Substance P stimulates the recovery of bone marrow after the irradiation

An, You Sun; Lee, EunAh; Kang, Mi-Hyun; Hong, Hoon Pyo; Kim, Mi-Ra; Jang, Won Seok; Son, Youngsook; Yi, Jianxun

doi:10.1002/jcp.22447

Cited by 44 publications

(37 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, SP also -sue injury, as shown in radio-induced BM and gastro-intestinal (GI) damages (Kang et al, 2009;Kim et al, , 2010An et al, 2011) and spinal cord injury (Jiang et al, 2012(Jiang et al, , 2013. Multifunctional effects of SP in the process of wound healing propose the SP-peptide as a candidate -ease as well as facilitating tissue repair.…”

Section: Introductionmentioning

confidence: 99%

Long-term comparative study of Substance-P with methylprednisolone on the development of osteoporosis

Hong

Lee

et al. 2014

J. Toxicol. Sci.

Self Cite

View full text Add to dashboard Cite

ABSTRACTuated with regard to diabetes and osteoporosis. Dexamethasone (DEX) and methylprednisolone (MP) were used as comparative drugs. While DEX-injection for 24 weeks developed severe weight loss, unstable blood glucose, and bone loss, SP-injection did not affect blood glucose and bone mass. MP-injec-66 weeks, MP-injection caused unstable blood glucose, alleviation in the age-related increase of body weight, and bone weakness, which was featured by reduction in collagen deposition and trabecular bone volume based on histological and micro CT analysis. However, SP-injection for 66 weeks rather increased collagen deposition, bone volume, and bone density. Therefore, this comparative study suggests that SP, even after long-term usage of effective dose, may not cause side effects such as osteoporosis in compari--er for long-term treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Long-term comparative study of Substance-P with methylprednisolone on the development of osteoporosis

Hong

Lee

et al. 2014

J. Toxicol. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is worthy of note that pretreatment to cultured human mesenchymal stem cells with SP led to a decrease in apoptotic cells after irradiation (101), implying the potential therapeutic use of SP pretreatment in minimizing radiation damage to patients.…”

Section: Tks and Hematopoiesismentioning

confidence: 99%

Tachykinin: recent developments and novel roles in health and disease

Onaga

2014

Biomolecular Concepts

View full text Add to dashboard Cite

Over 80 years has passed since the discovery of substance P (SP), and a variety of peptides of the tachykinin (TK) family have been found and investigated. SP, neurokinin A (NKA), and neurokinin B (NKB) are representative peptides in mammalian species. SP and NKA are major excitatory neurotransmitters in the peripheral nervous system, while NKB is primarily involved in the central nervous system (CNS). Moreover, TK peptides play roles not only as neurotransmitters but also as local factors and are involved in almost all aspects of the regulation of physiological functions and pathophysiological processes. The role of SP as a mediator of pain processing and inflammation in peripheral tissues in coordination with transient receptor potential channels is well established, while novel aspects of TKs in relation to hematopoiesis, venous thromboembolism, tendinopathy, and taste perception have been clarified. In the CNS, the NKB signaling system in the hypothalamus has been shown to play a crucial role in the regulation of gonadotropin hormone secretion and the onset of puberty, and molecular biological studies have elucidated novel prophylaxic activities of TKs against neurogenic movement disorders based on their molecular structure. This review provides an overview of the novel aspects of TKs reported around the world in the last 5 years, with particular focus on nociception, inflammation, hemopoiesis, gonadotropin secretion, and CNS diseases.

show abstract

“…Moreover, SP causes the mobilization of bone marrowderived stem cells to participate in corneal wound healing (19,20). Interestingly, recent evidences have shown that SP activates the EGFR, mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinases (ERKs), and phosphoinositide 3-kinase-Akt (PI3K-Akt) signaling pathways, as well as promotes the healing of inflamed colonic epithelium (21) and possesses antiapoptotic effects in colonocytes (22), dendritic cells (23), tenocytes (24), neutrophils (25), and bone marrow-derived stem cells (26).…”

mentioning

confidence: 99%

Substance P Promotes Diabetic Corneal Epithelial Wound Healing Through Molecular Mechanisms Mediated via the Neurokinin-1 Receptor

et al. 2014

View full text Add to dashboard Cite

Substance P (SP) is a neuropeptide, predominantly released from sensory nerve fibers, with a potentially protective role in diabetic corneal epithelial wound healing. However, the molecular mechanism remains unclear. We investigated the protective mechanism of SP against hyperglycemia-induced corneal epithelial wound healing defects, using type 1 diabetic mice and high glucose–treated corneal epithelial cells. Hyperglycemia induced delayed corneal epithelial wound healing, accompanied by attenuated corneal sensation, mitochondrial dysfunction, and impairments of Akt, epidermal growth factor receptor (EGFR), and Sirt1 activation, as well as decreased reactive oxygen species (ROS) scavenging capacity. However, SP application promoted epithelial wound healing, recovery of corneal sensation, improvement of mitochondrial function, and reactivation of Akt, EGFR, and Sirt1, as well as increased ROS scavenging capacity, in both diabetic mouse corneal epithelium and high glucose–treated corneal epithelial cells. The promotion of SP on diabetic corneal epithelial healing was completely abolished by a neurokinin-1 (NK-1) receptor antagonist. Moreover, the subconjunctival injection of NK-1 receptor antagonist also caused diabetic corneal pathological changes in normal mice. In conclusion, the results suggest that SP-NK-1 receptor signaling plays a critical role in the maintenance of corneal epithelium homeostasis, and that SP signaling through the NK-1 receptor contributes to the promotion of diabetic corneal epithelial wound healing by rescued activation of Akt, EGFR, and Sirt1, improvement of mitochondrial function, and increased ROS scavenging capacity.

show abstract

Substance P stimulates the recovery of bone marrow after the irradiation

Cited by 44 publications

References 35 publications

Long-term comparative study of Substance-P with methylprednisolone on the development of osteoporosis

Long-term comparative study of Substance-P with methylprednisolone on the development of osteoporosis

Tachykinin: recent developments and novel roles in health and disease

Substance P Promotes Diabetic Corneal Epithelial Wound Healing Through Molecular Mechanisms Mediated via the Neurokinin-1 Receptor

Contact Info

Product

Resources

About