Substance use disorder with adult attention deficit hyperactivity disorder and bipolar disorder; a distinct clinical phenothype?

Ceraudo, Giuseppe; Toni, Cristina; Vannucchi, Giulia; Rizzato, Salvatore; Casalini, Francesca; Benvenuti, M; Carlo, A Del; Mosti, N; Dell’Osso, Liliana; Maremmani, Icro; Perugi, Giulio

doi:10.1097/01.yic.0000423297.00530.84

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“…Nineteen studies provided data comparing the prevalence of mood disorders (including depressive disorders and bipolar disorders) between ADHD patients and non-ADHD individuals [6,16,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. In the general populations, the prevalence of any depressive disorder in the non-ADHD group was estimated at 1.2% [16] to 12.5% [35], compared to 8.6% [36] to 55% [6] in the ADHD group.…”

Section: Prevalence Of Mood Disordersmentioning

confidence: 99%

“…In the general population, the prevalence of any bipolar disorder in the non-ADHD group was estimated at 0.2% [35] to 3.6% [16] compared to 4.48% [42] to 35.3% [16] in the ADHD group. In clinical populations, the prevalence of any bipolar disorder in the non-ADHD group was estimated at 2.0% [37] to 19.5% [40], compared to 7.4% [34] to 80.0.% [29] in the ADHD group. There were no differences reported in the prevalence of mood disorders between ADHD and non-ADHD groups in the incarcerated population studies.…”

Section: Prevalence Of Mood Disordersmentioning

confidence: 99%

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The prevalence of psychiatric comorbidities in adult ADHD compared with non-ADHD populations: A systematic literature review

et al. 2022

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Comorbid psychiatric disorders in adults with ADHD are important because these comorbidities might complicate the diagnosis of ADHD and also worsen the prognosis. However, the prevalence of comorbid psychiatric disorders in adult ADHD varies according to the diagnostic tools used and the characteristics of target populations. The purpose of this review was to describe the prevalence of comorbid psychiatric disorders in adults with ADHD compared with adults without ADHD. Thirty-two studies published before August 2022 were identified and classified according to diagnosis of other psychiatric disorder in those with ADHD. The most frequent comorbid psychiatric disorder in the ADHD group was substance use disorder (SUD), followed by mood disorders, anxiety disorders, and personality disorders. The prevalence of these four disorders was higher in the ADHD group, whether or not subjects were diagnosed with other psychiatric disorders. In addition, the diversity of ADHD diagnostic tools was observed. This also might have affected the variability in prevalence of comorbidities. Standardization of ADHD diagnostic tools is necessary in the future.

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