Submicroscopic crystals in osteoarthritic synovial fluids.

Swan, A; Chapman, B. L.; Heap, P. F.; Seward, H; Dieppe, Paul

doi:10.1136/ard.53.7.467

Cited by 70 publications

(50 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lavage of the joint clears fragments of cartilage 19 and calcium phosphate crystals. 62 Harwin 28 and other groups 16,17,56 have found that lavage and debridement are beneficial for a select group of patients presenting with acute pain, specific localized mechanical symptoms of locking or catching, minimal malalignment, and no previous history of surgery, 48 as opposed to patients with global arthritic changes. 31 Jackson and Dieterichs 33 found that lavage and debridement provide significant relief in patients with osteoarthritis if the intervention is performed during the acute stage of degeneration.…”

Section: Palliative Technique: Arthroscopic Lavage and Debridementmentioning

confidence: 99%

The Basic Science and Surgical Treatment Options for Articular Cartilage Injuries of the Knee

Tetteh¹,

Bajaj²,

Ghodadra³

2012

Journal of Orthopaedic & Sports Physical Therapy

View full text Add to dashboard Cite

Synopsis The complex structure of articular cartilage allows for diverse knee function throughout range of motion and weight bearing. However, disruption to the structural integrity of the articular surface can cause significant morbidity. Due to an inherently poor regenerative capacity, articular cartilage defects present a treatment challenge for physicians and therapists. For many patients, a trial of nonsurgical treatment options is paramount prior to surgical intervention. In instances of failed conservative treatment, patients can undergo an array of palliative, restorative, or reparative surgical procedures to treat these lesions. Palliative methods include debridement and lavage, while restorative techniques include marrow stimulation. For larger lesions involving subchondral bone, reparative procedures such as osteochondral grafting or autologous chondrocyte implantation are considered. Clinical success not only depends on the surgical techniques but also requires strict adherence to rehabilitation guidelines. The purpose of this article is to review the basic science of articular cartilage and to provide an overview of the procedures currently performed at our institution for patients presenting with symptomatic cartilage lesions. J Orthop Sports Phys Ther 2012;42(3):243–253. doi:10.2519/jospt.2012.3673

show abstract

Section: Palliative Technique: Arthroscopic Lavage and Debridementmentioning

confidence: 99%

The Basic Science and Surgical Treatment Options for Articular Cartilage Injuries of the Knee

Tetteh¹,

Bajaj²,

Ghodadra³

2012

Journal of Orthopaedic & Sports Physical Therapy

View full text Add to dashboard Cite

show abstract

“…It has been suggested recently that many OA fl uids contain clusters of BCP crystals that are too small or too few in number to be identifi ed by conventional techniques [4]. Ample data support the role of BCP crystals in cartilage degeneration.…”

Section: Clinical Aspectsmentioning

confidence: 97%

Point: Hydroxyapatite crystal deposition is intimately involved in the pathogenesis and progression of human osteoarthritis

McCarthy

Cheung²

2009

Curr Rheumatol Rep

View full text Add to dashboard Cite

The cause of osteoarthritis (OA), the most common form of arthritis, is most likely multifactorial. No drug exists to slow the progression or reverse OA disease progression. Ample data support a key role of calcium-containing crystals, such as hydroxyapatite, in OA pathogenesis. The presence of these crystals, far higher in OA than in any other form of arthritis, correlates with the degree of radiographic degeneration. Calcium-containing crystals have potent biologic effects in vitro that emphasize their pathogenic potential. OA-associated matrix and chondrocyte alterations play an intimate role in the crystal deposition process. A major difficulty has been the lack of a simple technique for crystal identification in affected joints. Enhanced effort is needed to establish calcium-containing crystals as a therapeutic target in OA, as current data suggest an intimate association in its pathogenesis and progression.

show abstract

“…too small or too few in number to be identified by conven tional techniques [7]. There are as yet no studies as to whether such rare or small crystals have different clinical implications.…”

Section: The Detection and Identification Of Crystalsmentioning

confidence: 98%

Crystal deposition and osteoarthritis

Ölmez

1999

Curr Rheumatol Rep

View full text Add to dashboard Cite

Calcium-containing crystals are commonly found in osteoarthritic (OA) joints. Although most often found in advanced OA, some calcium pyrophosphate dihydrate and apatite can be present in early stages. These crystals could be factors in pathogenesis of OA and even more likely in the progression of disease. Calcium pyrophosphate dihydrate apatites and other calcium phosphates can be mitogenic, can stimulate the release of metalloproteases, and might have mechanical abrasive effects.

show abstract

Submicroscopic crystals in osteoarthritic synovial fluids.

Abstract: Objectives-To investigate the hypothesis that synovial fluid (SF) from patients with osteoarthritis

Cited by 70 publications

References 10 publications

The Basic Science and Surgical Treatment Options for Articular Cartilage Injuries of the Knee

The Basic Science and Surgical Treatment Options for Articular Cartilage Injuries of the Knee

Point: Hydroxyapatite crystal deposition is intimately involved in the pathogenesis and progression of human osteoarthritis

Crystal deposition and osteoarthritis

Contact Info

Product

Resources

About