Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio

Yan, Kaixian; Lin, Qin; Tang, Kailiang; Liu, Shuang; Du, Yi; Yu, Xijiao; Li, Shu

doi:10.1186/s12903-020-1017-9

Cited by 37 publications

(20 citation statements)

References 31 publications

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“…Since alveolar bone resorption is a key factor in periodontal disease, the vitamin D receptor (VDR) has been considered as a susceptibility factor in disease progression. Data in the literature support the existence of an association between common polymorphisms affecting candidate genes and periodontal disease [22,24,25].…”

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confidence: 87%

The Impact of Diet, Nutrition and Nutraceuticals on Oral and Periodontal Health

Isola

2020

Nutrients

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Oral and periodontal diseases can determine severe functional, phonatory and aesthetic impairments and are the main cause of adult tooth loss. They are caused by some specific bacteria that provoke an intense local inflammatory response and affect—with particular gravity—susceptible subjects, because of reasons related to genetics and lifestyles (e.g., smoking and home oral hygiene habits). They are more frequent in the disadvantaged segments of society and, in particular, in subjects who have difficulty accessing preventive services and dental care. Some systemic diseases, such as uncontrolled diabetes, can increase their risk of development and progression. Recently, in addition to the obvious considerations of severe alterations and impairments for oral health and well-being, it has been noted that periodontitis can cause changes in the whole organism. Numerous clinical and experimental studies have highlighted the presence of a strong association between periodontitis and some systemic diseases, in particular, cardiovascular diseases, diabetes, lung diseases and complications of pregnancy. The purpose of this editorial is to provide a current and thoughtful perspective on the relationship of diet and natural agents on oral, periodontal diseases, and chewing disorder preventions which may reflect good systemic conditions and related quality of life or to analyze indirect effects through the contribution of diet and nutrition to systemic health in order to obtain a modern diagnostic–therapeutic approach.

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confidence: 87%

The Impact of Diet, Nutrition and Nutraceuticals on Oral and Periodontal Health

Isola

2020

Nutrients

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“…Research indicates insignificant improvement in periodontal health upon supplementation. PD: 0.52 ± 0.03 CAL: n.d. [ 14 , 66 ] B-vitamins B1—Liver, oats, pork, potatoes, eggs B2—Bananas, dairy, green beans B3—Eggs, fish, meat, mushrooms, nuts B5—Avocados, meat, broccoli B7—Raw egg, liver, leafy vegetables, peanuts B9—Cereals, leafy vegetables B12—Animal products Supplementation may accelerate post-surgical healing. PD: 1.57 ± 0.34 [ 53 ] Vitamin C Citrus fruits, vegetables, liver Gingival bleeding and Inflammation are hallmarks of scurvy.…”

Section: Micronutrientsmentioning

confidence: 99%

“…No known effects on periodontal therapy if supplementation used as an adjunct. n.d. [ 14 , 70–72 ] Note: Adapted from Najeeb S, Zafar MS, Khurshid Z, Zohaib S, Almas K. The Role of Nutrition in Periodontal Health: An Update. Nutrients .…”

Section: Micronutrientsmentioning

confidence: 99%

“…Periodontopathogenic bacteria release metabolites and enzymes that aggravate tissue damage and, at the same time, leukocytes and fibroblasts produce various inflammatory mediators, including cytokines, prostaglandins, reactive oxidative species (ROS), proteolytic enzymes and metalloproteinases. [13][14][15][16] The inflammatory infiltrate from periodontal tissues induces tissue and alveolar bone destruction. 17 A variety of nutrients have a major impact on periodontal health.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Factors Affecting the Prevalence and Impact of Periodontal Disease

Santonocito

Polizzi

Palazzo

et al. 2021

CCIDE

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In the last few decades, growing evidence have shown a possible impact of diet and nutrients on oral health. This review aims to describe, in the light of current knowledge, the role of diet, nutrients, and micronutrients in periodontal health and periodontal diseases. A variety of macronutrients and micronutrients could have an impact on periodontal health. The balanced intake of unprocessed complex carbohydrates, vegetable proteins, omega-3 fatty acids, minerals, and vitamins positively affects periodontal inflammation. On the other way, refined carbohydrates, non-vegetable proteins, proinflammatory saturated fatty acids and an unbalanced supply of vitamins and minerals may increase periodontal inflammation. This review will discuss the current evidence that shows how a healthy and balanced diet has anti-inflammatory and protective effects on periodontal health. Therefore, it appears that adopting a correct lifestyle and diet should be encouraged in patients with oral and periodontal disease.

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“…Neuropeptides take part in the process of transmission and modulation of pain and inflammatory process. These neuropeptides include neurokinin A (NK-A), calcitonin gene-related peptide (CGRP), neuropeptide Y (NP-Y), vasoactive intestinal polypeptide (VIP), and substance P (SP), among others [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Neurokinin-1 Receptor Expression Is Associated with Human Dental Pulp Inflammation and Pain Severity

Mehboob

Hassan

Gilani

et al. 2021

BioMed Research International

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Substance P (SP) is a peptide involved in many biological processes, including nociception and inflammation. SP has a high affinity for its receptor neurokinin-1 (NK-1R). SP/NK-1R complex plays a major role in the interactions going on during the onset of dental pain and inflammation. Objective. To identify the expression of NK-1R in healthy and inflamed human dental pulp, as well as to identify any association with severity of dental pain. Methods. This case-control study included ten irreversibly inflamed samples of dental pulp, which were extirpated from patients presenting with chief complaint of dental pain due to caries. Ten healthy pulps, extirpated from those teeth which were indicated for extraction due to orthodontic reasons, were used as the control group. Visual analog scale (VAS) and modified McGill Pain Questionnaire were used to assess the characteristic and severity of pain. Immunohistochemical study was performed using monoclonal antibodies against NK-1R. Results. The results showed that the NK-1R was expressed intensely in patients with higher pain score. The mean pain score in cases was 7.0 ± 2.0 . The healthy dental pulps had negative or mild NK-1R staining of +1 intensity. The NK-1R score in cases was 2.4 ± 0.516 and 0.2 ± 0.4216 in controls. There was significant difference in NK-1R score between both groups ( p value <0.05). There was a strong positive correlation between the pain score and NK-1R expression score. As the pain increased, the NK-1R expression score was also increased (0.95 ∗ ∗ , p value 0.000). Conclusions. NK-1R is overexpressed in inflamed dental pulp. SP/NK-1R modulation may provide a novel approach for the treatment of pulpal inflammation and pain.

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Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio

Cited by 37 publications

References 31 publications

The Impact of Diet, Nutrition and Nutraceuticals on Oral and Periodontal Health

The Impact of Diet, Nutrition and Nutraceuticals on Oral and Periodontal Health

Dietary Factors Affecting the Prevalence and Impact of Periodontal Disease

Enhanced Neurokinin-1 Receptor Expression Is Associated with Human Dental Pulp Inflammation and Pain Severity

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