Subsensitivity of beta responses during therapy with a long-acting beta-2 preparation

Jenne, John W.; Chick, Thomas W.; Strickland, Richard D.; Wall, Francis J.

doi:10.1016/0091-6749(77)90023-9

Cited by 120 publications

(25 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, no general conclusions regarding The two last-mentioned studies (45,47) indibasal cAMP concentration and rise in cAMP cate that some degree of P resistance in the concentration following P stimulation in asth-airway develops following long-term oral or inmatics can be drawn.…”

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

“…adrenergic resistance develops gradually over 4) The patient populations studied show 9-10 days. great differences with respect to general disExamining both asthmatics and chronic bronease severity, actual disease activity and drug chitics, Jenne (47) found that continuous terbuuse (34,49,67,68,73). Often data regarding taline therapy (5 mg three times daily) causes a one or several of these factors are lacking.…”

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

“…Following oral terbu-P stimulators, especially P2 stimulators, are taline therapy (5 mg three times a day) the widely used in the treatment of asthma, both as developed bronchial subsensitivity is very slight tablets and as inhalators. The question whether and may be obscured by elevated baseline values long-term use of P adrenergic drugs induces of FEVj (47). Jenne mentions (47) that the basedesensitization to further P stimulation has na-line values of FEVj before isoproterenol inturally been raised.…”

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

“…During normal continuous therapy this seems to be of no clinical importance (47,89). It may be speculated that this P subsensitivity may assume importance, when inhalations are added to the oral treatment and/or the P agonists are used in great excess (45,47), but this has in fact not been demonstrated to date.…”

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

“…It may be added that one of the beneficial effects of corticosteroids in the treatment of severe asthma is that these drugs restore the P sensitivity in the airways to normal values (47,85).…”

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

See 4 more Smart Citations

Adrenoceptors: Molecular Nature and Role in Atopic Diseases

Djurup

1981

Allergy

View full text Add to dashboard Cite

Since Szentivanyi proposed the idea that asthma and other atopic ditseases are due to a P adrenergic defect there has been much interest in the role of the adrenergic receptors in allergy. The radioactive ligand binding techniques developed within the last few years have greatly increased our knowledge concerning the molecular nature of the adrenoceptors and the events following receptor sdmulation. The adrenoceptors have shown to be very dynamic structures. Their number and affinity may be altered due to various physiological and pharmacological stimuli. Their role in the pathogenesis of atopic diseases has not been definitely settled, but there seem to be a true beta adrenergic hyporesponsiveness and alpha hyperresponsiveness in asthma. This article briefly describes the radioligand binding technique and summarizes our present knowledge of the nature of the alpha and beta adrenoceptors and their possible role in atopic diseases.Key words: adrenergic receptors; atopy; asthma. Accepted fcyr publication 11 January 1981, , , rr 1 , ^^ 01 receptor is defmed as a receptor for Functional subclassification of the adrenoceptorswhich epmephrme is a more potent stimulator It has been known since the beginning of the (agonist) than norepinephrine which again is century that the sympathomimetic amines have more potent than isoproterenol. The potency both excitatory and inhibitory effects in the of the amines was examined in intact animals organism. Early investigators proposed the or isolated organ preparations. In contrast, the existence of two fundamental types of mediator P receptor is defined as a receptor for which substances: an excitatory sympathin E and an isoproterenol is a more potent agonist than inhibitory sympathin I (1). As no amine which epinephrine which again is more potent than fulfilled the requirements for either sympathin norepinephrine. The development of relatively E or I could be found, the idea of two different selective a and |3 antagonists has further conreceptor types emerged. On the basis of the firmed the pharmacological usefulness of the a relative potency of six adrenergic amines on and P receptor concept. Table 1 summarizes various biological (mainly haemodynamic) pa-the major pharmacological characteristics of rameters, Ahlquist (1) defined two different the a and the j3 receptor. receptors: an a receptor which mediates most In 1967, Lands (55) showed that there is of the adrenergic amines' excitatory functions marked similarity between the relative poten-(vasoconstriction, pupil dilation, uterine con-cies of sympathomimetic amines on lipolysis traction) and a few inhibitory (intestinal relax-and cardiac stimulation on the one hand and ation), and a P receptor which mediates most of on bronchodilation and vasodepression on the the inhibitory functions (vasodilation, broncho-other. Furthermore, a potent lipolytic and cardilation, uterine relaxation) and a few excita-diac stimulating amine is a poor bronchodilator tory (cardiac inotropy and chronotropy).and vasodepressor. Therefore, Lands s...

show abstract

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

Section: ) the Basal Camp Concentration And Thementioning

confidence: 99%

See 3 more Smart Citations

Adrenoceptors: Molecular Nature and Role in Atopic Diseases

Djurup

1981

Allergy

View full text Add to dashboard Cite

show abstract

Clinical aerosols II. Therapeutic aerosols

Lourenço¹

1982

Archives of Internal Medicine

View full text Add to dashboard Cite

The current uses of clinical aerosols such as water, saline, mucolytics, bronchodilators, cromolyn sodium, corticosteroids, and antimicrobials have been reviewed. The benefits of water, saline, and detergent aerosols continue to be surrounded by uncertainty and controversy. Aerosolized mucolytic and proteolytic agents have not been conclusively shown to be of substantial value in the improvement of respiratory disorders. Favorable bronchodilator therapy is achieved with aerosols of certain sympathomimetic and anticholinergic agents. However, successful therapy depends on the dose administered and the site of aerosol deposition in the lung. The prophylactic use of cromolyn sodium in patients with asthma is another useful application of aerosols. Topically active corticosteroid aerosols are increasingly being used since they may reduce risks of systemic effects from corticosteroids. Research on uncommonly aerosolized agents has widened the spectrum of therapeutic applications of aerosols.

show abstract