Substance misuse in early pregnancy and relationship to fetal outcome

Sherwood, Roy; Keating, James W.; Kavvadia, V; Greenough, Anne; Peters, Timothy J.

doi:10.1007/s004310051126

Cited by 93 publications

(48 citation statements)

References 23 publications

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“…Anonymous screening of consecutive urine samples testing positive for pregnancy in a UK inner city demonstrated that approximately 16% of the women were taking illicit drugs [19]. Unfortunately, infants of mothers who abuse opiates antenatally may develop neonatal abstinence syndrome (NAS) and require prolonged treatment and neonatal unit admission.…”

Section: Introductionmentioning

confidence: 99%

Neonatal abstinence syndrome—postnatal ward versus neonatal unit management

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Neonatal abstinence syndrome—postnatal ward versus neonatal unit management

et al. 2009

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“…Previous research linking antenatal cannabis use and adverse pregnancy outcomes has been inconclusive (5). A number of studies have reported some adverse effects, including low birth weight (6)(7)(8)(9), preterm birth (7,8,10), small for gestational age (SGA) (7), and small birth length (11,12). However, other studies have disputed these findings (10,(12)(13)(14)(15)(16)(17)(18).…”

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confidence: 99%

“…Limitations include small or highly selected samples (8,12); lack of prospectively collected measures of cannabis use; and lack of control for potential confounders, e.g., socioeconomic status and maternal health, and also use of other substances (cigarettes, alcohol, and other drugs) (7). Cannabis users differ from nonusers in a range of ways and any observed association with ever using cannabis may be indicative of residual or uncontrolled confounding.…”

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confidence: 99%

Birth outcomes associated with cannabis use before and during pregnancy

et al. 2011

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Articles Clinical Investigationnature publishing group INTRODUCTION:This study aimed to examine the association between cannabis use before and during pregnancy and birth outcomes. RESULTS: Overall, 26.3% of women reported previous use of cannabis and 2.6% reported current use. Multivariate analysis, controlling for potential confounders, including tobacco smoking, alcohol consumption, and use of other illicit drugs, showed that cannabis use in pregnancy was associated with low birth weight (odds ratio (OR) = 1.7; 95% confidence interval (cI): 1.3-2.2), preterm labor (OR = 1.5; 95% cI: 1.1-1.9), small for gestational age (OR = 2.2; 95% cI: 1.8-2.7), and admission to the neonatal intensive care unit (OR = 2.0; 95% cI: 1.7-2.4). DISCUSSION:The results of this study show that the use of cannabis in pregnancy is associated with increased risk of adverse birth outcomes. Prevention programs that address cannabis use during pregnancy are needed. METHODS: Data were from women birthing at the Mater Mothers' hospital in Brisbane, australia, over a 7-y period (2000)(2001)(2002)(2003)(2004)(2005)(2006). Women were interviewed in the initial antenatal visit about their use of cannabis and other substances. Records for 24,874 women who provided information about cannabis use, and for whom birth outcomes data were available, were included in the analysis.

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“…Special attention should be paid to signs of intrauterine growth retardation (IUGR), microcephaly, prematurity, congenital infection, and major and minor congenital malformations (12). Two of the infants were preterm, none of the infants was small for gestational age.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Abstinence Syndrome Due to Opioid Abuse in Pregnancy

Ozyurt¹,

Onay²,

Ersoy³

2018

Gynecol Obstet Reprod Med

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Opioid abuse during pregnancy is increasing in women of childbearing age in Turkey. The frequency of clinical signs of withdrawal in infants who exposed to heroin in utero are varying between 16-90%. Here, we present five newborn infants presenting with neonatal abstinence syndrome who were hospitalized in Neonatal Intensive Care Unit of Mersin Maternity and Children's Hospital. All of the five infants were symptomatic including irritability, tremors, high-pitched cry, excessive sucking and seizure. Hyperirritability was the predominant sign. Seizure was observed two of the five infants which clinically presented between 1 st -5 th day of life and was controlled with phenobarbital. We have experienced seizure due to withdrawal of opioid more than the past reports and we thought that interrupting breastfeeding may facilitate seizure. Breastfeeding may slow down the decrease of opioid level in blood and may reduce the symptoms. In conclusion, opioid abuse in pregnancy is a growing sociological problem in Turkey and a protocol for management is required for neonatologists.

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Substance misuse in early pregnancy and relationship to fetal outcome

Abstract: This study suggests that one in six women in South London are using drugs in early pregnancy and that cannabinoid use is associated with a poorer pregnancy outcome.

Cited by 93 publications

References 23 publications

Neonatal abstinence syndrome—postnatal ward versus neonatal unit management

Neonatal abstinence syndrome—postnatal ward versus neonatal unit management

Birth outcomes associated with cannabis use before and during pregnancy

Neonatal Abstinence Syndrome Due to Opioid Abuse in Pregnancy

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