Suboptimal performance of simple noninvasive tests for advanced fibrosis in <scp>C</scp>hinese patients with nonalcoholic fatty liver disease

Xun, Yun; Fan, Jian Gao; Zang, Guo Qing; Liu, Hong; Jiang, Yan; Xiang, Jianyang; Huang, Qian; Shi, Junping

doi:10.1111/j.1751-2980.2012.00631.x

Cited by 38 publications

(34 citation statements)

References 32 publications

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“…Nevertheless, fasting serum FFA constitute the majority of fatty acids delivered to the liver and contribute to liver fat metabolism and accumulation in NAFLD. Third, we used the FIB-4 index for evaluating advanced fibrosis of NAFLD according the studies of Xun YH et al56. FIB-4, a simple non-invasive index composed of readily available routine laboratory tests, can accurately predict advanced fibrosis and cirrhosis in patients with NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

Zhang

Zhao

et al. 2014

Sci Rep

146

100

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High serum free fatty acid (FFA) levels are associated with metabolic syndrome (MS). This study aimed to assess the association of fasting serum FFAs with nonalcoholic fatty liver disease (NAFLD) in a Chinese population. A total of 840 subjects fulfilled the diagnostic criteria of NAFLD and 331 healthy control participants were enrolled in this cross-sectional study. Fasting serum FFA levels and other clinical and laboratory parameters were measured. NAFLD patients had significantly higher serum FFA levels than controls (P < 0.001). Serum FFA levels were significantly and positively correlated with parameters of MS, inflammation indexes, and markers of hepatocellular damage. Elevated serum FFA levels were found in NAFLD subjects with individual components of MS (obesity, hypertriglyceridaemia, and hyperglycaemia). Stepwise regression showed that serum FFA levels were an independent factor predicting advanced fibrosis (FIB-4 ≥ 1.3) in NAFLD patients. Serum FFA levels correlated with NAFLD and could be used as an indicator for predicting advanced fibrosis in NAFLD patients.

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Section: Discussionmentioning

confidence: 99%

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

Zhang

Zhao

et al. 2014

Sci Rep

146

100

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“…Although these tests are slightly less accurate than liver biopsy, these noninvasive tests can reliably exclude advanced fibrosis in a high proportion of NAFLD patients. The markers like NAFLD fibrosis score, FIB-4, and APRI scores can be used for the noninvasive diagnosis of fibrosis [36][37][38] . Some studies have shown that the diagnostic potential of circulating TIMP-1 is higher than that of serum ALT, AST or albumin values [15,16] .…”

Section: Discussionmentioning

confidence: 99%

Tissue Inhibitors of Metalloproteinase-1 and 2 and Obesity Related Non-Alcoholic Fatty Liver Disease: Is There a Relationship?

Abdelaziz¹,

Elbasel²,

Esmat³

et al. 2015

Digestion

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Background/Aims: Non-alcoholic fatty liver disease is a spectrum of clinical conditions, including simple steatosis and non-alcoholic steatohepatitis (NASH). The aim of the study is to evaluate the tissue inhibitors of metalloproteinase-1 and 2 (TIMPs) as noninvasive predictors of NASH. Methods: Three groups were included in the study. Obese patients (n = 30) with normal liver enzymes were included in group I and obese patients (n = 30) with elevated liver enzymes with liver biopsy-based diagnosis of NASH were included in group II. Age-matched subjects (n = 30) formed the control as group III. The lipid profile, liver enzyme levels and levels of TIMPs were compared among all the patients and subjects. Results: Comparison of groups I and II showed significantly elevated levels of TIMP-1 and TIMP-2 in group II as compared to group I (p < 0.05). Similarly, comparison between groups II and III showed significantly increased levels of TIMP-1 and TIMP-2 in group II as compared to group III (p < 0.05). TIMP-1 (sensitivity 96.7%, specificity 100%) and TIMP-2 (sensitivity 93.3%, specificity 100%) showed high accuracy in NASH diagnosis. Conclusion: TIMP-1 and TIMP-2 may be considered noninvasive markers for the diagnosis of NASH.

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“…It has been demonstrated that the FIB-4 score based on several laboratory tests can reliably predict advanced fibrosis and cirrhosis in NAFLD [48]. Recently, Xu et al [49] reported that a high FIB-4 score (≥1.100) is associated with an increased risk of prevalent CKD (eGFR <60 mL/min/1.73 m 2 ) and is an independent predictor of CKD in individuals with ultrasonography-diagnosed NAFLD [49].…”

Section: Discussionmentioning

confidence: 99%

Association Between Urinary Alpha1-Microglobulin Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

Zhang

Zhao

et al. 2017

Ann Nutr Metab

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Background: We aimed to explore the association between urinary alpha₁-microglobulin (A1M) levels and nonalcoholic fatty liver disease (NAFLD) in a Chinese population. Study: We performed a cross-sectional study among 2,215 Chinese who attended their annual health examination at First Affiliated Hospital, College of Medicine, Zhejiang University. Urinary A1M-creatinine ratio and other clinical and laboratory parameters were measured. Results: A total of 20.9% of subjects fulfilled the diagnostic criteria of NAFLD. NAFLD subjects had significantly higher urinary A1M-creatinine ratios. These levels were positively associated with NAFLD prevalence. The association between A1M-creatinine ratio and NAFLD was independent of hyperglycemia status. Stepwise regression showed that urinary A1M-creatinine ratio was significantly associated with the risk for NAFLD. Urinary A1M-creatinine ratio was an independent factor predicting advanced fibrosis (FIB-4 ≥1.3) in NAFLD patients. Conclusions: Our results showed a significant association between urinary A1M-creatinine ratio and NAFLD.

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Suboptimal performance of simple noninvasive tests for advanced fibrosis in Chinese patients with nonalcoholic fatty liver disease

Abstract: Although slightly less accurate than liver biopsy, simple noninvasive tests can reliably exclude advanced fibrosis in Chinese NAFLD patients in our center. FIB-4 index performs better than the other tests under examination.

Cited by 38 publications

References 32 publications

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

Tissue Inhibitors of Metalloproteinase-1 and 2 and Obesity Related Non-Alcoholic Fatty Liver Disease: Is There a Relationship?

Association Between Urinary Alpha1-Microglobulin Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

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