“…Substance abuse seems to be frequently motivated by an attempt to regulate negative private experiences (e.g., Shoal & Giancola, 2001)-indeed, the subjective effectiveness of its utility in that regard predicts relapse (Litman, Stapleton, Oppenheim, Peleg, & Jackson, 1984). Even if substance abuse was initially motivated by other factors, however, as it evolves a variety of drug-related responses emerge (e.g., cravings; withdrawal symptoms) that themselves become the target of experiential avoidance and subsequent drug use (e.g., Nathan, 1997;Toneatto, 1999). Over time, these sources of influence begin to combine and negative affect or cognitions begin to trigger drug-related responses that are then regulated by drug use (Childress et al, 1994).…”