“…Studies with Yptb have uncovered a great deal of knowledge about the interactions that occur at the host-bacterial interface. Some examples of key findings with Yptb include the discovery of invasin, an adhesin that promotes entry into host cells (Isberg, Voorhis, & Falkow, 1987); novel findings with siderophores and iron acquisition systems within host tissues (Pieper et al, 2010;Schwiesow et al, 2018); elucidation of the structure and function of the type III secretion system (T3SS) and its associated effector proteins and the impact of these effector proteins on the host cell cytoplasm and signaling pathways (Peterson et al, 2017;Rolán, Durand, & Mecsas, 2013;Schesser et al, 1998;Songsungthong, Higgins, Rolán, Murphy, & Mecsas, 2010;Spinner et al, 2010;Zhang & Bliska, 2010); definition of key events in the evolution of pathogens through genetic comparisons between Yptb and Y. pestis (Achtman et al, 1999;Chain et al, 2004); definition of the extent of heterogeneity within bacterial populations replicating in host tissues and identification of examples of cooperative behavior (Davis et al, 2015;Nuss et al, 2016;Raneses, Ellison, Liu, & Davis, 2020); determination of the role of dendritic cells and monocytes in promoting adaptive immune responses within intestinal tissues and the long-term impact on protective memory responses within white adipose tissue (Han et al, 2017;Zhang, Khairallah, Sheridan, van der Velden, & Bliska, 2018;Zhang, Mena, Romanov, & Bliska, 2014); and findings from the aforementioned studies of temperature-dependent regulation of virulence factor expression (Herbst et al, 2009;Nuss et al, 2016;Portnoy, Moseley, & Falkow, 1981).…”