Submucosal injection of poly(lactic-co-glycolic acid) microspheres in rabbit bladder as a potential treatment for urinary incontinence and vesicoureteral reflux: preliminary results

Cho, Eui Ri; Kang, Sun-Woong; Park, Heung Jae; Cho, Young‐Sam; Lee, You Sik; Kim, Joon Chul; Kim, Byung Soo

doi:10.1163/1568562054798509

Cited by 9 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vivo , the volume of the hybrid tissues formed by the PLLA microsphere injection was maintained at ∼57% of the original volume at 18 months. This result is promising when compared with injections of either PLGA microspheres34–36 or collagen,45 both of which failed with rapid decreases in volume. The volume conservation can likely be attributed to the slowly degrading microspheres and the ingrowth of host cells that filled the void space between the microspheres.…”

Section: Discussionmentioning

confidence: 92%

“…In our previous studies, we evaluated PLGA microspheres as an injectable bulking substance 34–36. This material was injectable and biocompatible, and induced hybrid tissue formation upon implantation.…”

Section: Discussionmentioning

confidence: 99%

“…An ideal material for injection therapies must be easily injectable, nonmigratory, noninflammatory, volume‐stable, and biocompatible. In our previous study, we evaluated the ability of poly(lactic‐ co ‐glycolic acid) (PLGA) microspheres to overcome the problems of the currently available bulking agents for injection therapies 34–36. PLGA microspheres were easily injectable.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and characterization of conducting polyaniline prepared by laccase‐catalyzed method in sodium dodecylbenzenesulfonate micellar solutions

Streltsov

Морозова

Arkharova

et al. 2009

J of Applied Polymer Sci

View full text Add to dashboard Cite

Enzymatic polymerization of aniline was performed in micellar solutions of the anionic surfactant sodium dodecylbenzenesulfonate (SDBS). High-redox-potential oxidase-laccase isolated from the fungi, Trametes hirsuta, was used as a catalyst in oxidative polymerization of aniline, the atmospheric oxygen serving as an oxidizing agent. It is shown that the laccase-catalyzed reaction of monomer polymerization is kinetically controllable and its mechanism is very distinctly different from that of chemical polymerization.The synthesized PANI/SDBS complexes were characterized using Fourier transform infrared and UV-vis spectroscopy, cyclic voltammetry, termogravimetry, transmission electron microscopy, and electron diffraction. The antistatic properties of the prepared PANI/SDBS composite were also studied.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and characterization of conducting polyaniline prepared by laccase‐catalyzed method in sodium dodecylbenzenesulfonate micellar solutions

Streltsov

Морозова

Arkharova

et al. 2009

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…Poly-lactic-co-glycolic acid (PLGA) microspheres have been considered injectable bulking substances in previous studies [17][18][19] . These studies show that PLGA is biodegradable and biocompatible and induces hybrid tissue formation upon implantation.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of poly-D,L-lactic acid microspheres as subdermal fillers in animals

Lin¹,

Lin²,

Yang³

et al. 2019

PAR

View full text Add to dashboard Cite

Aim: This animal study aims to examine the efficacy and safety of poly-D,L-lactic acid (PDLLA) microspheres as subdermal fillers. Methods: Thirty 2-week-old male Sprague Dawley rats were used as test animals, and 0.5 mL filler solutions were injected into the subdermal tissues on their backs. Groups of five rats were randomly selected and sacrificed for examination on the 2nd, 4th, 8th, 12th, 16th, and 20th weeks after injection. Clinical and histological examinations were performed via the hematoxyline-eosin and immunohistochemical (IHC) staining of injected sites after collecting the injected masses. The body weights of the rats were measured, and the presence of filler substance in other organs was determined. Results: Injected volumes were stable from the 2nd to the 20th week after injection, and no abnormalities were observed around the injection sites. The injected substance did not migrate to the surrounding tissues. In IHC staining experiments, myofibroblasts were observed from the 2nd week, and collagen was detected from the 4th week. Myofibroblast was observed in the spaces between and inside the microspheres in the 8th week after injection, whereas type I collagen was found between and inside the microspheres at 8th and 12th weeks, respectively. Conclusion: The animal experiments confirm the efficacy and safety of injectable PDLLA as a subdermal filler.

show abstract

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

et al. 2006

Self Cite

View full text Add to dashboard Cite

The injection of bulking substances has been proposed as a new therapy to treat urinary incontinence and vesicoureteral reflux. Our previous study demonstrated that poly(lacticco-glycolic acid) (PLGA) microspheres have the potential to serve as a bulking agent for urological injection therapies. Hybrid tissues exhibiting a bulking effect were formed in vivo by PLGA microsphere injection, but long-term volume stability was not proven. In this study, we hypothesized that the biodegradation rate of the bulking substance (polymer microspheres) would affect the duration of volume conservation of the induced hybrid tissue. To test this hypothesis, rapidly degrading 75:25 PLGA microspheres and slowly degrading poly(L-lactic acid) (PLLA) microspheres were used as injectable bulking agents for the injection therapy. In vitro degradation tests showed that the mass losses of PLLA and PLGA were 16 and 96% of the initial masses, respectively, at 30 weeks. PLLA and PLGA microspheres were injected into the subcutaneous dorsum of mice. Both types of microspheres were easily injectable through 24-gauge needles. Histological examinations at various time points indicated that host cells from the surrounding tissues migrated to the spaces between both types of injected microspheres and formed new hybrid tissue structures. Lymphocyte migration was noted around the implanted PLGA and PLLA microspheres, but the inflammatory reaction diminished with time. Importantly, the volume of the PLLA hybrid tissues slowly decreased to 52% of the initial volume at 12 months and maintained that volume until 18 months, whereas the volume of the PLGA hybrid tissues rapidly decreased to 22% at 6 months, and the PLGA hybrid tissues disappeared at 11 months. These results show that the biodegradation rate of the bulking substance may be useful for controlling the duration of volume conservation of the induced hybrid tissue.

show abstract

Submucosal injection of poly(lactic-co-glycolic acid) microspheres in rabbit bladder as a potential treatment for urinary incontinence and vesicoureteral reflux: preliminary results

Cited by 9 publications

References 31 publications

Synthesis and characterization of conducting polyaniline prepared by laccase‐catalyzed method in sodium dodecylbenzenesulfonate micellar solutions

Synthesis and characterization of conducting polyaniline prepared by laccase‐catalyzed method in sodium dodecylbenzenesulfonate micellar solutions

Efficacy and safety of poly-D,L-lactic acid microspheres as subdermal fillers in animals

The effect of microsphere degradation rate on the efficacy of polymeric microspheres as bulking agents: An 18‐month follow‐up study

Contact Info

Product

Resources

About