Subretinal pigment epithelial infiltrates in primary vitreoretinal lymphoma

Vasconcelos-Santos, Daniel Vítor; Souza, Gustavo Henrique De Puy e; Faria, Bernardo Bacelar de; Pedrosa, Moisés Salgado; Diniz, André Vasconcellos; Oréfice, Juliana Lambert; Costa, Rogério A.; Oréfice, Fernando

doi:10.1007/s12348-011-0034-x

Cited by 9 publications

(11 citation statements)

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“…This would appear to correlate with localised proliferation of lymphoma cells and is in contrast to the more destructive changes observed in conditions associated with choroidal neovascularisation, where vascular proliferation occurs across the RPE. Furthermore, sub-RPE deposits on SD-OCT similar to those demonstrated in figure 4 have previously been shown to correspond to collections of diffuse large B-cell lymphoma cells on histopathology and immunohistochemical analysis 14. We speculate that the hyper-reflective foci in the posterior vitreous represent inflammatory aggregates in the vitreous gel.…”

Section: Discussionsupporting

confidence: 66%

Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis

et al. 2018

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We have identified a range of SD-OCT features, which we believe to be consistent with a diagnosis of PVRL. We propose that the observation of hyper-reflective subretinal infiltrates as described is highly suggestive of PVRL. This case series further demonstrates the utility of SD-OCT as a non-invasive and rapid aid to diagnosis, which may improve both visual outcomes and survival of patients with intraocular malignancies such as PVRL.

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Section: Discussionsupporting

confidence: 66%

Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis

et al. 2018

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“…Imaging features that suggest primary vitreoretinal lymphoma include OCT demonstrating sub-RPE or intraretinal infiltration of lymphoma, [35][36][37] as well as FA changes along a spectrum depending on tumor level and consisting of granularity, blockage, or late staining at the RPE level, or early and late hypofluorescent lesions in those with outer retinal infiltration. 38 With these imaging modalities, [35][36][37][38][39][40] it is noted that subretinal infiltration with primary vitreoretinal lymphoma is rare and not a prominent feature of this condition.…”

Section: We Present 3 Unique Cases Of Unilateral Transientmentioning

confidence: 99%

“…38 With these imaging modalities, [35][36][37][38][39][40] it is noted that subretinal infiltration with primary vitreoretinal lymphoma is rare and not a prominent feature of this condition. In our cases of cloudy vitelliform submaculopathy, we suspect a paraneoplastic process because it was subretinal in location, was transient, and resolved relatively quickly in all 3 cases.…”

Section: We Present 3 Unique Cases Of Unilateral Transientmentioning

confidence: 99%

Paraneoplastic Cloudy Vitelliform Submaculopathy in Primary Vitreoretinal Lymphoma

Pang

Shields

Jumper

et al. 2014

American Journal of Ophthalmology

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“…The deposits may represent lymphoma cells as those demonstrated in murine model [ 16 ]. Vasconcelos-Santos et al also identified clusters of lymphoma cells on chorioretinal biopsy of a patient who had large sub-RPE deposits [ 17 ]. Similarly, vitreous debris more commonly seen in eyes with lymphoma may also represent clusters of lymphoma cells along with the associated inflammatory cells [ 16 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating optical coherence tomography (OCT) findings as potential biomarkers in central nervous system (CNS) lymphoma with or without ocular involvement

Hassan

Halim

Afridi³

et al. 2021

Int J Retin Vitr

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Background To evaluate spectral domain optical coherence tomography (SD-OCT) findings as biomarkers in primary central nervous system lymphoma (PCNSL) with or without ocular involvement. Methods This study was a cross-sectional study and patients with a confirmed diagnosis of PCNSL with or without ocular involvement were included. Patient cohort finder tool was used to identify patients with lymphoma using ICD-10 codes (C82–C88), from January 2004 to October 2017. A total of 14,820 patients were identified. Procedure code (92134) for optical coherence tomography (OCT) was then applied to identify patients who had underdone OCT imaging at ophthalmology clinic. Clinic charts of 460 patients with lymphoma and available OCT were reviewed to identify patients with confirmed diagnosis of PCNSL and divided into two groups (Group 1: with and Group 2: without ocular involvement). OCT scans of patients in both study groups were analyzed for the presence of (1) Hyperreflective deposits in choroid, retinal pigment epithelium (RPE), outer and inner retina; (2) RPE thickening; (3) Vitreous debris; (4) Intraretinal fluid; (5) Ellipsoid zone disruption by masked graders. Chi-square was used to analyze the difference between the groups. Results Twenty-two eyes (11 patients) with PCNSL were included this study (Group 1: 6 eyes and Group 2: 16 eyes). Mean age of subjects was 65 years. Five patients (45.45%) were female. There was no statistically significant difference between the groups for the presence of hyperreflective deposits in choroid, RPE, outer and inner retina, and presence of RPE thickening, intraretinal fluid, and ellipsoid zone disruption. Vitreous debris was found more commonly in group 1 subjects (83%) than group 2 (31.25%) (p = 0.029). All subjects in both groups showed hyperreflective deposits in the RPE demonstrating RPE infiltration. However, RPE thickening was noted only in 3 patients (Group1: 1 and Group2: 2). Conclusions OCT finding of hyperreflective deposits present in eyes with lymphoma secondary to PCNSL are also observed in eyes with PCNSL without ocular disease. However, the vitreous deposits are more commonly found in eyes with ocular disease. These hyperreflective deposits can serve as biomarkers for early detection of ocular involvement by PCNSL.

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Subretinal pigment epithelial infiltrates in primary vitreoretinal lymphoma

Cited by 9 publications

References 0 publications

Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis

Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis

Paraneoplastic Cloudy Vitelliform Submaculopathy in Primary Vitreoretinal Lymphoma

Evaluating optical coherence tomography (OCT) findings as potential biomarkers in central nervous system (CNS) lymphoma with or without ocular involvement

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