Substance P and the neurokinin-1 receptor expression in dog ileum with and without inflammation

Polidoro, Giulia; Giancola, Fiorella; Fracassi, Federico; Pietra, Marco; Bettini, Giuliano; Asti, Martina; Chiocchetti, Roberto

doi:10.1016/j.rvsc.2017.06.002

Cited by 9 publications

(8 citation statements)

References 69 publications

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“…This is congruent with the phenomenon of neural plasticity, described by many authors as an adaptation in ENS neurons to disturbances of homeostasis and pathological factors manifested by the change of neurochemical features of neurons, overexpression of certain genes, or a reduction in the expression of others [32]. The plasticity of ENS neurons has been confirmed in studies demonstrating the effect of pathological gut conditions, intoxications, and other experimental treatments in numerous animal models and humans [13,15,18,19,21,25,33].…”

Section: Discussionsupporting

confidence: 82%

“…This is consistent with the current knowledge regarding their physiological functions. In the digestive tract, substance P participates in the regulation of gastrointestinal motility, affects endothelial ion transport, and increases vascular permeability in inflammatory tissues [25]. SP is also involved in pain neurotransmission and the modulation of autonomic stimulus flow [26].…”

Section: Discussionmentioning

confidence: 99%

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Influence of Acrylamide Administration on the Neurochemical Characteristics of Enteric Nervous System (ENS) Neurons in the Porcine Duodenum

Palus¹,

Całka²

2019

IJMS

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The digestive tract, especially the small intestine, is one of the main routes of acrylamide absorption and is therefore highly exposed to the toxic effect of acrylamide contained in food. The aim of this experiment was to elucidate the effect of low (tolerable daily intake—TDI) and high (ten times higher than TDI) doses of acrylamide on the neurochemical phenotype of duodenal enteric nervous system (ENS) neurons using the pig as an animal model. The experiment was performed on 15 immature gilts of the Danish Landrace assigned to three experimental groups: control (C) group—pigs administered empty gelatine capsules, low dose (LD) group—pigs administered capsules with acrylamide at the TDI dose (0.5 μg/kg body weight (b.w.)/day), and the high dose (HD) group—pigs administered capsules with acrylamide at a ten times higher dose than the TDI (5 μg/kg b.w./day) with a morning feeding for 4 weeks. Administration of acrylamide, even in a low (TDI) dose, led to an increase in the percentage of enteric neurons immunoreactive to substance P (SP), calcitonin gene-related peptide (CGRP), galanin (GAL), neuronal nitric oxide synthase (nNOS), and vesicular acetylcholine transporter (VACHT) in the porcine duodenum. The severity of the changes clearly depended on the dose of acrylamide and the examined plexus. The obtained results suggest the participation of these neuroactive substances in acrylamide-inducted plasticity and the protection of ENS neurons, which may be an important line of defence from the harmful action of acrylamide.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Influence of Acrylamide Administration on the Neurochemical Characteristics of Enteric Nervous System (ENS) Neurons in the Porcine Duodenum

Palus¹,

Całka²

2019

IJMS

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“…This thesis is all the more probable since previous studies have suggested the participation of neuronal NRG1 in the conduction of sensory and/or pain stimuli [ 43 ]. Moreover, it is known that SP is an important factor which regulates intestinal motility and secretion [ 44 , 45 ]. Contrary to VIP and NO which, as mentioned above, have clear inhibitory effects on the gastrointestinal muscles [ 40 , 41 ], the impact of SP on intestinal motility is not uniquely defined.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Bisphenol A (BPA) on the Occurrence of Selected Active Substances in Neuregulin 1 (NRG1)-Positive Enteric Neurons in the Porcine Large Intestine

Makowska

Szymańska

Całka

et al. 2021

IJMS

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Bisphenol A (BPA) is a substance used in the manufacture of plastics which shows multidirectional adverse effects on living organisms. Since the main path of intoxication with BPA is via the gastrointestinal (GI) tract, the stomach and intestine are especially vulnerable to the impact of this substance. One of the main factors participating in the regulation of intestinal functions is the enteric nervous system (ENS), which is characterized by high neurochemical diversity. Neuregulin 1 (NRG1) is one of the lesser-known active substances in the ENS. During the present study (performed using the double immunofluorescence method), the co-localization of NRG1 with other neuronal substances in the ENS of the caecum and the ascending and descending colon has been investigated under physiological conditions and after the administration of BPA. The obtained results indicate that NRG1-positive neurons also contain substance P, vasoactive intestinal polypeptide, a neuronal isoform of nitric oxide synthase and galanin and the degree of each co-localization depend on the type of enteric plexus and the particular fragment of the intestine. Moreover, it has been shown that BPA generally increases the degree of co-localization of NRG1 with other substances.

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“…There are three kinds of tachykinin receptors: NK 1 receptor, NK 2 receptor plus NK 3 receptor. SP comes from the PPT and applies its biological effects on target cells by interrelating mostly with the NK 1 receptor [53], since SP binds preferentially to NK 1 receptor [21]. NEP, as a major cell surface proteolytic enzyme, P < 0.05 vs. Group CG, † P < 0.05 vs. Group V, § P < 0.05 vs. Group M, || P < 0.05 vs. Group GL, ¶ P < 0.05 vs. Group GM.…”

Section: Discussionmentioning

confidence: 99%

Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems

Tian

Qian

et al. 2019

J Nat Med

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Gingerol, a biologically active component in ginger, has shown antiemetic properties. Our study aimed to explore the underlying mechanisms of gingerol on protecting rats and minks from chemotherapy-induced nausea and vomiting. The preventive impact of gingerol was evaluated in the pica model of rats and the vomiting model of minks induced by cisplatin at every 6 h continuously for a duration of 72 h. Animals were arbitrarily separated into blank control group, simple gingerol control group, cisplatin control group, cisplatin + metoclopramide group, cisplatin + three different doses gingerol group (low-dose; middle-dose; high-dose). The area postrema as well as ileum damage were assessed using H&E stain. The levels of 5-TH, 5-HT3 receptor, TPH, SERT, SP, NK1 receptor, PPT, NEP, DA, D2R, TH, and DAT were determined using immunohistochemistry or qRT-PCR in rats and minks. All indicators were measured in the area postrema along with ileum. The kaolin intake by rats and the incidence of CINV of minks were significantly decreased after pretreatment with gingerol in a dosage-dependent way for the duration of 0–24-h and 24–72-h. Gingerol markedly decreased the levels of 5-TH, 5-HT3 receptor, TPH, SP, NK1 receptor, PPT, DA, D2R, TH, alleviated area postrema as well as ileum damage, and increased the accumulation of SERT, NEP, DAT in the area postrema along with ileum of rats and minks. Gingerol alleviates cisplatin-induced kaolin intake of rats and emesis of minks possibly by regulating central and peripheral 5-HT system, SP system and DA system. Graphic abstract

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Substance P and the neurokinin-1 receptor expression in dog ileum with and without inflammation

Cited by 9 publications

References 69 publications

Influence of Acrylamide Administration on the Neurochemical Characteristics of Enteric Nervous System (ENS) Neurons in the Porcine Duodenum

Influence of Acrylamide Administration on the Neurochemical Characteristics of Enteric Nervous System (ENS) Neurons in the Porcine Duodenum

The Influence of Bisphenol A (BPA) on the Occurrence of Selected Active Substances in Neuregulin 1 (NRG1)-Positive Enteric Neurons in the Porcine Large Intestine

Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems

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