Submillimeter-wave phonon modes in DNA macromolecules

Woolard, Dwight L.; Globus, Tatiana; Gelmont, Boris; Bykhovskaia, Maria; Samuels, Alan C.; Cookmeyer, Donna; Hesler, Jeffrey L.; Crowe, T.W.; Jensen, James O.; Jensen, Janet L.; Loerop, William R.

doi:10.1103/physreve.65.051903

Cited by 96 publications

(59 citation statements)

References 26 publications

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“…Although theoretical simulations indicate a large number of normal modes in this frequency range, 19 with typical THz TDS spectrometers these modes are most often not resolved, but a broad featureless absorption is observed. Despite the drawback induced by the lack of characteristic features in the spectra of such larger, complex biomoleules, THz-TDS can still be a versatile tool for biosensing.…”

Section: Large Complex Bimoleculesmentioning

confidence: 92%

Biosensing with T-ray spectroscopy

Fischer¹,

Helm²,

Abbott³

2007

Biophotonics 2007: Optics in Life Science

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In the recent years, it has been shown that terahertz (or T-ray) spectroscopy is a versatile tool for biosensing and safety applications. This is due to the fact that the THz-spectra of many biomolecules show very characteristic, distinct spectroscopic features. Furthermore, most non-metallic packaging materials are nearly transparent in this frequency range (0.1 -6 THz, 3 cm −1 -200 cm −1 ), so that it is possible to non-invasively identify even sealed substances like pharmaceuticals, illicit drugs or explosives by their spectroscopic signatures. This opens a significant potential for a wide range of applications from quality control of pharmaceutical substances via safety applications through to biomedical applications.The individual spectroscopic features below approximately 5 THz that spurred the increased world wide interest in T-ray spectroscopy are mainly due to intermolecular rather than intramolecular vibrations in the polycrystalline samples. The spectra of more complex biomolecules, like proteins and nucleotides, typically show less or even no sharp features, due to the lack of long-range intermolecular order. Furthermore, due to the typically significantly smaller sample amount, the signal to noise ratio is strongly increased. Water shows a strong absorption in this frequency range, which all together makes real biomedical applications of T-ray spectroscopy rather difficult. Yet, by combining a careful sample preparation, novel experimental techniques and an advanced signal processing of the experimental data we can still clearly distinguish between even complex biomolecules and therefore demonstrate the potential the technique holds for biomedical applications.

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Section: Large Complex Bimoleculesmentioning

confidence: 92%

Biosensing with T-ray spectroscopy

Fischer¹,

Helm²,

Abbott³

2007

Biophotonics 2007: Optics in Life Science

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show abstract

“…Unfortunately these reports contained irreproducible and/or conflicting observations which likely resulted in false assignments because they did not address one chief artifact in this frequency range, namely, multiple reflection effects or Fabry-Perot etalon (Crowe et al 2004;Edwards et al 1984;Globus et al 2002Globus et al , 2006Parthasarathy et al 2005;Woolard et al 2002). Fabry-Perot etalon is an interference between copropagating light beams arising from reflections at the sample/ window surfaces.…”

Section: Crystal Anisotropy Terahertz Microscopymentioning

confidence: 99%

Terahertz optical measurements of correlated motions with possible allosteric function

Niessen

Markelz

2015

Biophys Rev

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A suggested mechanism for allosteric response is the distortion of the energy landscape with agonist binding changing the protein structure's access to functional configurations. Intramolecular vibrations are indicative of the energy landscape and may have trajectories that enable functional conformational change. Here, we discuss the development of an optical method to measure the intramolecular vibrations in proteins, namely, crystal anisotropy terahertz microscopy, and the various approaches which can be used to identify the spectral data with specific structural motions.

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“…However, the rewards of exploiting this gap are great, owing to the diverse applications of THz radiation. For example, the vibrational breathing modes of many large molecules occur in the THz domain making THz spectroscopy a potentially powerful tool for the identification and characterization of biomolecules [8][9][10][11][12]. Furthermore, the non-ionizing nature of THz radiation means that it is seen by many as the future of imaging technology, and it also has promising applications in biomedicine and biosensing.…”

Section: Introductionmentioning

confidence: 99%

Terahertz science and technology of carbon nanomaterials

2014

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Abstract. The diverse applications of terahertz radiation and its importance to fundamental science makes finding ways to generate, manipulate, and detect terahertz radiation one of the key areas of modern applied physics. One approach is to utilize carbon nanomaterials, in particular, single-wall carbon nanotubes and graphene. Their novel optical and electronic properties offer much promise to the field of terahertz science and technology. This article describes the past, current, and future of the terahertz science and technology of carbon nanotubes and graphene. We will review fundamental studies such as terahertz dynamic conductivity, terahertz nonlinearities, and ultrafast carrier dynamics as well as terahertz applications such as terahertz sources, detectors, modulators, antennas, and polarizers.

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Submillimeter-wave phonon modes in DNA macromolecules

Cited by 96 publications

References 26 publications

Biosensing with T-ray spectroscopy

Biosensing with T-ray spectroscopy

Terahertz optical measurements of correlated motions with possible allosteric function

Terahertz science and technology of carbon nanomaterials

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