Suboccipital cerebrospinal fluid and plasma concentrations of somatostatin, neuropeptide Y and beta-endorphin in patients with common migraine

Migraine and neuropeptides

“…After lumbar puncture, the NPY immunoreactivity in the CSF was reported to be higher in migraineurs during the attacks as compared with controls (Valenzuela et al, 2000), whereas another research group did not observe an NPY immunoreactivity elevation in the suboccipital CSF or plasma during attacks and attack-free periods of patients with migraine without aura (Vecsei et al, 1992). In migraine patients with or without aura, the NPY immunoreactivity in the external jugular venous blood did not alter during migraine attacks .…”

“…In an early clinical study, the SST immunoreactivity in the suboccipital CSF was decreased in migraine patients without aura during the attack-free periods, subsequently further decreasing and reaching statistically significant difference as compared with a mixed neuropsychiatric group of patients (Vecsei et al, 1992). CSF obtained by lumbar puncture exhibited a lower SST immunoreactivity level in chronic migraine patients than in controls (Sarchielli et al, 2006a).…”

Role of pituitary adenylate cyclase-activating polypeptide (pacap) in the trigeminovascular system: preclinical and clinical results

“…An earlier study revealed decreased somatostatin-and beta-endorphin-like immunoreactivities of the plasma or CSF obtained by suboccipital puncture, while the neuropeptide Y-like immunoreactivity did not change during the attack period in patients suffering from common migraine [140]. The present MS results confirmed the RIA detection of the presence of PACAP-38 in the rat plasma.…”

Octreotide Dependency and Headache: A Case Report

“…substance P) by the tumor, in combination with activation of endogenous analgesic peptides (e.g. Furthermore, Vecsei et al found a relationship between decreased levels of serum somatostatin and the occurrence of migraine (21). Hypothetically, the release of algogenic substances causes facial and head pain by acting upon the pain-promoting fibers of the trigeminal system.…”