Subselective measurement of coronary blood flow velocity using a steerable doppler catheter

Sibley, David H.; Millar, Huntly; Hartley, Craig J.; Whitlow, Patrick L.

doi:10.1016/s0735-1097(86)80305-9

Cited by 182 publications

(37 citation statements)

References 16 publications

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“…The use of this device to assess intracoronary blood flow velocity has been described in detail. 13 orthogonal views with the use of a power injection of nonionic contrast medium (Omnipaque, WinthropBreon, New York). Throughout each infusion, the heart rate, arterial pressure, coronary flow velocity, and electrocardiogram (lead I) were monitored continuously, and all measurements were recorded in steady-state conditions.…”

Section: Methodsmentioning

confidence: 99%

“…This particular system has been validated in animal experiments. 13 The advantages of this system are that it provides instantaneous and continuous measurement of phasic flow velocity and allows measurement well beyond the left main coronary artery without significantly restricting maximal blood flow. 26 The estimation of volume blood flow in this study is affected by coronary artery cross-sectional area, and we therefore adjusted the flow velocities for changes in cross-sectional area at the site of the Doppler sample volume to provide an index of volume flow.17 This study was not concerned with single absolute measures of volume blood flow but was concerned with serial changes using each patient as his own control.…”

Section: Flow-mediated Dilation Of Epicardial Coronary Arteriesmentioning

confidence: 99%

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Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.

et al. 1989

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Studies in animals have suggested that increases in blood flow result in dilation of large arteries by an endothelium-dependent mechanism. Atherosclerosis can impair endothelium-dependent vasodilation to vasoactive agents. The purpose of this study was to determine whether or not large coronary arteries in humans exhibit dilation with increases in blood flow and to test the hypothesis that this response is impaired in the presence of atherosclerosis. Graded concentrations of adenosine were infused into the distal left anterior descending (LAD) coronary artery to test the dilator response of the proximal LAD to increases in blood flow. The proximal LAD was thereby exposed to changes in blood flow, but not directly to adenosine. Ten patients with angiographically smooth proximal LAD segments (group 1) and seven patients with irregularities in the proximal LAD consistent with mild atherosclerosis (group 2) were studied. Infusions of adenosine throughout the range of 0.022 to 2.2 mg/min into the LAD produced a dose-dependent increase in estimated coronary blood flow and a mean increase of 305 ±27% at 2.2 mg/min adenosine. At 2.2 mg/min adenosine, a striking dilference (p<0.001) occurred between the significant flow-mediated dilation of the proximal LAD observed in group 1 (+13.2±1.3% from 2.63±0.16 mm,p<0.001), and the lack of dilation in group 2 (+1.8±1.5% from 3.20±0.17 mm, p=NS), despite a greater increase in coronary blood flow in group 2 (+387±29%) than in group 1 (+230±36%). When adjacent segments of the same arteries in these patients were directly exposed to an infusion of the endothelium-independent vasodilator nitroglycerin (16.6 ug/min), angiographically smooth and irregular segments dilated similarly (+31.1+4.3% and +33.6±4.2%, respectively). Thus, in humans, flow-mediated dilation was observed in angiographically normal proximal LAD segments but was markedly impaired in atherosclerotic vessels. Because the normal and mildly atherosclerotic vessels were capable of equal dilation to the endothelium-independent vasodilator nitroglycerin, the absence of flow-mediated dilation in atherosclerosis may reflect impaired endothelial vasodilator function. (Circulation 1989;80:458-465

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Section: Methodsmentioning

confidence: 99%

Section: Flow-mediated Dilation Of Epicardial Coronary Arteriesmentioning

confidence: 99%

Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.

et al. 1989

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“…Changes in coronary blood flow in response to drug infusions were determined from changes in mean coronary blood velocity corrected for alterations in cross-sectional area at the Doppler catheter tip. The limitations of the Doppler catheter preclude direct determination of coronary blood flow (18,32).…”

Section: Nitric Oxide Adducts With Serum Albumin 1583mentioning

confidence: 99%

NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.

Keaney¹,

Simon²,

Stamler³

et al. 1993

J. Clin. Invest.

280

143

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“…Thus, measurements of coronary flow or velocity have required the use of invasive methods such as implantable flow probes (Hartley and Cole, 1974) or coronary catheters (Cole and Hartley, 1977;Sibley et al, 1986;Wilson et al, 1985). In addition, coronary blood flow (even if it could be measured accurately) is often normal at rest even in the presence of severe coronary artery disease (Gould et al, 1974;Marcus et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Effects of Isoflurane on Coronary Blood Flow Velocity in Young, Old and ApoE−/− Mice Measured by Doppler Ultrasound

Hartley

Reddy

Madala

et al. 2007

Ultrasound in Medicine & Biology

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The commonly used anesthetic agent, isoflurane (ISO), is a potent coronary vasodilator which could potentially be used in the assessment of coronary reserve, but its effects on coronary blood flow in mice are unknown. Coronary reserve is reduced by age, coronary artery disease, and other cardiac pathologies in man, and some of these conditions can now be modeled in mice. Accordingly, we used Doppler ultrasound to measure coronary flow velocity in mice anesthetized at low (1%) and at high (2.5%) levels of ISO to generate baseline (B) and elevated hyperemic (H) and Y and between A and O were significant (P < 0.01), while the differences in hyperemic velocities were not (P > 0.05). H/B was higher in old mice due to decreased baseline flow rather than increased hyperemic flow velocity. In contrast ApoE −/− mice have increased baseline and hyperemic velocities perhaps due to coronary lesions. The differences in baseline velocities between young and old mice could be due to age-related changes in basal metabolism or to differential sensitivity to isoflurane. We conclude that Doppler ultrasound combined with coronary vasodilation via isoflurane could provide a convenient and noninvasive method to estimate coronary reserve in mice, but also that care must be taken when assessing coronary flow in mice under isoflurane anesthesia because of its potent coronary vasodilator properties.

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Subselective measurement of coronary blood flow velocity using a steerable doppler catheter

Cited by 182 publications

References 16 publications

Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.

Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.

NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.

Effects of Isoflurane on Coronary Blood Flow Velocity in Young, Old and ApoE−/− Mice Measured by Doppler Ultrasound

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