Subsequent Skin Cancers in Kidney and Heart Transplant Recipients after the First Squamous Cell Carcinoma

Euvrard, Sylvie; Kanitakis, Jean; Decullier, Évelyne; Butnaru, Agripina Cristina; Lefrançois, N; Boissonnat, P.; Sebbag, Laurent; Garnier, J. L.; Pouteil‐Noble, Claire; Cahen, R; Morélon, Emmanuel; Touraine, Jean‐Louis; Claudy, A; Chapuis, François

doi:10.1097/01.tp.0000209921.60305.d9

Cited by 161 publications

(157 citation statements)

References 38 publications

(48 reference statements)

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“…9 Age at transplantation and duration and dosage of immunosuppression are major determinants of SCC development. 10,11 Furthermore, dosage of immunosuppression is a major determinant of the risk for SCC metastasis, which has an incidence of 1 to 4%. 9,12 The median survival after a diagnosis of poor-prognosis SCC is approximately 2 years.…”

mentioning

confidence: 99%

Immune Phenotype Predicts Risk for Posttransplantation Squamous Cell Carcinoma

Carroll

Segundo²,

Hollowood³

et al. 2010

Journal of the American Society of Nephrology

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Cutaneous squamous cell cancer (SCC) affects up to 30% of kidney transplant recipients (KTRs) within 10 years of transplantation. There are no reliable clinical tests that predict those who will develop multiple skin cancers. High numbers of regulatory T cells associate with poor prognosis for patients with cancer in the general population, suggesting their potential as a predictive marker of cutaneous SCC in KTRs. We matched KTRs with (n ϭ 65) and without (n ϭ 51) cutaneous SCC for gender, age, and duration of immunosuppression and assessed several risk factors for incident SCC during a median follow-up of 340 days. Greater than 35 peripheral FOXP3 ϩ CD4 ϩ CD127 low regulatory T cells/l, Ͻ100 natural killer cells/l, and previous SCC each significantly associated with increased risk for new cutaneous SCC development (hazard ratio [HR] 2.48 [95% confidence interval (CI) 1.04 to 5.98], HR 5.6 [95% CI 1.31 to 24], and HR 1.33 [95% CI 1.15 to 1.53], respectively). In addition, the ratio of CD8/FOXP3 expression was significantly lower in cutaneous SCC excised from KTRs (n ϭ 25) compared with matched SCC from non-KTRs (n ϭ 25) and associated with development of new cutaneous SCCs. In summary, monitoring components of the immune system can predict development of cutaneous SCC among KTRs.

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confidence: 99%

Immune Phenotype Predicts Risk for Posttransplantation Squamous Cell Carcinoma

Carroll

Segundo²,

Hollowood³

et al. 2010

Journal of the American Society of Nephrology

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“…16 In addition, habitual use of sunscreens and other photoprotection decreased the rate of subsequent SCCs after a first SCC in OTRs. 17 UV protection is therefore essential for both primary [10][11][12] and secondary prevention of NMSC, and this behaviour should be reinforced in healthy patients as well as in OTRs and others at elevated risk of skin cancer.…”

Section: "I Rarely Bother With Sunscreen"mentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 2: Primary Prevention of Non-melanoma Skin Cancer

Barber

Searles

Vender³

et al. 2015

J Cutan Med Surg

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Background: Non-melanoma skin cancer (NMSC), including basal and squamous cell carcinoma (BCC and SCC), represents the most common malignancy. Objective: To provide guidance to Canadian health care practitioners regarding primary prevention of NMSC. Methods: Structured literature searches were conducted, using search terms including prevention, sunscreen, and sun prevention factor. All recommendations concern guidance that physicians should regularly discuss with their patients to help establish photoprotection habits. The GRADE system was used to assign strength to each recommendation. Results: Ultraviolet exposure is the major modifiable risk factor for NMSC. Aspects of photoprotection, including effective sunscreen use and avoidance of both the midday sun and artificial tanning, are discussed. Several widespread misunderstandings that undermine responsible public health measures related to sun safety are addressed. Conclusions: Photoprotection represents both an individual priority and a public health imperative. By providing accurate information during routine patient visits, physicians reinforce the need for ongoing skin cancer prevention. RésuméContexte : De tous les cancers, le carcinome cutané (non-mélanome), y compris le carcinome basocellulaire et le carcinome spinocellulaire, est le plus fréquent. Objectif : Fournir des conseils aux professionnels canadiens de la santé au sujet de la prévention du carcinome cutané. Méthodologie : On a effectué des recherches documentaires structurées à l'aide de divers mots clés, dont « prévention », « écran solaire » et « facteur de protection solaire ». Toutes les recommandations que nous avons repérées portent sur des conseils dont les médecins devraient régulièrement discuter avec leurs patients pour les aider à adopter des habitudes de photoprotection. On a utilisé l'échelle GRADE pour évaluer la pertinence de chacune des recommandations. Résultats : L'exposition aux rayons UV est le plus important facteur de risque modifiable du carcinome cutané. Certains aspects de la photoprotection, entre autres l'utilisation efficace d'un écran solaire, l'évitement du soleil de mi-journée et l'évitement du bronzage artificiel, sont examinés. Plusieurs croyances erronées répandues nuisent aux mesures de santé publique en matière de protection contre le soleil. Conclusions : La photoprotection constitue autant une priorité personnelle qu'un impératif de santé publique. En fournissant des renseignements précis aux patients lors des visites de routine, les médecins insistent sur la nécessité d'une prévention continue du cancer de la peau.

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“…Sun exposure is an important risk factor for multiple lesions development. Fair skin of patients and light color of the hair and the eyes are predictive of multiple SCC development (Euvrard et al, 2006). Male sex is also a risk factor for multiple skin cancer development, especially the BCC.…”

Section: Multiple Independent Primary Cancers or Second Tumor In Tranmentioning

confidence: 99%

Malignant Neoplasms in Kidney Transplantation

Sheikh¹,

Amir²,

Amir³

2012

Renal Transplantation - Updates and Advances

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Subsequent Skin Cancers in Kidney and Heart Transplant Recipients after the First Squamous Cell Carcinoma

Abstract: Although the proportion of HTR developing new tumors is greater as compared with KTR, the mean number of tumors per patient is higher in KTR. This could be due to a longer immunosuppression in patients younger at transplantation.

Cited by 161 publications

References 38 publications

Immune Phenotype Predicts Risk for Posttransplantation Squamous Cell Carcinoma

Immune Phenotype Predicts Risk for Posttransplantation Squamous Cell Carcinoma

Non-melanoma Skin Cancer in Canada Chapter 2: Primary Prevention of Non-melanoma Skin Cancer

Malignant Neoplasms in Kidney Transplantation

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