1989
DOI: 10.1016/0304-3959(89)90078-x
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Substance P and peripheral inflammatory hyperalgesia

Abstract: The hyperalgesic effect of substance P (SP) is usually described as presenting short latency. We now report that multiple injections of sub-threshold doses of SP into the foot pad of a hind paw of rats pre-treated with indomethacin induced a long-lasting hyperalgesia, sensitizing the paw to further challenges with small doses of SP, dopamine or prostacyclin. The sensitizing process also occurred after multiple injections of prostacyclin or prostaglandin E2. The sensitizing effect induced by SP, prostaglandin E… Show more

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Cited by 88 publications
(37 citation statements)
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“…We therefore tested the peripheral effects of SP on the excitability of nociceptive neurons in vivo and compared them with the effects of BK. First we confirmed the previously characterized (7,39) hyperalgesic effect induced by plantar injection of SP. In accordance with previous studies, the latency of hind paw withdrawal at the presentation of a thermal stimulus was decreased significantly after plantar injection of 10 μM SP in saline (50 μL; 0.5 nmol per site) (Fig.…”
Section: Sp Augments M Current In Sensory Neurons Via Oxidativesupporting
confidence: 85%
“…We therefore tested the peripheral effects of SP on the excitability of nociceptive neurons in vivo and compared them with the effects of BK. First we confirmed the previously characterized (7,39) hyperalgesic effect induced by plantar injection of SP. In accordance with previous studies, the latency of hind paw withdrawal at the presentation of a thermal stimulus was decreased significantly after plantar injection of 10 μM SP in saline (50 μL; 0.5 nmol per site) (Fig.…”
Section: Sp Augments M Current In Sensory Neurons Via Oxidativesupporting
confidence: 85%
“…In this test, the end point is a behavioral response, the freezing reaction. The constant-pressure rat-paw test over the years has been instrumental in many original observations (2,4,6,48,49). The drugs were tested by connection to a 100-ml Hamilton microsyringe.…”
Section: Experimental Protocol For Acute and Persistent Hypernociceptmentioning
confidence: 99%
“…These are distributed differentially throughout both the central nervous system (CNS) and peripheral tissues where they regulate a wide variety of physiological processes including smooth muscle contraction, inflammation, perception of pain, secretion, neurotransmission, and proliferation (Nilsson et al, 1985;Grandordy et al, 1988;Nakamura-Craig and Smith, 1989;Rogers et al, 1989;Mayer et al, 1990;Reid et al, 1990). Neurokinin actions are mediated by three pharmacologically distinct cell-surface receptors classified as NK-1, NK-2, and NK-3 that display limited selectivity toward SP, NKA, and NKB, respectively.…”
Section: Introductionmentioning
confidence: 99%