Subpoblaciones linfocitarias de pacientes venezolanos infectados con SARS-CoV-2

Mayora, Soriuska; Lanz, Marcel; Martinez, Wendi; Toro, Félix; Sanctis, Juan B. De; García, Alexis

doi:10.47307/gmc.2020.128.s1.8

Cited by 2 publications

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“…In a previous report [35], the roles of memory T cells and age were analyzed in adult patients infected with COVID. Younger individuals responded and maintained the amount of memory T cells compared to older individuals whose memory T cells decreased.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Infection in Venezuelan Pediatric Patients—A Single Center Prospective Observational Study

et al. 2023

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Several studies suggest that children infected with SARS-CoV-2 have fewer clinical manifestations than adults; when they develop symptoms, they rarely progress to severe disease. Different immunological theories have been proposed to explain this phenomenon. In September 2020, 16% of the active COVID-19 cases in Venezuela were children under 19 years. We conducted a cross-sectional study of pediatric patients’ immune response and clinical conditions with SARS-CoV-2 infection. The patients were admitted to the COVID-19 area of the emergency department of Dr José Manuel de los Ríos Children’s Hospital (2021–2022). The lymphocyte subpopulations were analyzed by flow cytometry, and IFNγ, IL-6, and IL-10 serum concentrations were quantified using commercial ELISA assays. The analysis was conducted on 72 patients aged one month to 18 years. The majority, 52.8%, had mild disease, and 30.6% of the patients were diagnosed with MIS-C. The main symptoms reported were fever, cough, and diarrhea. A correlation was found between IL-10 and IL-6 concentrations and age group, lymphocyte subpopulations and nutritional status and steroid use, and IL-6 concentrations and clinical severity. The results suggest a different immune response depending on age and nutritional status that should be considered for treating pediatric COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Infection in Venezuelan Pediatric Patients—A Single Center Prospective Observational Study

et al. 2023

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Coronavirus infection: An immunologists' perspective

et al. 2021

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Coronaviruses (CoVs) are a collection of enveloped viruses with non-segmented, positive-sense single-stranded RNA genomes with distinctive crown-like spikes that protrude from the capsid of helical symmetry. 1 They have a remarkably long RNA genome and a particular replication strategy. In this complex family, several members attack different species causing several diseases that can end up in death. In November 2002, in China, a severe acute respiratory syndrome coronavirus (SARS-CoV) was identified. It promptly spread to other countries. There were around 8000 confirmed cases, and the mortality rate was 9.6%. 2 Then, another member of the family, Middle East respiratory syndrome coronavirus (MERS-CoV), appeared in Saudi Arabia in 2012 and later emerged in South Korea in 2015. The confirmed cases of MERS-CoV exceeded 2000, with a mortality rate of ∼35%. 2 In 2019, another member of the family was identified, SARS-CoV-2. 3 The number of infected people and the mortality rate still grow continuously. Infected elderly individuals with comorbidities exhibit the worst outcomes. There are now several vaccines against SARS-CoV-2 approved for emergency use by the regulatory offices of different countries.The coronavirus genome is formed by 2 UTR sites, 5′ and 3′, the replicase, the spike (Spike), the envelope E (Envelope), the M (Membrane), the N (Nucleocapsid) and

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Subpoblaciones linfocitarias de pacientes venezolanos infectados con SARS-CoV-2

Cited by 2 publications

References 0 publications

SARS-CoV-2 Infection in Venezuelan Pediatric Patients—A Single Center Prospective Observational Study

SARS-CoV-2 Infection in Venezuelan Pediatric Patients—A Single Center Prospective Observational Study

Coronavirus infection: An immunologists' perspective

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