Substance use and spine density: a systematic review and meta-analysis of preclinical studies

Oliva, Henrique Nunes Pereira; Prudente, Tiago Paiva; Nunes, Eric J.; Cosgrove, Kelly P.; Radhakrishnan, Rajiv; Potenza, Marc N.; Angarita, Gustavo A.

doi:10.1038/s41380-024-02519-3

Mol Psychiatry

2024

DOI: 10.1038/s41380-024-02519-3

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Substance use and spine density: a systematic review and meta-analysis of preclinical studies

Henrique Nunes Pereira Oliva,

Tiago Paiva Prudente,

Eric J. Nunes

et al.

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Cited by 3 publications

References 131 publications

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Structural neural plasticity evoked by rapid-acting antidepressant interventions

Liao,

Dua,

Wojtasiewicz

et al. 2024

Nat. Rev. Neurosci.

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Structural neural plasticity evoked by rapid-acting antidepressant interventions

Liao,

Dua,

Wojtasiewicz

et al. 2024

Nat. Rev. Neurosci.

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The potential of non-psychedelic 5-HT2A agents in the treatment of substance use disorders: a narrative review of the clinical literature

Pulido-Saavedra,

Borelli,

Kitaneh

et al. 2024

Expert Opinion on Pharmacotherapy

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The Role of Acid-Sensing Ion Channel 1A (ASIC1A) in the Behavioral and Synaptic Effects of Oxycodone and Other Opioids

Fuller,

Andrys,

Gupta

et al. 2024

IJMS

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Opioid-seeking behaviors depend on glutamatergic plasticity in the nucleus accumbens core (NAcc). Here we investigated whether the behavioral and synaptic effects of opioids are influenced by acid-sensing ion channel 1A (ASIC1A). We tested the effects of ASIC1A on responses to several opioids and found that Asic1a−/− mice had elevated behavioral responses to acute opioid administration as well as opioid seeking behavior in conditioned place preference (CPP). Region-restricted restoration of ASIC1A in NAcc was sufficient to reduce opioid CPP, suggesting NAcc is an important site of action. We next tested the effects of oxycodone withdrawal on dendritic spines in NAcc. We found effects of oxycodone and ASIC1A that contrasted with changes previously described following cocaine withdrawal. Finally, we examined α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated and N-methyl-D-aspartic acid (NMDA) receptor-mediated synaptic currents in NAcc. Oxycodone withdrawal, like morphine withdrawal, increased the AMPAR/NMDAR ratio in Asic1a+/+ mice, whereas oxycodone withdrawal reduced the AMPAR/NMDAR ratio in Asic1a−/− mice. A single dose of oxycodone was sufficient to induce this paradoxical effect in Asic1a−/− mice, suggesting an increased sensitivity to oxycodone. We conclude that ASIC1A plays an important role in the behavioral and synaptic effects of opioids and may constitute a potential future target for developing novel therapies.

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Substance use and spine density: a systematic review and meta-analysis of preclinical studies

Cited by 3 publications

References 131 publications

Structural neural plasticity evoked by rapid-acting antidepressant interventions

Structural neural plasticity evoked by rapid-acting antidepressant interventions

The potential of non-psychedelic 5-HT2A agents in the treatment of substance use disorders: a narrative review of the clinical literature

The Role of Acid-Sensing Ion Channel 1A (ASIC1A) in the Behavioral and Synaptic Effects of Oxycodone and Other Opioids

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