Substance P enhances antigen-evoked mediator release from human nasal mucosa

Baumgarten, C; Witzel, A.; Kleine-Tebbe, J.; Kunkel, G.

doi:10.1016/0196-9781(95)02057-8

Cited by 28 publications

(22 citation statements)

References 35 publications

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“…For example, the neuropeptide substance P (SP) produces a number of effects in animal models which are consistent with the symptomatology observed in rhinitic patients including increased nasal blood flow, microvascular leakage, mucus secretion and sneezing [6, 7, 8, 9]. Likewise, in allergic rhinitis patients, SP elicits nasal obstruction, increased nasal blood flow, microvascular leakage and inflammatory cell recruitment [10, 11, 12]. In fact, SP produced a greater increase in nasal resistance in allergic rhinitis patients than in control subjects [13].…”

Section: Introductionmentioning

confidence: 77%

“…increased nasal blood flow, microvascular leakage, mucus secretion and sneezing, of allergic airway disease, such as rhinitis [6, 7, 8, 9]. In addition to the effects of the neuropeptide which have been shown to be consistent with the rhinitic phenotype, SP has also been reported to enhance antigen-evoked mediator release from human nasal mucosa [10]. In further support of the hypothesized role of the mediator in the disease, SP was found in nasal lavages following antigen challenge in allergic individuals [37, 38, 39].…”

Section: Discussionmentioning

confidence: 99%

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A Role for Histamine and Substance P in Immediate Allergic Responses in Guinea Pig Airways: Characterization of MDL 108,207DA, a Dual H<sub>1</sub> / NK-1 Receptor Antagonist

Kudlacz¹,

Shatzer²,

Logan³

et al. 1998

Int Arch Allergy Immunol

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Background: Histamine is a critical mediator of immediate hypersensitivity reactions. Sensory neuropeptides, such as substance P (SP), may also contribute to acute inflammatory responses. A compound which antagonizes both H₁ and NK-1 receptors, such as MDL 108,207DA, may present a significant therapeutic advantage over pure antihistamines. Methods: The binding affinity of MDL 108,207DA for H₁ and NK-1 receptors was evaluated and its potency of antagonism evaluated in vitro. The in vivo antagonism of SP- or histamine-induced microvascular leakage in guinea pig airways was examined. A role for these mediators in antigen-induced microvascular leakage in ovalbumin-sensitized guinea pig airways was examined using MDL 108,207DA as well as the NK-1-selective antagonist FK888 and the H₁-selective antagonist pyrilamine alone or in combination. Results: The affinity of MDL 108,207DA for H₁ and NK-1 receptors is similar to that of receptor-selective antagonists. The compound inhibits both receptors in vitro and in vivo with comparable potencies for each. The efficacy of FK888 in combination with pyrilamine and MDL 108,207DA on antigen-induced microvascular leakage in sensitized guinea pig airways supports a role for both SP and histamine in early allergic responses. Conclusion: The contribution of both SP and histamine to immediate hypersensitivity reactions supports the utility of NK-1 and H₁ receptor antagonist therapy. MDL 108,207DA incorporates both activities into the same compound and, as a result, may be useful in the treatment of allergic diseases.

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Section: Introductionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

A Role for Histamine and Substance P in Immediate Allergic Responses in Guinea Pig Airways: Characterization of MDL 108,207DA, a Dual H<sub>1</sub> / NK-1 Receptor Antagonist

Kudlacz¹,

Shatzer²,

Logan³

et al. 1998

Int Arch Allergy Immunol

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“…In 1995, Baumgarten et al [14] stated that "there is much evidence suggesting that neuropeptides play an important role in the pathogenesis of airway disease and the diverse properties of substance P include vasodilatation vascular permeability and leukocyte chemotaxis." It has been shown recently that patients with migraine without aura with normal nasal mucosa will have severe swelling and edema of the nasal mucosa during a migraine attack, which became normal again after treatment with triptans [15].…”

Section: Contact Points and Migraine: A Positive Feedback Loopmentioning

confidence: 99%

Migraine and intranasal contact point headache: Is there any connection?

Behin

Lipton²,

Bigal³

2006

Current Science Inc

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It has been suggested that contact point can trigger headache in individuals with migraine. In this article, we review the anatomy of the sinonasal cavity. We then define contact points and discuss the pathophysiology of contact point headaches. We propose a theory to explain the relationship between migraines and contact points. We close by presenting our personal casuistic in the surgical treatment of patients with contact point and refractory headaches. In migraineurs with contact point, surgery may improve the headaches.

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“…The details of the mechanisms of this inflammation in the human respiratory mucosa are still unknown. Involvement of mast cells has been shown in human skin, but not in mucosa taken from the nose, adenoids, tonsils and lungs [5]. Some evidence now exists for capsaicin controlling severe non-infectious non-allergic rhinitis and possibly being effective in the treatment of recurrent nasal polyps [8,20].…”

Section: Introductionmentioning

confidence: 99%

Effect of cromolyn pre-treatment on capsaicin-induced rhinitis in rats

Baudoin

Kalogjera

Ferenčić

et al. 1999

European Archives of Oto-Rhino-Laryngology

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The effect of cromolyn sodium local pre-treatment on capsaicin-induced rhinitis in rats was studied by analyzing tissue changes due to edema, inflammatory cell infiltration and IgA upregulation. Nasal mucosa samples were stained with hematoxylin-eosin and examined immunohistochemically with monoclonal IgA antibodies. Changes were analyzed at 6, 12 and 72 h after capsaicin treatment and were scored semiquantitatively. Results showed that local cromolyn pre-treatment modified all parameters observed in the nasal mucosa following capsaicin-induced rhinitis in the rats.

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Substance P enhances antigen-evoked mediator release from human nasal mucosa

Cited by 28 publications

References 35 publications

A Role for Histamine and Substance P in Immediate Allergic Responses in Guinea Pig Airways: Characterization of MDL 108,207DA, a Dual H<sub>1</sub> / NK-1 Receptor Antagonist

A Role for Histamine and Substance P in Immediate Allergic Responses in Guinea Pig Airways: Characterization of MDL 108,207DA, a Dual H<sub>1</sub> / NK-1 Receptor Antagonist

Migraine and intranasal contact point headache: Is there any connection?

Effect of cromolyn pre-treatment on capsaicin-induced rhinitis in rats

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