Substance Use Disorders: Sex Differences and Psychiatric Comorbidities

Zilberman, Monica L.; Tavares, Hermano; Blume, Sheila B.; el‐Guebaly, Nady

doi:10.1177/070674370304800103

Cited by 196 publications

(145 citation statements)

References 66 publications

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“…This, and other work showing that women differ from men in terms of prevalence, course, and treatment outcome, 35 reinforces the notion that clinical and policy work in this area require a gendered perspective. Co-occurring disorders are more common among young people but, importantly, trends are again dominated by the age differences across pure disorders.…”

Section: Discussionsupporting

confidence: 76%

Prevalence of Co-Occurring Substance Use and other Mental Disorders in the Canadian Population

et al. 2008

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Objective: Population health surveys around the world have studied the epidemiology of comorbid substance use disorders (SUDs) and other mental disorders as part of larger efforts to assess needs and direct integrated planning and delivery of services. This study presents the first national assessment in Canada of the prevalence of co-occurring SUDs and other mental disorders, with attention to differences by substance problem severity, sex, age, and region. Methods: This work is a secondary analysis of data from the 2002 Canadian Community Health Survey: Mental Health and Well-Being. The sample was obtained using a multistage stratified cluster design ( n = 36 984, response rate = 77%). Results: The 12-month population prevalence of co-occurring disorders was 1.7%. The 12-month prevalence of other mental disorders was higher among those with illicit drug, relative to alcohol, problems and among those with dependence, compared with those with less severe problems. Sex and age differences mirrored population differences in pure disorders. Salient regional differences included the higher rate of co-occurring disorders in British Columbia and the lower rates in Quebec. Conclusions: Cross-study comparisons are hampered by methodological differences; however, these Canadian rates are at the lower end of the range reported internationally. This might have resulted from the exclusion of several disorders known to be highly comorbid with SUDs. Nonetheless, prevalence is high in certain subgroups, and efforts under way to improve Canada's substance abuse and mental health services should continue to ensure that adequate attention is directed to the needs of people with co-occurring disorders.

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Section: Discussionsupporting

confidence: 76%

Prevalence of Co-Occurring Substance Use and other Mental Disorders in the Canadian Population

et al. 2008

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“…Considering female rhesus monkeys in the current study were less sensitive to the behavioral effects of quinpirole, it is likely that drug potency will be a critical variable in future studies investigating D3R compounds as a treatment option. As there are known sex differences in drug pharmacokinetics and pharmacodynamics (see Gandhi et al, 2004, for review) and also that the fields of neuroscience and pharmacology publish predominately male subject-based studies (Beery and Zucker, 2011), the present findings support the consideration of sex differences as a critical variable in the development of treatment strategies for drug abuse (Zilberman et al, 2003;see Becker and Hu, 2008). Finally, this and other studies (Boileau et al, 2012;Payer et al, 2014) have associated D3R availability and a history of psychostimulant abuse but have yet to establish the nature of this relationship.…”

Section: Discussionsupporting

confidence: 69%

“…There is accumulating evidence of sex differences in cocaine abuse (O'Brien and Anthony, 2005), including greater vulnerability in initiating drug use, progressing to dependence faster, and more adverse physical, mental, and social consequences of abuse in women compared with men (Zilberman et al, 2003;Greenfield et al, 2010). Several animal models using female subjects have supported these observations (e.g., Lynch et al, 2002;Mello et al, 2007;Mello, 2010;Nader et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys

Martelle

Nader

Czoty

et al. 2014

J Pharmacol Exp Ther

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The dopamine (DA) D 3 receptor (D3R) has been associated with impulsivity, pathologic gambling, and drug addiction, making it a potential target for pharmacotherapy development. Positron emission tomography studies using the D3R-preferring radioligand [ 11 C]PHNO ([ 11 C](+)-propyl-hexahydro-naphtho-oxazin) have shown higher binding potentials in drug abusers compared with control subjects. Preclinical studies have examined D3R receptor activation using the DA agonist quinpirole and the unconditioned behavior of yawning. However, the relationship between quinpirole-elicited yawning and D3R receptor availability has not been determined. In Experiment 1, eight drug-naive male rhesus monkeys were scanned with [ 11 C]PHNO, and the ability of quinpirole (0.01-0.3 mg/kg i.m.) to elicit yawning was examined. Significant positive (globus pallidus) and negative (caudate nucleus, putamen, ventral pallidum, and hippocampus) relationships between D3R receptor availability and quinpirole-induced yawns were noted. Experiment 2 replicated earlier findings that a history of cocaine self-administration (n = 11) did not affect quinpirole-induced yawning and extended this to examine monkeys (n = 3) with a history of methamphetamine (MA) selfadministration and found that monkeys with experience selfadministering MA showed greater potency and significantly higher quinpirole-elicited yawning compared with controls. Finally, quinpirole-elicited yawning was studied in drug-naive female monkeys (n = 6) and compared with drug-naive male monkeys (n = 8). Sex differences were noted, with quinpirole being more potent and eliciting significantly more yawns in males compared with females. Taken together these findings support the use of quinpirole-elicited yawning as a behavioral tool for examining D3R activation in monkeys and that both drug history and sex may influence individual sensitivity to the behavioral effects of D3R compounds.

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“…Os dados deste estudo revelam que, aproximadamente, metade dos usuários dessas drogas foi classificada como dependente, com exceção da cocaína, em que a proporção de dependentes era menor, em torno de 30%. Houve maior proporção de dependentes homens para o tabaco e solventes, mostrando que o sexo feminino busca mais atendimento para as dependências que o masculino, à semelhança do que ocorre para outros problemas de saúde 35 , visto que as mulheres costumam ter uma representatividade populacional para dependência menor que os homens 55 .…”

Section: Discussionunclassified

Perfil dos usuários do serviço de teleatendimento sobre drogas de abuso VIVAVOZ

Souza

Kohlrausch

Mazoni

et al. 2008

Rev. psiquiatr. Rio Gd. Sul

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INTRODUÇÃO: O abuso de drogas é um problema importante de saúde pública, e intervenções telefônicas são utilizadas como uma modalidade de tratamento. Objetivou-se descrever o perfil sociodemográfico, o padrão de consumo e a dependência de substâncias psicoativas dos usuários que buscaram auxílio em um serviço de teleatendimento para drogas de abuso. MÉTODOS: Foram utilizados os dados do 1º ano de funcionamento do serviço, coletados por consultores previamente capacitados, através de protocolo informatizado. Foram aplicados instrumentos para caracterização sociodemográfica, padrão de consumo e dependência dos usuários. Utilizou-se estatística descritiva para estimar a distribuição das variáveis, e os dados apresentam-se em freqüências. RESULTADOS: No período, foram atendidas 28.257 ligações, sendo 7.956 incluídas no estudo. No total, foi encontrada maior prevalência de mulheres, estudantes, solteiros, maiores de 35 anos, com ensino fundamental incompleto e renda familiar menor que cinco salários mínimos procurando o teleatendimento. Dentre os usuários de drogas, predominaram homens, de 18 a 25 anos. As drogas mais utilizadas foram tabaco, maconha, álcool e cocaína. O uso de tabaco foi semelhante para ambos os sexos. Indivíduos do sexo masculino usaram mais drogas ilícitas. A maioria dos usuários era dependente, sendo que os homens apresentaram maiores índices de dependência para tabaco e solventes. CONCLUSÕES: Esses resultados traçam o perfil do usuário que procura auxílio telefônico para a questão de drogas, e revelam a importância desses serviços à população, auxiliando no direcionamento de ações preventivas.

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Substance Use Disorders: Sex Differences and Psychiatric Comorbidities

Abstract: Sex differences in the clinical presentation of substance-dependent individuals with psychiatric comorbidity present specific treatment challenges and opportunities.

Cited by 196 publications

References 66 publications

Prevalence of Co-Occurring Substance Use and other Mental Disorders in the Canadian Population

Prevalence of Co-Occurring Substance Use and other Mental Disorders in the Canadian Population

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys

Perfil dos usuários do serviço de teleatendimento sobre drogas de abuso VIVAVOZ

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Substance Use Disorders: Sex Differences and Psychiatric Comorbidities

Abstract: Sex differences in the clinical presentation of substance-dependent individuals with psychiatric comorbidity present specific treatment challenges and opportunities.

Cited by 196 publications

References 66 publications

Prevalence of Co-Occurring Substance Use and other Mental Disorders in the Canadian Population

Prevalence of Co-Occurring Substance Use and other Mental Disorders in the Canadian Population

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D3 Receptor Activation in Male and Female Monkeys

Perfil dos usuários do serviço de teleatendimento sobre drogas de abuso VIVAVOZ

Contact Info

Product

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Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys