Substance P in medullary carcinoma of the thyroid

Skrabanek, Petr; Cannon, D.; Dempsey, Jack; Kirrane, James; Neligan, M.; Powell, David

doi:10.1007/bf01963325

Cited by 38 publications

(20 citation statements)

References 11 publications

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“…Our results corroborate earlier findings indicating that serotonin and TK are often expressed in the same cell (1,28,29). Previously, focal SP expression had been described in a minor subset of medullary thyroid carcinoma and pheochromocytomas (8)(9)(10)30). In our study, TK-IR was not found in nonserotonin-producing endocrine tumors; however, our sample population is too small to rule out the existence of other TK-IR endocrine tumors.…”

Section: Discussionsupporting

confidence: 92%

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Tachykinins in endocrine tumors and the carcinoid syndrome

Cunningham¹,

Janson²,

Agarwal³

et al. 2008

European Journal of Endocrinology

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Objective: A new antibody, active against the common tachykinin (TK) C-terminal, was used to study TK expression in patients with endocrine tumors and a possible association between plasma-TK levels and symptoms of diarrhea and flush in patients with metastasizing ileocecal serotonin-producing carcinoid tumors (MSPCs). Method: TK, serotonin and chromogranin A (CgA) immunoreactivity (IR) was studied by immunohistochemistry in tissue samples from 33 midgut carcinoids and 72 other endocrine tumors. Circulating TK (P-TK) and urinary-5 hydroxyindoleacetic acid (U-5HIAA) concentrations were measured in 42 patients with MSPCs before treatment and related to symptoms in patients with the carcinoid syndrome. Circulating CgA concentrations were also measured in 39 out of the 42 patients. Results: All MSPCs displayed serotonin and strong TK expression. TK-IR was also seen in all serotoninproducing lung and appendix carcinoids. None of the other tumors examined contained TK-IR cells. Concentrations of P-TK, P-CgA, and U-5HIAA were elevated in patients experiencing daily episodes of either flush or diarrhea, when compared with patients experiencing occasional or none of these symptoms. In a Spearman partial rank test, the correlation of P-TK with daily diarrhea was independent of both U-5HIAA and CgA levels. Conclusion: We found that TK synthesis occurs in serotonin-IR tumors and that P-TK levels are significantly correlated with symptoms of flush and diarrhea in patients with MSPCs. This is, to our knowledge, the first report demonstrating an independent correlation of P-TKs with carcinoid diarrhea, a symptom that is customarily regarded as serotonin mediated. Further investigations may present opportunities for new therapeutic possibilities.European Journal of Endocrinology 159 275-282

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Section: Discussionsupporting

confidence: 92%

“…TKs have also been found in other endocrine tumors, such as appendix carcinoids (5), serotonin-producing lung carcinoids (6), ovarian carcinoids (7), medullary carcinoma of the thyroid (8,9), and in pheochromocytomas (10).…”

Section: Introductionmentioning

confidence: 99%

Tachykinins in endocrine tumors and the carcinoid syndrome

Cunningham¹,

Janson²,

Agarwal³

et al. 2008

European Journal of Endocrinology

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“…There was, however, marked reduction in the transit time of colonic contents [58]. Prostaglandins E2 and F2α, serotonin, and substance P are raised in patients with medullary thyroid cancer [59,60] and have been postulated as being involved in the pathogenesis of the cancer-associated diarrhoea [58]. Currently, it is thought that the cause of the diarrhoea may vary from one individual to another; prostaglandins, serotonin, and calcitonin do remain the likely culprits though [61].…”

Section: Medullary Thyroid Cancer and The Gutmentioning

confidence: 92%

Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review

Kyriacou

McLaughlin

Syed

2015

European Journal of Internal Medicine

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“…S juponicum has been linked with hepatoma [106,111,112,116] and S interculutum has been associated with induced bladder cancers [27,101]. The majority of available information, however, involves S hematobiurn, which has been correlated with a number of malignancies including hydronephrosis [ 1181, ovarian teratoma [68], and bladder cancer [14,74,77,95,99,100,102,110,112,126].…”

Section: Cancer and Schistosomiasismentioning

confidence: 99%

Schistosome related cancers: A possible role for genotoxins

Gentile

1985

Environ. mutagen

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Schistosomiasis has long been associated with cancer. This association is most prevalent between Schistosoma hematobium and bladder cancer. Numerous theories have been proposed to explain the causal link between the parasite infestation and the ensuing neoplasia. One theory that has not received as much attention as others, however, is the role of genotoxins in the neoplastic process. Considering the substantial amount of supportive evidence for the cocarcinogenic effects of schistosomes, concern for the health effects resulting from exposure of infested individuals to either exogenous or endogenous genotoxins is certainly warranted.

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Substance P in medullary carcinoma of the thyroid

Abstract: High levels of substance P-like immunoreactivity were demonstrated by radioimmunoassay in the plasma and tumour of a patient with a medullary carcinoma of the thyroid.

Cited by 38 publications

References 11 publications

Tachykinins in endocrine tumors and the carcinoid syndrome

Tachykinins in endocrine tumors and the carcinoid syndrome

Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review

Schistosome related cancers: A possible role for genotoxins

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