Substance abuse and gender differences in first episode psychosis: Impact on hospital readmissions

Crosas, Josep; Cobo, Jesús; Ahuir, Maribel; Hernández, Carla; García, Rebeca Robles; Pousa, Esther; Oliva, Joan-Carles; Monreal, José-Antonio; Palao, Diego

doi:10.1016/j.rpsmen.2018.02.003

Cited by 2 publications

(4 citation statements)

References 27 publications

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“…In general, female patients tend to debut with FEP at older ages than men [ 2 , 4 , 5 ]. In terms of clinical presentation, women tend to present more anxiety and affective symptoms, and parasuicidal behavior; by contrast, male patients tend to present more disorganization and negative symptoms, including social withdrawal, emotional blunting, and amotivation, although the reported findings are not always consistent among studies [ 9 , 57 ] .…”

Section: First-episode Psychosismentioning

confidence: 99%

“…In patients with FEP, SUD comorbidity is associated with poor clinical outcomes, including more severe psychopathology, more positive symptoms and dissociation symptoms, and higher relapse rates [ 5 , 60 - 63 ]. Substance use may also be associated with specific distinctive symptoms in FEP, such as depersonalization, derealization and visual or cenestethic hallucinations, as has been described in substance exogenous psychosis [ 64 ].…”

Section: First-episode Psychosismentioning

confidence: 99%

“…Cannabis use disorder is the most common substance use disorder in FEP [ 73 ]. However, cannabis use is less common in female patients with FEP [ 5 , 74 - 76 ]. While almost 70% of men with FEP smoke cannabis, the corresponding percentage in women is around 28-36% [ 4 , 58 , 59 ].…”

Section: First-episode Psychosismentioning

confidence: 99%

“…Despite the importance of gender perspectives in psychosis, most research conducted to date on psychosis and comorbid substance use has not specifically investigated the role of gender. Gender has been mostly studied as a covariate in the analyses, but not as the central hypothesis of the study [ 4 , 5 ]. However, more recent studies have specifically focused on gender differences [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Substance use Specificities in Women with Psychosis: A Critical Review

Casanovas

Fonseca

Mané

2023

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Background: Women with schizophrenia or other psychotic disorders differ from male patients in many respects, including psychopathology, prognosis, disease course, and substance use comorbidities. Most studies performed to date to investigate the association between drug use and psychosis have not evaluated gender differences, although this has started to change in recent years. Methods: We briefly summarize the available evidence on gender differences in drug use and substance use disorders (SUD) in psychotic patients during the early phases of the psychotic illness and during the course of schizophrenia. Results: Substance use and SUD are both less prevalent in women, both in the general population and at all phases of the psychotic spectrum. Some studies suggest that SUD may be underdiagnosed in female patients, in part due to their more vulnerable profile. Substance use, especially cannabis, may more negatively impact females, especially on the disease course and prognosis. The available data suggest that it may be more difficult to treat SUD in female patients with schizophrenia, which could negatively impact prognosis. Conclusion: Women with concomitant psychotic illness and SUD comprise a highly vulnerable subgroup. This should be considered when selecting the treatment approach, especially in the early phases of the illness, to ensure better outcomes.

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