Substance Use Risk Behaviors and Decision-Making Skills Among Cancer-Surviving Adolescents

Hollen, Patricia J.; Hobbie, Wendy L.; Donnangelo, Sarah F.; Shannon, Susan; Erickson, Jeanne M.

doi:10.1177/1043454207304910

Cited by 37 publications

(42 citation statements)

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“…After taking into account demographic, social, and economic differences between the BCCSS and the general population, survivors were less likely to be a In adolescent survivors of childhood cancer, it has been reported that, compared with peers or population data, they are either less likely to be a current alcohol drinker (17,18) or binge drinker (17), or no different to comparators for being a current drinker (18,19). Current drinkers among survivors of non-Hodgkin's lymphoma, Hodgkin's lymphoma, Wilms' tumor, bone sarcoma, and soft tissue sarcoma were similar to the general population in terms of exceeding weekly recommendations or harmful limits, whereas other survivors were less likely than the general population to indulge in such practices.…”

Section: Discussionmentioning

confidence: 99%

Extent of Alcohol Consumption among Adult Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study

Frobisher

Lancashire²,

Reulen³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: This study aimed to identify subgroups of childhood cancer survivors at highest risk of consuming alcohol, consuming above recommended weekly levels, and consuming potentially harmful amounts and compare survivor risks with those expected from the general population.Methods: Using the British Childhood Cancer Survivor Study, a population-based cohort of 17,981 individuals diagnosed with childhood cancer and surviving ≥5 years, 14,836 were eligible for a questionnaire that ascertained drinking behavior, as previously ascertained in the 2002 General Household Survey throughout Britain.Results: Of 10,389 survivors who responded, 77.2% were alcohol drinkers, 23.8% consumed over weekly recommendations, and 3.9% consumed potentially harmful amounts. Survivors were less likely than the general population to be a current drinker {odds ratio [OR; 99% confidence interval (CI)]: 0.52 (0.46-0.60)}, consume over weekly recommended levels [OR (99% CI): 0.65 (0.58-0.73)], and consume harmful amounts [OR (99% CI): 0.40 (0.32-0.49)]. Survivors of a central nervous system neoplasm or leukemia, particularly those treated with brain irradiation, were the least likely to have adverse drinking behaviors when compared with the general population. However, survivors of Hodgkin's lymphoma, non-Hodgkin's lymphoma, Wilms' tumor, bone sarcoma, and soft tissue sarcoma had adverse drinking behaviors at levels expected from the general population.Conclusion: Overall adverse drinking behaviors were less frequent in survivors than expected from the general population, but subgroups with adverse drinking behaviors were identified, and it is these subgroups who are most in need of intervention.Impact: UK clinical follow-up guidelines for childhood cancer survivors need strengthening in relation to alcohol consumption. Cancer Epidemiol Biomarkers Prev; 19(5); 1174-84. ©2010 AACR. IntroductionIn the United Kingdom, alcohol consumption is part of modern culture (1), and at moderate levels of intake, it has been associated with a beneficial effect on cardiovascular risk in the general population (2). However, it has been shown to increase the risk of cancer of the mouth, pharynx and larynx, esophagus, colorectum, liver, and breast (3). Childhood cancer survivors are likely to be particularly susceptible to the harmful effects of alcohol, as they are at a 3-to 6-fold increased risk of a second primary neoplasm resulting largely from their exposure to anticancer therapy (4). Alcohol consumption could exacerbate other late consequences of childhood cancer treatment, including increased risks of cardiovascular dysfunction, osteoporosis, and liver damage (5, 6).Alcohol consumption has been investigated among childhood cancer survivors (7), but comparisons between studies are difficult because of many confounding influences. No previous large-scale investigation of the drinking behaviors among childhood cancer survivors in Britain has been undertaken. Therefore, we aimed to determine the prevalence of those currently drinking alcohol, ...

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Section: Discussionmentioning

confidence: 99%

Extent of Alcohol Consumption among Adult Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study

Frobisher

Lancashire²,

Reulen³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…[4][5][6][7][8] Several investigations have reported smoking rates for CCS to be lower than the rates reported for siblings and sexand age-matched controls. 7,[9][10][11][12] Others have found no differences, 1,13,14 while yet others have reported increased rates among CCS. [15][16][17] Despite the variation in findings, the percentage of CCS who reported being daily (current) smokers is substantial, with previous investigations reporting daily smoking rates ranging from 17% to 25%.…”

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confidence: 93%

“…[2][3][4][5][6] In turn, life-style factors are known to influence survivors' risk of disease and thus may further increase the risk of adverse late effects among these individuals. 3,7 Specifically, smoking potentiates the organ damage resulting from exposure to radiation and chemotherapy during treatment, and excessive alcohol consumption may pose an increased risk for breast cancer and cancers of the gastrointestinal tract. [4][5][6][7][8] Several investigations have reported smoking rates for CCS to be lower than the rates reported for siblings and sexand age-matched controls.…”

mentioning

confidence: 99%

“…3,7 Specifically, smoking potentiates the organ damage resulting from exposure to radiation and chemotherapy during treatment, and excessive alcohol consumption may pose an increased risk for breast cancer and cancers of the gastrointestinal tract. [4][5][6][7][8] Several investigations have reported smoking rates for CCS to be lower than the rates reported for siblings and sexand age-matched controls. 7,[9][10][11][12] Others have found no differences, 1,13,14 while yet others have reported increased rates among CCS.…”

mentioning

confidence: 99%

“…[15][16][17] Despite the variation in findings, the percentage of CCS who reported being daily (current) smokers is substantial, with previous investigations reporting daily smoking rates ranging from 17% to 25%. 7,12,[18][19][20] As with cigarette smoking research, reported alcohol consumption rates among CCS compared to comparison control groups vary. The findings of several studies suggest that CCS have lower rates of alcohol consumption compared with siblings or age-and sex-matched controls.…”

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confidence: 99%

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Engagement in High-Risk Behaviors Among Young Adult Survivors of Childhood Cancer Compared to Healthy Same-Age Peers Surveyed in the National Longitudinal Study of Adolescent Health

Cantrell

Posner

2016

Journal of Adolescent and Young Adult Oncology

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Purpose: This secondary data analysis compared smoking rates, alcohol consumption, and binge drinking, and examined risk factors for engaging in these behaviors among 90 young adult-aged childhood cancer survivors (CSS) with 15,490 young adults in the general population. Methods: The sample was drawn from the National Longitudinal Study of Adolescent Health. The sampling distribution of these healthy matched young adults was estimated through the use of bootstrapping, which involved randomly repeated for 10,000 samples of healthy controls. Results: The findings of repeated sampling analysis revealed that CCS were more likely to smoke daily (34.5% vs. 20.6 healthy matched controls; p = 0.03). The proportion of respondents who had any signs of alcohol abuse symptoms was 72.2% of CCS compared with 81.1% of matched controls ( p = 0.16), while CCS with severe alcohol abuse was 51.1% compared with 59.1% of matched controls ( p = 0.28). Whether they engaged in binge drinking in the past 12 months was 43.3% for CCS and 46.4% for healthy respondents. Logistic regression analyses were performed to examine predictors of smoking, alcohol use, and binge drinking among CCS. Smoking was very strongly associated with optimism. An optimism score of one unit higher was associated with a 39% reduction in odds of smoking (odd ratio [OR] = 0.61, p < 0.0001). Black CSS were less likely to smoke (OR = 0.15, p < 0.05). CCS in good health were more likely to binge drink (OR = 3.67, p < 0.05). Conclusions: Data generated from this secondary data analyses add to the evidence base about the engagement in high risk behaviors among young adult-aged CCS. These findings further emphasize the need for widespread, available effective theory-based screening guidelines and interventions.

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Burden of Childhood Cancer and the Social and Economic Challenges in Adulthood

Hernádfői,

Koch,

Kói

et al. 2024

JAMA Pediatr

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ImportanceSignificant advancements in pediatric oncology have led to a continuously growing population of survivors. Although extensive research is being conducted on the short-, medium-, and long-term somatic effects, reports on psychosocial reintegration are often conflicting; therefore, there is an urgent need to synthesize the evidence to obtain the clearest understanding and the most comprehensive answer.ObjectiveTo provide a comprehensive review and analysis of the socioeconomic attainment of childhood cancer survivors (CCSs) compared with their unaffected peers.Data SourcesA systematic review and meta-analysis was conducted using data obtained from a comprehensive search of MEDLINE (via PubMed), Embase, and CENTRAL (Cochrane Central Register of Controlled Trials) databases on October 23, 2021; the search was updated until July 31, 2023.Study SelectionEligible articles reported on educational attainment, employment, family formation, quality of life (QoL), or health-risk behavior-related outcomes of CCSs, and compared them with their unaffected peers. Study selection was performed in duplicate by 4 blinded independent coauthors.Data Extraction and SynthesisData extraction was performed in duplicate by 4 independent authors following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Outcome measures were odds ratios (ORs) and mean differences with 95% CIs; data were pooled using a random-effects model.ResultsThe search identified 43 913 articles, 280 of which were eligible for analysis, reporting data on a total of 389 502 survivors. CCSs were less likely to complete higher levels of education (OR, 0.69; 95% CI, 0.40-1.18), had higher odds of health-related unemployment (OR, 2.94; 95% CI, 1.90-4.57), and showed lower rates of marriage (OR, 0.72; 95% CI, 0.63-0.84) and parenthood (OR, 0.60; 95% CI, 0.49-0.74) compared with population-based controls.Conclusion and RelevanceStudy findings suggest that CCSs face several socioeconomic difficulties; as a result, the next goal of pediatric oncology should be to minimize adverse effects, as well as to provide lifelong survivorship support aimed at maximizing social reintegration.

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Substance Use Risk Behaviors and Decision-Making Skills Among Cancer-Surviving Adolescents

Cited by 37 publications

References 27 publications

Extent of Alcohol Consumption among Adult Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study

Extent of Alcohol Consumption among Adult Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study

Engagement in High-Risk Behaviors Among Young Adult Survivors of Childhood Cancer Compared to Healthy Same-Age Peers Surveyed in the National Longitudinal Study of Adolescent Health

Burden of Childhood Cancer and the Social and Economic Challenges in Adulthood

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