Submicron Particles of SBA-15 Modified with MgO as Carriers for Controlled Drug Delivery

Abstract

Controlled drug delivery technology represents one of the most rapidly advancing areas of biomedical science contributed by chemists and chemical engineers to health care. Controlled delivery systems offer significant advantages over conventional dosage forms, in terms of enhanced efficiency of medicine, and improved patient compliance and convenience over as the efficiency of medicine. The method by which a drug is delivered can have a significant effect on its therapeutic efficacy. The controlled drug release process is attractive and has been widely and intensively studied. Much of this work involves polymers to enable the drug to be delivered at relative constant rate by diffusion control from polymer or polymer composites over time.1-7) The drug is deposited by means of direct compression, coating, wet granulation, or mechanical mixture of both matrix and drug. These methods have in general the disadvantage of non-uniform distribution, which can influence the release rate between different drug compositions. Therefore, much improvement in this field would be expected if chemically homogeneous materials possessing uniformly arranged porosity to accept organic guest molecules are made available.Novel ordered mesoporous silica materials with biocompatible amorphous pore walls fulfill these requirements and have good potential for biomedical applications of drug delivery and tissue regeneration. [8][9][10] The large pore volume allows high drug loading into the ordered matrix. The large surface area of the internal surface can be modified according to specific purposes for different drugs association on the surface of matrix. Since Vallet-Regi and co-workers 11) reported that MCM-41 loaded ibuprofen could be sustained-release in 80 h, mesoporous silica materials have attracted great attention to be a potential controlled drug delivery system. Organic modified MCM-41 with functional groups on the surface could further decrease the delivery rate of ibuprofen. [12][13][14][15] Among mesoporous materials, SBA-15 possesses a hexagonal array of mesopores 6.0-20 nm in diameter, which is much larger than the 3.0-nm pores characteristic of the MCM-41 and MCM-48. Therefore, SBA-15 mesoporous materials could be modified with various surface functional groups and still preserve the large pore channels and surface areas for drug adsorption and desorption. [16][17][18][19] It is expected to provide greater versatility for the delivery of drug molecules, whereupon the release rate depends to the large extent on the surface properties of drug carrier. The most common morphology of SBA-15 used is noodle-like fiber bundles of several tens of micrometers in length. 20) Particle size and morphology are among the significant factors to affect the uptake of formulated drugs through the intestine wall to body fluids for controlled delivery. Thus, it is important to develop mesoporous silica SBA-15 with submicron particle size and having new possibilities for incorporating biological agents within the silica host and for controlling t...

Formulation development and statistical optimization of ibuprofen-loaded polymethacrylate microspheres using response surface methodology

“…4) of ibuprofen depicted a typical profile of a pure crystalline compound with a sharp endothermic peak (t peak at 79.04˚C, ΔH Fus 126.276 J/g) owing to its fusion and it complied with the reported data (Tayade and Kale, 2004;Shen et al, 2007). …”

Investigating the Physical Properties of Sintered Alumina in the Presence of MgO Nanopowder

“…Among the oxide compounds, magnesium oxide (MgO) has interesting properties and is employed in industrial applications [11][12][13][14][15][16][17][18][19][20]. In 1961, Coble investigated the effect of a small amount of magnesia on sintering of alumina for the first time and they reported that the adding of MgO less than 0.25 wt% led to obtaining a density near the theoretical The differential thermal analysis (DTA) of dried sol-gel product at 100 ∘ C for 24 hrs [22].…”

Synthesis of magnesium oxide particles with stacks of plates morphology

“…Magnesium oxide possesses interesting properties and potential applications in the areas such as pharmaceuticals [1], electrooptical devices [2], fluorescent displays [3], ferroelectric materials [4], etc. Magnesium oxide is also used in superconducting films as a substrate [5], and lithium ion batteries [6].…”