Submicron polycaprolactone particles as a carrier for imaging contrast agent for in vitro applications

Iqbal, Muhammad; Robin, Sophie; Humbert, P.; Viennet, Céline; Agusti, Géraldine; Fessi, Hatem; Elaı̈ssari, Abdelhamid

doi:10.1016/j.colsurfb.2015.09.045

Cited by 10 publications

(4 citation statements)

References 41 publications

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“…SEM images also confirm interparticle bridging, which was due to PVA presence in the formulation, as it is challenging to washout PVA completely. The smooth surface of these particles also supports the assumption of acriflavine release by matrix erosion (Iqbal et al., 2015 ).…”

Section: Resultssupporting

confidence: 67%

Polycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization andin vivoburn wound healing activity

et al. 2022

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Cutaneous burn wounds are a common and troublesome critical issue of public health. Over the last decade, many researchers have investigated the development of novel therapeutic modalities which are capable of fully regeneration and reinstatement of structure and function of the skin with no or limited scar formation. Novel pharmaceutical carriers are offering a potential platform to deliver the drug effectively and to overcome the limitation associated with conventional wound dressings. The aim of this study was to investigate a pharmaceutical acriflavine-loaded polycaprolactone nanoemulsion (ACR-PCL-NE) for burn wound healing. Nanoemulsion was prepared by using the double emulsion solvent evaporation technique and it was subjected to thermodynamic stability testing, droplet size, polydispersity, zeta potential, pH, and surface morphology analysis. The in vivo study was performed to evaluate the efficacy of nanoemulsion using Sprague-Dawley rats as an animal model. The results of this study revealed that the optimized nanoemulsion was stable and had desirable physicochemical properties. The pH was about 4.02 at 25 °C and the particle size was found to be in the range of 302 ± 4.62 nm while the zeta potential was −7.8 ± 1.22 mV and the polydispersity index of 0.221 ± 0.017. The wound regeneration process was evaluated in vivo by different techniques, the formulation group (FG) showed high wound healing potential as compared to the standard group (SD) and control group (CG). These findings reveal that this nanoemulsion formulation can be used effectively for wound healing.

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Section: Resultssupporting

confidence: 67%

Polycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization andin vivoburn wound healing activity

et al. 2022

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“…The SEM images show that the ACR-PCL-NPs were smooth on the surface with a spherical shape. The smoothness of the ACR-PCL-NPs’ surface supports the assumption that encapsulated active drug-release may be due to matrix erosion [ 46 ]. Additionally, bridging between particles can be seen in SEM images ( Figure 5 ), and these bridges may be associated with the sticky nature of the PVA used in these formulations.…”

Section: Resultsmentioning

confidence: 65%

Development and Optimization of Acriflavine-Loaded Polycaprolactone Nanoparticles Using Box–Behnken Design for Burn Wound Healing Applications

et al. 2021

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Nanoparticles are used increasingly for the treatment of different disorders, including burn wounds of the skin, due to their important role in wound healing. In this study, acriflavine-loaded poly (ε-caprolactone) nanoparticles (ACR-PCL-NPs) were prepared using a double-emulsion solvent evaporation method. All the formulations were prepared and optimized by using a Box–Behnken design. Formulations were evaluated for the effect of independent variables, i.e., poly (ε-caprolactone) (PCL) amount (X1), stirring speed of external phase (X2), and polyvinyl alcohol (PVA) concentration (X3), on the formulation-dependent variables (particle size, polydispersity index (PDI), and encapsulation efficiency) of ACR-PCL-NPs. The zeta potential, PDI, particle size, and encapsulation efficiency of optimized ACR-PCL-NPs were found to be −3.98 ± 1.58 mV, 0.270 ± 0.19, 469.2 ± 5.6 nm, and 71.9 ± 5.32%, respectively. The independent variables were found to be in excellent correlation with the dependent variables. The release of acriflavine from optimized ACR-PCL-NPs was in biphasic style with the initial burst release, followed by a slow release for up to 24 h of the in vitro study. Morphological studies of optimized ACR-PCL-NPs revealed the smooth surfaces and spherical shapes of the particles. Thermal and FTIR analyses revealed the drug–polymer compatibility of ACR-PCL-NPs. The drug-treated group showed significant re-epithelialization, as compared to the controlled group.

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“…Hence, synthesis of MNPs with porous structure is a particular solution to achieve higher drug loading capacities [11][12][13]. Moreover, MNPs could be coated by different thermosensitive agents to protect the encapsulated compounds from uncontrolled leakage [7,8,[14][15][16]. When the particles reach the target tumor, the produced thermal energy dissociates the protective shell and facilitates release of the therapeutic load [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Polyethylene glycol-coated porous magnetic nanoparticles for targeted delivery of chemotherapeutics under magnetic hyperthermia condition

Dabbagh

Hedayatnasab

Karimian

et al. 2018

International Journal of Hyperthermia

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Submicron polycaprolactone particles as a carrier for imaging contrast agent for in vitro applications

Cited by 10 publications

References 41 publications

Polycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization andin vivoburn wound healing activity

Polycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization andin vivoburn wound healing activity

Development and Optimization of Acriflavine-Loaded Polycaprolactone Nanoparticles Using Box–Behnken Design for Burn Wound Healing Applications

Polyethylene glycol-coated porous magnetic nanoparticles for targeted delivery of chemotherapeutics under magnetic hyperthermia condition

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