Subsequent primary cancers after basal-cell carcinoma: A nationwide study in Finland from 1953 to 1995

Milán, T.; Pukkala, Eero; Verkasalo, Pia K.; Kaprio, Jaakko; Jansén, Christer T.; Koskenvuo, Markku; Teppo, Lyly

doi:10.1002/1097-0215(20000715)87:2<283::aid-ijc21>3.0.co;2-i

Cited by 73 publications

(70 citation statements)

References 25 publications

(30 reference statements)

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“…These have shown a consistent link between SCC and melanoma, while an association between skin and eye cancer has been noted (Milan et al, 2000). Many studies on second cancers have found an excess of cancers associated with immunological disturbances and immunosuppression, including lymphoma, and lip (oral), cervical and connective tissue cancers (IARC, 1996).…”

Section: Discussionmentioning

confidence: 95%

“…In contrast to the scarcity of familial data on skin SCC, there are many studies published on second cancers following skin SCC (Frisch and Melbye, 1995;Levi et al, 1996Levi et al, , 1997Levi et al, , 1998Wassberg et al, 1999;Dong and Hemminki, 2001b;Hemminki and Dong, 2000b, c;Milan et al, 2000). These have shown a consistent link between SCC and melanoma, while an association between skin and eye cancer has been noted (Milan et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

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Familial invasive and in situ squamous cell carcinoma of the skin

2003

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We used the updated nation-wide Swedish Family-Cancer Database to examine familial risks in data from 1961 to 1998 on 1252 invasive and 2474 in situ squamous cell carcinoma (SCC) of the skin among offspring, and over 10 times more among parents. In 259 families a parent and an offspring had skin SCC. The familial standardised incidence ratios (SIRs) were 2.72 for invasive and 2.40 for in situ skin cancers in offspring. Multiple skin cancers in parents were associated with increased SIRs for invasive SCC in offspring, being 2.55 for one and up to 14.93 for two invasive and two in situ cancers in parents; the corresponding in situ SCC risks were 2.28 and 7.49. The population attributable fraction for any familial skin SCC, invasive or in situ, was 4.1%. Melanoma was the only discordant tumour that was associated with invasive and in situ skin SCC. These results provide evidence that there is an underlying hereditary susceptibility for at least a part of the familial clustering for skin SCC. Squamous cell carcinoma (SCC) of the skin is not recorded by most cancer registries and its established risk factors are limited to fair skin, ultraviolet light, arsenic compounds and immunosuppression, while less is known about benign lesions, such as actinic keratosis and in situ carcinoma (intraepidermal SCC, or Bowen's disease) (IARC, 1990(IARC, , 1995English et al, 1997) The Swedish Cancer Registry has recorded both invasive and in situ SCC whose incidence has rapidly increased over the past 20 years (Center for Epidemiology, 2000;Wassberg et al, 2001). Skin SCC is the fourth most common cancer in men and women in Sweden in 1998, and the in situ form is the most common benign/precancerous tumour in men and the second among women after in situ cervical cancer. In situ skin cancer does not appear to be a simple precursor lesion to invasive SCC because the age of onset of the two forms is similar; a true precursor lesion would be expected to show an earlier age of onset, as with cervical in situ and invasive cancers

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Familial invasive and in situ squamous cell carcinoma of the skin

2003

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“…9 -13 The exception has been a Finnish study that reported an increase in unspecified eye cancer after basal cell skin cancer, another UVR-related tumor. 14 As some 80% of eye neoplasms are melanomas, the association was likely to be to OM, although no comment was made by the authors. The coexistence of OM and CM in some patients has suggested a predisposition to both types.…”

Section: Dear Sirmentioning

confidence: 99%

Association of first ocular melanoma with subsequent cutaneous melanoma: Results from the Swedish Family‐Cancer Database

Hemminki

Zhang

Czene

2003

Intl Journal of Cancer

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“…This possibility is consistent with the lack of a significant overall risk of eye cancer following a basal cell carcinoma (BCC) (SIR 1.46, 95% CI 0.96 -2.12) in data of the Finnish Cancer Registry, but when the calculation was restricted to BCC of the site with substantial relevant sun exposure (the head and neck), the estimate was significant (SIR 1.76, 95% CI 1.14 -2.59). 5 Yours sincerely, Anne KRICKER, Claire VAJDIC and Bruce ARMSTRONG…”

Section: Dear Sirmentioning

confidence: 98%

Ocular melanoma and cutaneous melanoma

Kricker

Vajdic

Armstrong

2003

Intl Journal of Cancer

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Dear Sir,We welcome the data of Hemminki et al. 1 from the Swedish Family-Cancer Database that show an association between cutaneous and ocular melanoma although only when cutaneous melanoma (CM) follows an ocular melanoma (CM) (SIR 4.01, 95% CI 2.24 -6.62) and not the reverse (SIR 0.87, 95% CI 0.16 -2.57). These associations are consistent with those reported by Shors et al. 2 in U.S. Surveillance, Epidemiology and End Results (SEER) data. The lack of an increased risk of OM after CM, however, in these 2 studies is based on only 10 OMs, and a summary SIR calculated from these 2 studies, 1.2 with 95% CI 0.6 -2.6, is compatible with the significant increase in risk of OM in people who gave a prior history of CM (summary OR over all OM categories 2.1 (1.2-3.5) in our Australian case-control study. 3 Our study, as Hemminki et al. 1 state, also produced strong evidence that sun exposure was positively associated with choroid and ciliary body melanoma, the most common site of ocular melanoma, and was most persuasive for occupational sun exposure and in the first 20 years of life, especially in men. 3

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Subsequent primary cancers after basal-cell carcinoma: A nationwide study in Finland from 1953 to 1995

Cited by 73 publications

References 25 publications

Familial invasive and in situ squamous cell carcinoma of the skin

Familial invasive and in situ squamous cell carcinoma of the skin

Association of first ocular melanoma with subsequent cutaneous melanoma: Results from the Swedish Family‐Cancer Database

Ocular melanoma and cutaneous melanoma

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