Substance P-containing nerve fibres in large peripheral blood vessels of the rat

Barja, Francisco; Mathison, Ron; Huggel, H

doi:10.1007/bf00214982

Cited by 88 publications

(28 citation statements)

References 29 publications

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“…Role of CGRP and SP in the vascular walls and ILG The occurrence of SP-or CGRP-immunoreactive fibers in association with arteries as well as sympathetic and parasympathetic ganglia is known, and their possible origin has been suggested to be collaterals from primary sensory nerve fibers (BAKER et al, 1980;MATTHEWS and CUELLO, 1982;BARJA et al, 1983;LUNDBERG et al, 1984b;SUZUKI et al, 1989). If the SP-and CGRP-immunoreactive lingual perivascular fibers and CGRP-immunoreactive varicose fibers in the ILG are collaterals of primary sensory neurons, stimulation of the sensory terminals would directly influence vascular function and regulate parasympathetic ganglionic activity by the peripheral axon-reflex mechanisms.…”

Section: Innervation Of Dog Tongue 513mentioning

confidence: 99%

An Immunohistochemical Study of Sensory and Autonomic Innervation of the Dog Tongue with Special Reference to Substance P- and Calcitonin Gene-Related Peptide-Containing Fibers in Blood Vessels and the Intralingual Ganglia.

Hino

Masuko

Katsuki

1993

Archives of Histology and Cytology

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Section: Innervation Of Dog Tongue 513mentioning

confidence: 99%

An Immunohistochemical Study of Sensory and Autonomic Innervation of the Dog Tongue with Special Reference to Substance P- and Calcitonin Gene-Related Peptide-Containing Fibers in Blood Vessels and the Intralingual Ganglia.

Hino

Masuko

Katsuki

1993

Archives of Histology and Cytology

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“…1 Sensory afferent nerves have cell bodies located in the dorsal root ganglia and send efferent processes to a variety of cardiovascular tissues. [2][3][4] It has been established that sensory afferent fibers release a variety of vasodilator neuropeptides, eg, calcitonin gene-related peptide (CGRP) and substance P, in response to local stimuli. 5 These vasodilator neuropeptides chronically released from sensory nerves may play a role in blood pressure regulation because it has been demonstrated that altered synthesis or release of these vasodilator neuropeptides occurs in genetic and experimental hypertensive animal models.…”

mentioning

confidence: 99%

Rapid Communication: Salt-Sensitive Hypertension Induced by Sensory Denervation

Wang

Qiu

1998

Hypertension

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Abstract-To test the novel hypothesis that neonatal degeneration of capsaicin-sensitive sensory nerves causes the rat to respond to a salt load with a significant and sustained rise in blood pressure, newborn Wistar rats were given 50 mg/kg capsaicin subcutaneously on the 1st and 2nd day of life. Control rats were treated with vehicle. Immediately after the weanling period, male rats were divided into 4 groups and fed different sodium diets for 2 weeks: capsaicin pretreatment plus high sodium diet (4%, CAP-HS), capsaicin plus normal sodium diet (0.5%, CAP-NS), control plus high sodium diet (CON-HS), and control plus normal sodium diet (CON-NS). Both tail-cuff systolic blood pressure and mean arterial pressure with anesthesia were significantly higher in CAP-HS than in CAP-NS, CON-HS, and CON-NS (PϽ0.05), but they were not different among the latter 3 groups. Radioimmunoassay revealed that levels of calcitonin gene-related peptide in dorsal root ganglia were markedly decreased by capsaicin treatment (PϽ0.05). Twenty-four-hour urine volume and urine sodium excretion were significantly lower in CAP-HS than in CON-HS but were higher in CAP-HS and CON-HS compared with CAP-NS and CON-NS (PϽ0.05). Urine potassium excretion was not different among the 4 groups. Thus, this study provides the first evidence that neonatal degeneration of capsaicin-sensitive sensory nerves renders the rat salt-sensitive in terms of blood pressure regulation. Furthermore, our data suggest that neonatal capsaicin treatment may impair renal sodium and water excretion responses to high sodium intake. This model will provide a novel experimental paradigm for exploring underlying molecular mechanisms linked with salt-sensitive hypertension and sensory nerve function. (Hypertension. 1998;32:649-653.)

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“…In addition to the classical transmitters NE and acetylcholine (ACh), co-transmitters have been identified in perivascular nerves, such as the purinergic component in sympathetic transmission (17), and vasoactive neuropeptides such as substance P (SP) and CGRP have been shown to be present in some blood vessels (18,19). In our experimental system (in guanethidine-treated ring preparations), exogenously added SP (10-6 M); adenosine (2 x 10-6 M), a purine (P1)-receptor agonist; and a,(3-methylene ATP (10-6 M), a purine (P2)-receptor agonist, did not mimic the observed effect of electrical stimulation (Fig.…”

Section: Responses To Electrical Stimulationmentioning

confidence: 99%

Calcitonin Gene-Related Peptide Mediated Neurogenic Vasorelaxation in the Isolated Canine Lingual Artery

Kobayashi¹,

Todoki²,

Ozono

et al. 1995

Japanese Journal of Pharmacology

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ABSTRACT-The nature of neurogenic relaxation was investigated in ring preparations of canine lingual artery. In all experiments, the preparations were previously treated with guanethidine (5 x 10-6 M) to block neurogenic constrictor responses. In the presence of norepinephrine (10-5 M) to induce tone, electrical stimulation (10 V, 4 to 16 Hz, for 45 sec) produced relaxation of the rings in an endothelium-independent fashion. The relaxant response in endothelium-denuded rings was not changed by propranolol (10-5 M), and atropine (10-5 M) did not affect the relaxation elicited by electrical stimulation in endothelium-intact rings. 1VG-monomethyl-L-arginine (10-4 M) or 1VG-nitro-L-arginine methyl ester (10-4 M), a nitric oxide (NO) synthase inhibitor, had no effect on the electrical stimulation-induced relaxation of endotheliumdenuded rings. Human calcitonin gene-related peptide (CGRP)-(8 -37) (2 x 10-8 M), a CGRP I-receptor antagonist, inhibited neurogenic relaxation of endothelium-denuded rings; substance P (10-6 M) failed to mimic the observed effect of electrical stimulation. The demonstrated effect of electrical stimulation was inhibited by glibenclamide (10-5 M), but not tetraethylammonium (2 x 10-4 M); glibenclamide abolished the relaxation in response to exogenous CGRP or the ATP-sensitive K+ channel opener cromakalim (10-6 M) in endothelium-denuded rings. Moreover, tetrodotoxin (3.13 x 10-6 M) inhibited the relaxation of endothelium-denuded rings induced by electrical stimulation. The relaxation was selectively inhibited when endogenous CGRP had been depleted from perivascular nerves by capsaicin (10-6 M). These results suggest that CGRP, but not NO, released from non-adrenergic non-cholinergic nerves by electrical stimulation produces relaxation of canine lingual artery that is mediated by activation of CGRP1 receptors.Keywords: Lingual artery, Calcitonin gene-related peptide, Glibenclamide, Adenosine 5 triphosphate-sensitive potassium channel, Non-adrenergic non-cholinergic nerve *To whom correspondence should be addressed .The inhibitory mechanical responses of the rabbit lingual artery consisted of two components; one is atropinesensitive but the other is a non-cholinergic component(1). This type of mixed dilator response is not unusual; it has been noted in a number of different tissues including the cat salivary gland (2), nasal mucosa (3), tongue (4) and the dog hind limb (5). The identity of the noncholinergic inhibitory transmitter in these tissues is not known. Calcitonin gene-related peptide (CGRP), a 37-amino acid peptide, is synthesized via the alternative processing of the primary RNA-transcript of the calcitonin gene (6, 7). CGRP has been shown to be widely distributed in the central and peripheral nervous system (8), and it also exists in nerve fibers throughout the cardiovascular system (9). CGRP is one of the most potent vasodilators known (10). The first goal of this study is to determine whether CGRP is involved in the neurogenic relaxation in canine lingual artery. Recently, Nelson et ...

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Substance P-containing nerve fibres in large peripheral blood vessels of the rat

Cited by 88 publications

References 29 publications

An Immunohistochemical Study of Sensory and Autonomic Innervation of the Dog Tongue with Special Reference to Substance P- and Calcitonin Gene-Related Peptide-Containing Fibers in Blood Vessels and the Intralingual Ganglia.

An Immunohistochemical Study of Sensory and Autonomic Innervation of the Dog Tongue with Special Reference to Substance P- and Calcitonin Gene-Related Peptide-Containing Fibers in Blood Vessels and the Intralingual Ganglia.

Rapid Communication: Salt-Sensitive Hypertension Induced by Sensory Denervation

Calcitonin Gene-Related Peptide Mediated Neurogenic Vasorelaxation in the Isolated Canine Lingual Artery

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