Substance P&dimethyloxallyl glycine‐loaded carboxymethyl chitosan/gelatin hydrogel for wound healing

Abstract

Recent efforts have focused on preparing drug‐loaded hydrogel for wound healing. In order to obtain an ideal hydrogel dressing for skin wound repair, a carboxymethyl chitosan‐gelatin hydrogel was prepared for co‐delivery of SP (substance P) and DMOG (dimethyloxallyl glycine) by a chemical cross‐linking method using genipin as the cross‐linking agent. The synthesized hydrogels have good biocompatibility and physicochemical properties due to the low toxicity of the hydrogel material. The three‐dimensional network structure of the hydrogels supports cell migration and proliferation, and the combination of SP and DMOG drugs exhibited strong effects on cell proliferation. Moreover, the co‐loaded drug hydrogels could significantly promote wound healing in vivo, and provide a potential hydrogel for wound healing.

Preparation and Application of Biomass-based Sprayable Hydrogels

“…Gelatin is derived from collagen by its denaturation and high-temperature hydrolysis and carries the physical and biological properties of a protein that comprises mainly a series of amino acids (Fig. 4) [68][69] . Compared to collagen, gelatin not only has lower immunogenicity and promotes cell adhesion but also retains biocompatibility and biodegradability [70][71] .…”