 ]. Moreover, cancerous cells develop frequently mechanisms of resistance and particularly through the pumping of anticancer drugs outside their cytosol [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging

Loiseau¹,

Augenstreich²,

Marchand³

et al. 2016

PLoS ONE

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Antimicrobial peptides can be used as therapeutic agents against cancer cells. Warnericin RK and derivatives (WarnG20D and WarnF14V) were tested on various, solid tumor or leukemia, cancer cells. These peptides appeared to be cytotoxic on all the cell types tested, cancerous as well healthy, but very interestingly displayed no deleterious effect on healthy mononuclear cells. The mode of action of the peptide was proposed to be membranolytic, using chemical Raman imaging. Addition of peptide induced a large disorganization of the membrane leading to the loss of the content of inner compartments of Jurkat cell, whereas no effect was observed on the healthy mononuclear cells. The less hemolytic peptides WarnG20D and WarnF14V could be good candidates for the leukemia treatment.

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Submental lymph node metastasis from invasive ductal breast carcinoma

Cited by 5 publications

References 25 publications

Early detection of neck lymph node metastases in breast cancer patients: the role of ultrasound and fine needle biopsy

Early detection of neck lymph node metastases in breast cancer patients: the role of ultrasound and fine needle biopsy

Oral Soft Tissue Metastasis from Breast Cancer as the Only Primary Source: Systematic Review

Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging

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