Substance P as a Transmitter Candidate

Nicoll, Roger A.; Schenker, C; Leeman, Susan E.

doi:10.1146/annurev.ne.03.030180.001303

Cited by 515 publications

(140 citation statements)

References 147 publications

(143 reference statements)

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“…Substance P produces widespread vasodilatation (flare) on injection into human skin (Hagermark, Hokfelt & Pernow, 1978) and there is evidence for its release from the central terminals of nociceptive afferent fibres (Nicoll, Schenker & Leeman, 1980). These findings are consistent with the proposal that flare around regions of skin injury may involve the release of substance P from nerve terminals (Burnstock, 1977;Henry, 1977;Hagermark, et al, 1978).…”

Section: Introductionsupporting

confidence: 70%

Vascular and Sensory Responses of Human Skin to Mild Injury After Topical Treatment With Capsaicin

Carpenter

Lynn

1981

British J Pharmacology

235

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1 Immediately after several topical applications of capsaicin at 2-hourly intervals, human forearm skin would no longer develop flare (vasodilatation) around a small injury. At the same time heat pain thresholds were reduced on average by 3.5°C. These results are consistent with block by capsaicin of the effector side of the axon reflex, perhaps by depleting nerve terminals of substance P. 2 Over a period from several days to several weeks after treatment, flare was diminished and heat pain thresholds were slightly elevated. These changes may be due to long-lasting damage of cutaneous nerve terminals by capsaicin.

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Section: Introductionsupporting

confidence: 70%

Vascular and Sensory Responses of Human Skin to Mild Injury After Topical Treatment With Capsaicin

Carpenter

Lynn

1981

British J Pharmacology

235

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“…Jessell, Iversen & Kanazawa, 1976;Fahrenkrug, laglund, Jodal, Lundgren, Olbe & de Muckadell, 1978). Thus, peptides may play an aiportant role in intercellular communication, plausibly functioning as neurotrans-mitters (for reviews, see Nicoll, Schenker & Leeman, 1980;Snyder, 1980), hormones (Scharrer & Scharrer, 1963) or trophic factors (Jessell, Siegel & Fischbach, 1979).…”

Section: Introductionmentioning

confidence: 99%

Peptidergic transmission in sympathetic ganglia of the frog.

Jan¹,

Jan²

1982

The Journal of Physiology

370

226

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SUMMARY1. A slow synaptic potential recorded in neurones of sympathetic ganglia of bullfrog, the late slow e.p.s.p., is probably mediated by a peptide resembling luteinizing hormone-releasing hormone (LHRH), because (1) a LHRH-like peptide is contained in preganglionic nerve terminals and is released upon nerve stimulation, (2) application of LHRH to ganglion cells mimics the effects of the natural transmitter for the late slow e.p.s.p., and (3) the pharmacological properties of LHRH and the natural transmitter for the late slow e.p.s.p. are similar.2. Neurones in frog sympathetic ganglia are also depolarized by substance P. The

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“…It has been postulated that axon reflex flare is produced by release of SP from nociceptive sensory afferent terminals in the skin (Burnstock, 1977;Henry, 1977), and it has been demonstrated that SP is released from the central terminals of such nociceptive fibres (Nicoll, Schenker & Leeman, 1980). Topical capsaicin produces local desensitization of skin to chemogenic noxious agents (Jansco, 1960), possibly by depleting SP in nerve terminals (see Carpenter & Lynn, 1981).…”

Section: Introductionmentioning

confidence: 99%

Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin

Anand

Bloom

McGregor

1983

British J Pharmacology

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Wheal and flare reactions are described following intradermal injections of somatostatin, vasoactive intestinal polypeptide, substance P and histamine in normal human forearm skin. Bombesin failed to produce a significant wheal and flare. Pretreatment of skin with capsaicin in all cases dramatically inhibited the flare but not the wheal. This result is in accord with the hypothesis that capsaicin blocks the effector side of the axon reflex, perhaps by depleting nerve terminals of vasodilatory peptide(s).

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Substance P as a Transmitter Candidate

Cited by 515 publications

References 147 publications

Vascular and Sensory Responses of Human Skin to Mild Injury After Topical Treatment With Capsaicin

Vascular and Sensory Responses of Human Skin to Mild Injury After Topical Treatment With Capsaicin

Peptidergic transmission in sympathetic ganglia of the frog.

Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin

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