Submillimeter Choroidal Melanoma Detection by Enhanced Depth Imaging Optical Coherence Tomography in a Patient With Oculodermal Melanocytosis

Daitch, Zachary; Shields, Carol L.; Say, Emil Anthony T.; Mashayekhi, Arman; Shields, Jerry A.

doi:10.1097/icb.0000000000000162

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…As OCT has evolved, greater resolution and depth of imaging have led to new applications within ocular oncology [2,3,4]. Handheld spectral-domain OCT (HHSD OCT) allows for imaging in the supine position [5] and therefore is becoming a useful tool in the care of children with retinoblastoma [6].…”

Section: Introductionmentioning

confidence: 99%

Detection and Intraretinal Localization of an ‘Invisible' Retinoblastoma Using Optical Coherence Tomography

Berry

Cobrinik

Kim³

2015

Ocul Oncol Pathol

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Purpose: To report the use of handheld spectral-domain optical coherence tomography (HHSD OCT) to identify and define the intraretinal location of a small retinoblastoma that was not detectable by indirect ophthalmoscopy. Methods: This is a retrospective case report of a tumor identified with HHSD OCT in a single patient. Results: A 7-week-old male was diagnosed with unilateral group E retinoblastoma in the right eye. An enucleation was completed successfully with histopathologic confirmation of the diagnosis. The normal left eye was monitored for the development of retinoblastoma, and 10 weeks after diagnosis, three new small retinoblastomas were noted in the posterior pole. Identification of the smallest of the three tumors was facilitated by HHSD OCT; it was adjacent to the optic nerve head, and involved the outer nuclear layer, outer plexiform layer, and inner nuclear layer, with the inner retina draping over the tumor. Conclusion: HHSD OCT can aid the ocular oncologist in the identification of very small retinoblastomas before they are visible to the eye, which allows for earlier and potentially vision-sparing treatment of these lesions. Additionally, the ability to identify these very small tumors and to localize them anatomically within the retinal layers may aid in our understanding of retinoblastoma tumorigenesis.

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Section: Introductionmentioning

confidence: 99%

Detection and Intraretinal Localization of an ‘Invisible' Retinoblastoma Using Optical Coherence Tomography

Berry

Cobrinik

Kim³

2015

Ocul Oncol Pathol

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“…There are sparse reports in the literature of patients of uveal metastasis initially diagnosed as CSC. These have been mainly due to metastatic cutaneous melanoma [ 4 , 5 ]. Furthermore, patients presenting with MEK-inhibitor-associated retinopathy have been similarly thought to have CSC [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Recurrence of Pancreatic Cancer Presenting as Choroidal Metastasis: A Case Report

Smith

Tran

2021

Case Rep Ophthalmol

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A patient initially diagnosed as having central serous chorioretinopathy (CSC) presented to a clinic with recurrence of pancreatic cancer manifesting as choroidal metastasis. He was initially diagnosed with CSC by a local ophthalmologist 8 weeks earlier and subsequently presented to our clinic for second opinion after further loss of vision. His medical history was significant for locally advanced pancreatic cancer that was resected by pancreaticoduodenectomy and was treated with adjuvant Folfirinox chemotherapy that was completed 12 months earlier. On examination, there was a large serous retinal detachment overlying a large pale ill-defined elevated choroidal lesion. A diagnosis of choroidal metastasis from recurrence of his pancreatic cancer was made. The diagnosis of choroidal metastasis of his pancreatic cancer represented recurrence of his pancreatic cancer that is associated with high mortality. Early recognition by clinical assessment may allow timely management with chemotherapy and radiation, and potentially prolong survival.

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“…Like the skin, melanomas developing from the ocular aspect of nevus of Ota appear to be more common in females (Table 2). Twelve of the 16 cases of ocular melanoma occurred in women, suggesting an estimated 3 : 1 female‐to‐male ratio 13,18‐32 . The melanomas were reported in adult patients, with no pediatric cases published.…”

Section: Introductionmentioning

confidence: 99%

“…All patients without metastasis had great prognoses regardless of treatment modality. The most commonly offered treatment was enucleation or extirpation of the orbit, however multiple patients opted for plaque radiotherapy after declining the former options 23,29 . Interestingly, the majority of cases that received plaque radiotherapy saw no recurrences within the follow‐up periods provided, aside from one case that recurred 3 years later, necessitating enucleation at that time with no recurrences thereafter 32 .…”

Section: Introductionmentioning

confidence: 99%

Melanoma in the setting of nevus of Ota: a review for dermatologists

et al. 2020

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Nevus of Ota, also known as oculodermal melanocytosis or nevus fuscoceruleus ophthalmomaxillaris, is a benign dermal melanocytic nevus that most commonly affects Asian women. While the lesion is largely a cosmetic concern, it has the potential to undergo malignant transformation to melanoma. Patients with nevus of Ota often present to a dermatologist at some point for examination or removal with laser therapy. Therefore, it is important for dermatologists to understand the cutaneous and extracutaneous risks these lesions carry and how they may present to further optimize management and appropriate referrals. This review describes the demographic, clinical, and prognostic features of melanoma in the setting of nevus of Ota, divided by the nature of the primary melanoma: cutaneous, orbital, intracranial.

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Submillimeter Choroidal Melanoma Detection by Enhanced Depth Imaging Optical Coherence Tomography in a Patient With Oculodermal Melanocytosis

Cited by 8 publications

References 17 publications

Detection and Intraretinal Localization of an ‘Invisible' Retinoblastoma Using Optical Coherence Tomography

Detection and Intraretinal Localization of an ‘Invisible' Retinoblastoma Using Optical Coherence Tomography

Recurrence of Pancreatic Cancer Presenting as Choroidal Metastasis: A Case Report

Melanoma in the setting of nevus of Ota: a review for dermatologists

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