The concurrent and predictive validity of 2 different methods of Millon Clinical Multiaxial Inventory-III subtyping (protocol sorting, cluster analysis) was evaluated in 125 recently detoxified opioid-dependent outpatients in a 12-week randomized clinical trial. Participants received naltrexone and relapse prevention group counseling and were assigned to 1 of 3 intervention conditions: (a) no-incentive vouchers, (b) incentive vouchers alone, or (c) incentive vouchers plus relationship counseling. Affective disturbance was the most common Axis I protocol-sorted subtype (66%), antisocial-narcissistic was the most common Axis II subtype (46%), and cluster analysis suggested that a 2-cluster solution (high vs. low psychiatric severity) was optimal. Predictive validity analyses indicated less symptom improvement for the higher problem subtypes, and patient treatment matching analyses indicated that some subtypes had better outcomes in the no-incentive voucher conditions. Addiction subtyping research has identified constellations of personality dimensions (Barnes, Murray, Patton, Bentler, & Anderson, 2000) and psychiatric disorders (Kranzler & Rounsaville, 1998) that are associated with the onset and severity of substance abuse and may have relevance for predicting treatment response. The presence of co-occurring psychiatric disorders seems to indicate a need for specialized or more intensive addiction treatment, and depression, antisocial personality, and general psychiatric symptom severity have been the most commonly investigated problems. Depressed cocaine abusers benefit from cognitive-behavioral coping skills and pharmacotherapy (Carroll et al., 1994), and opiate abusers with greater psychiatric severity improve with more intensive psychosocial programs (McLellan et al., 1983). Antisocial alcohol abusers seem to have better outcomes with coping skills than with interactional approaches (Kadden, Cooney, Getter, & Litt, 1989;Longabaugh et al., 1994), although Kadden, Litt, Cooney, Kabela, and Getter (2001) failed to replicate this effect. Antisocial methadone patients do as well as (Brooner, Kidorf, King, & Stoller, 1998;Silverman et al., 1998), and perhaps better than (Messina, Farabee, & Rawson, 2003), non-antisocial patients when provided with potent behavioral incentives, individual psychotherapy (Woody, McLellan, Luborsky, & O'Brien, 1985), or enhanced psychosocial services (Cacciola, Alterman, & Rutherford, 1995;Cacciola, Rutherford, Alterman, McKay, & Snider, 1996). The current study evaluated psychopathology subtypes derived from the Millon Clinical Multiaxial Inventory-III (MCMI-III;Millon, 1994), the most recent edition of a widely used instrument that measures Axis I and II diagnoses of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; American Psychiatric Association, 1994) and is also rooted in a biopsychosocial personality theory that may be relevant to the treatments compared in this study.
MCMI Psychopathology Subtyping ProceduresThe ability to prospe...