Subsequent Neoplasia in Chronic Lymphocytic Leukemia

Manusow, David; Weinerman, Brian

doi:10.1001/jama.1975.03250030023012

Cited by 158 publications

(93 citation statements)

References 11 publications

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“…The extensive cellular immune deficiency of B-CLL patients along with the clinical complications seen in CLL comprising an increased rate of bacterial infections and certain malignancies 20 makes the Guven et al findings reported here relevant and timely. While the bacterial infections in B-CLL could be linked to a simple deficiency in humoral immunity, B-CLL patients also have increasing problems with viral and fungal infections particularly as the disease progresses.…”

mentioning

confidence: 61%

Reconstitution of innate immunity in B-chronic lymphocytic leukemia: time to reconsider the possibilities

Lee

Kay

2003

Leukemia

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mentioning

confidence: 61%

Reconstitution of innate immunity in B-chronic lymphocytic leukemia: time to reconsider the possibilities

Lee

Kay

2003

Leukemia

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“…Approximately 10-20% of CLL/SLL patients develop second primary malignancies, which in two-thirds of the cases are the cause of their demise [11]. Head and neck neoplasms are common solid tumors occurring either synchronously or subsequently in CLL/SLL patients, possibly due to immune dysregulation [12][13][14]. A recent study showed high HPV prevalence in various second solid neoplasms in CLL patients [15], further supporting this hypothesis.…”

Section: Discussionmentioning

confidence: 85%

Small Lymphocytic Lymphoma Obscuring Microscopic Tonsillar Squamous Cell Carcinoma: an Unknown Occurrence with a Known Primary

Minca

Popat

Chadha³

et al. 2010

Head and Neck Pathol

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Head and neck squamous cell carcinoma (HNSCC) often presents with cervical lymph node metastases and at times the primary tumor cannot be identified despite extensive workup. Lymphoma is the second most common neoplasm in the head and neck region but is seldom synchronous with HNSCC and rarely involves regional mucosal sites. We report herein a rare occurrence of tonsillar involvement by small lymphocytic lymphoma (SLL) incidentally detected during the workup for a cervical lymph node SCC metastasis of a 52-year-old nonsmoker male. The microscopic human papillomaviruspositive SCC involving the tonsillar surface and crypts was obscured by SLL leading to the initial designation of 'unknown primary'. The occult HNSCC are likely explained by small tumor size, quality and quantity of sampling, thoroughness of endoscopic, radiological and pathological assessment or a combination of the above. The coexistence of another tumor such as lymphoma has not yet been reported as a confounding factor in the workup for cervical SCC metastasis. Since oropharyngeal SCC can be very small and Waldeyer's ring is a common site for lymphoma involvement, identification of such rare collision tumors requires pathologists' awareness, extensive sampling and occasionally ancillary studies for the accurate diagnosis and staging essential for the correct management.

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“…Chronic lymphocytic leukemia causes aberrant immune response and it is associated with frequent infections and appearance of secondary malignancies [1], and occasionally with MCC. Koljonen et al in the group of 4,164 patients with CLL and 172 patients with MCC found 6 patients had both malignancies [3].…”

Section: Discussionmentioning

confidence: 99%

“…This epidemiological phenomenon is explained by immunosuppression caused by disease itself or by the applied therapy [1]. Merkel cell carcinoma (MCC) is a rare malignant tumor of the skin of neuroendocrine origin.…”

Section: Introductionmentioning

confidence: 99%

Concurrent Chronic Lymphocytic Leukemia and Merkel Cell Carcinoma in Primary Skin Tumor and Metastatic Lymph Node

Popović

Jovanović

Petrović

et al. 2014

Indian J Hematol Blood Transfus

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Association between chronic lymphocytic leukemia and other malignancies has been known for a long time. This epidemiological phenomenon is explained by immunosuppression caused by disease itself or by the applied therapy. Merkel cell carcinoma is a rare malignant tumor of the skin of neuroendocrine origin diagnosed almost exclusively in immunocompromised host. We presented an unique case of coexisting infiltration of chronic lymphocytic leukemia cells within primary cutaneous Merkel cell carcinoma and metastatic lymph node in young HIV-negative female patient.

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Subsequent Neoplasia in Chronic Lymphocytic Leukemia

Cited by 158 publications

References 11 publications

Reconstitution of innate immunity in B-chronic lymphocytic leukemia: time to reconsider the possibilities

Reconstitution of innate immunity in B-chronic lymphocytic leukemia: time to reconsider the possibilities

Small Lymphocytic Lymphoma Obscuring Microscopic Tonsillar Squamous Cell Carcinoma: an Unknown Occurrence with a Known Primary

Concurrent Chronic Lymphocytic Leukemia and Merkel Cell Carcinoma in Primary Skin Tumor and Metastatic Lymph Node

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