Submucosal adenoma of the esophagus: case report and review of the literature

Hayashi, Yoshinori; Iwakiri, Katsuhiko; Kagawa, Takahide; Hirakawa, Tsunehisa; Sakamoto, Choitsu; Arai, Tomio; Takubo, Kaiyo

doi:10.1007/s10388-004-0016-2

Cited by 3 publications

(11 citation statements)

References 16 publications

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“…1,16 The ESGDAs have a similar distribution pattern. 9 These clinical characteristics along with the distinct IHC staining pattern are helpful in diagnosis. It is unclear whether all these symptoms have been caused by the ESGDA itself or by the esophagitis related to gastroesophageal reflux disease (GERD).…”

Section: Discussionmentioning

confidence: 99%

“…It was showed that the luminal duct lining cells and basal cells were positive for CK7 and p63, respectively. 9 However, the ESGDA was adequately described in case reports. The frequency of Ki-67 positive proliferating cells was very low (1%) (Fig.…”

Section: Pathological Featuresmentioning

confidence: 99%

“…1 Although they appeared to vary in number and/or distribution among individuals, prior studies noted that SMGs clustered at either the proximal or distal esophagus, organizing into longitudinal rows parallel to the long axis of the organ. [3][4][5][6][7][8][9][10][11] Series study focusing on histopathological features of this lesion has not been reported. It was usually described in case reports and named variously.…”

Section: Introductionmentioning

confidence: 99%

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Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature

Nie

Shen

et al. 2015

Dis Esophagus

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Esophageal submucosal gland duct adenoma (ESGDA) is a rare tumor. The clinicopathological features of the ESGDA and its precursor lesion have not been comprehensively evaluated. In this study, we aimed at delineating the clinicopathological features of the ESGDA and cyst formation of the esophageal submucosal gland duct (ESGD), as well as their correlations and clinical implications. We identified three cases of ESGDA and 16 cases of cyst formation of the ESGD among 786 endoscopic mucosal resection specimens over a 7-year period. The median patient age was 58 years with a male predominance. These lesions were small submucosal bulges locating at the lower esophagus with a size no more than 1 cm. The main microscopic changes of these lesions included content retention, multilayered epithelium or papillary folds of the ESGD and inflammatory cell infiltration, acidophilic degeneration, hyperplasia or atrophy of the acini. The included cases generally showed moderate to severe microscopic esophagitis. The ESGDA was mainly consisted by multiple glandular cysts covered by two layers of cells. Immunohistochemical results showed that the luminal duct lining cells and basal cells were positive for CK7 and p63, respectively. Both of the two layer cells were positive for HMWCK and negative for CK20, p53, CDX2, MUC5AC, MUC6, MUC2 and MUC1. The proliferation index was very low (1%). The diagnostic criteria of the ESGDA were proposed and, the differential diagnosis was discussed. Cyst formation of the ESGD is considered to be the precursor lesion of the ESGDA, because they have overlapping clinicopathological features with progressive relationship. In addition, the ESGDA have close connection with advance of the GERD and, probably, an increased risk of carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Pathological Featuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature

Nie

Shen

et al. 2015

Dis Esophagus

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“…CK20, p63, S100, TTF-1, CD56 and CEA were negative. These histological1 3–5 and immunohistochemical2 features favoured a diagnosis of oesophageal submucosal gland/duct adenoma (OSGA). Repeat endoscopy 3 and 15 months after endoscopic resection showed a scar with no recurrence (figure 5), and he remains asymptomatic.…”

Section: Answermentioning

confidence: 96%

“…Endoscopy typically demonstrates a smooth, broad-based, well-circumscribed lesion1 2 (pedunculated if near the gastro-oesophageal junction4), which can arise anywhere in the oesophagus. EUS may show characteristic features5 and will confirm non-involvement of muscularis propria.…”

Section: Answermentioning

confidence: 99%